[go: up one dir, main page]

WO2008065444A3 - Substituted quinazolines - Google Patents

Substituted quinazolines Download PDF

Info

Publication number
WO2008065444A3
WO2008065444A3 PCT/GB2007/050697 GB2007050697W WO2008065444A3 WO 2008065444 A3 WO2008065444 A3 WO 2008065444A3 GB 2007050697 W GB2007050697 W GB 2007050697W WO 2008065444 A3 WO2008065444 A3 WO 2008065444A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
present
platelet lowering
substituted quinazolines
discovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/050697
Other languages
French (fr)
Other versions
WO2008065444B1 (en
WO2008065444A2 (en
Inventor
Richard Franklin
Bernard Golding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire LLC
Original Assignee
Shire LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0719570-2A priority Critical patent/BRPI0719570A2/en
Priority to CA002670123A priority patent/CA2670123A1/en
Priority to EA200900740A priority patent/EA018259B1/en
Priority to JP2009538792A priority patent/JP2010511030A/en
Priority to EP07824909A priority patent/EP2099802A2/en
Priority to AU2007327047A priority patent/AU2007327047B2/en
Priority to CN2007800442429A priority patent/CN101558071B/en
Priority to MX2009005579A priority patent/MX2009005579A/en
Application filed by Shire LLC filed Critical Shire LLC
Publication of WO2008065444A2 publication Critical patent/WO2008065444A2/en
Publication of WO2008065444A3 publication Critical patent/WO2008065444A3/en
Publication of WO2008065444B1 publication Critical patent/WO2008065444B1/en
Priority to IL198809A priority patent/IL198809A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention relates to the discovery of 3-and 5-substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
PCT/GB2007/050697 2006-11-28 2007-11-19 Substituted quinazolines Ceased WO2008065444A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN2007800442429A CN101558071B (en) 2006-11-28 2007-11-19 Substituted quinazolines
EA200900740A EA018259B1 (en) 2006-11-28 2007-11-19 Substituted quinazolines
JP2009538792A JP2010511030A (en) 2006-11-28 2007-11-19 Substituted quinazolines
EP07824909A EP2099802A2 (en) 2006-11-28 2007-11-19 Substituted quinazolines
AU2007327047A AU2007327047B2 (en) 2006-11-28 2007-11-19 Substituted quinazolines
BRPI0719570-2A BRPI0719570A2 (en) 2006-11-28 2007-11-19 REPLACED QUINAZOLINS
CA002670123A CA2670123A1 (en) 2006-11-28 2007-11-19 Substituted quinazolines
MX2009005579A MX2009005579A (en) 2006-11-28 2007-11-19 Substituted quinazolines.
IL198809A IL198809A0 (en) 2006-11-28 2009-05-19 Substituted quinazolines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0623750.7 2006-11-28
GBGB0623750.7A GB0623750D0 (en) 2006-11-28 2006-11-28 Substituted quinazolines

Publications (3)

Publication Number Publication Date
WO2008065444A2 WO2008065444A2 (en) 2008-06-05
WO2008065444A3 true WO2008065444A3 (en) 2008-07-31
WO2008065444B1 WO2008065444B1 (en) 2008-10-09

Family

ID=37671460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/050697 Ceased WO2008065444A2 (en) 2006-11-28 2007-11-19 Substituted quinazolines

Country Status (14)

Country Link
EP (1) EP2099802A2 (en)
JP (1) JP2010511030A (en)
KR (1) KR20090094268A (en)
CN (1) CN101558071B (en)
AR (1) AR064002A1 (en)
AU (1) AU2007327047B2 (en)
BR (1) BRPI0719570A2 (en)
CA (1) CA2670123A1 (en)
EA (1) EA018259B1 (en)
GB (1) GB0623750D0 (en)
IL (1) IL198809A0 (en)
MX (1) MX2009005579A (en)
TW (1) TW200838537A (en)
WO (1) WO2008065444A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
GB0822970D0 (en) * 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201017783D0 (en) 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021338A1 (en) * 1979-06-20 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Quinazoline derivatives and pharmaceutical preparations
US4256748A (en) * 1977-07-25 1981-03-17 Hoffmann-La Roche Inc. Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
WO2006017822A2 (en) * 2004-08-04 2006-02-16 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803535B (en) * 1979-06-20 1981-06-24 Hoffmann La Roche Novel quinazoline derivatives and pharmaceutical preparations
DK1589973T4 (en) * 2003-01-23 2013-04-08 Shire Biopharmaceuticals Holdings Ireland Ltd Formulation and methods for the treatment of thrombocythaemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256748A (en) * 1977-07-25 1981-03-17 Hoffmann-La Roche Inc. Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
EP0021338A1 (en) * 1979-06-20 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Quinazoline derivatives and pharmaceutical preparations
WO2006017822A2 (en) * 2004-08-04 2006-02-16 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIENZLE F ET AL: "1,5-DIHYDROIMIDAZOQUINAZOLINONES AS BLOOD PLATELET AGGREGATION INHIBITORS", CHIMIE THERAPEUTIQUE, EDITIONS DIMEO, ARCUEIL, FR, vol. 17, no. 6, 1 January 1982 (1982-01-01), pages 547 - 556, XP009059097, ISSN: 0009-4374 *
VENUTI M C ET AL: "INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASE. 2. STRUCTURAL VARIATIONS OF N-CYCLOHEXYL-N-METHYL-4- not (1,2,3,5-TETRAHYDRO-2-OXOIMIDAZO not 2,1-B 3/4 QUINAZOLIN-7-YL)-OXY 3/4 BUTYRAMIDE (RS-82856)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 30, no. 2, 1 January 1987 (1987-01-01), pages 303 - 318, XP000941985, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
IL198809A0 (en) 2010-02-17
CA2670123A1 (en) 2008-06-05
TW200838537A (en) 2008-10-01
WO2008065444B1 (en) 2008-10-09
WO2008065444A2 (en) 2008-06-05
AU2007327047A1 (en) 2008-06-05
CN101558071B (en) 2013-04-24
JP2010511030A (en) 2010-04-08
AU2007327047B2 (en) 2012-08-30
CN101558071A (en) 2009-10-14
EP2099802A2 (en) 2009-09-16
EA200900740A1 (en) 2010-02-26
KR20090094268A (en) 2009-09-04
AR064002A1 (en) 2009-03-04
GB0623750D0 (en) 2007-01-10
EA018259B1 (en) 2013-06-28
BRPI0719570A2 (en) 2013-12-10
MX2009005579A (en) 2009-08-12

Similar Documents

Publication Publication Date Title
WO2010141796A3 (en) PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES
WO2009145456A3 (en) Heterocyclic derivatives
WO2008033562A3 (en) Kinase inhibitor compounds
WO2008044217A3 (en) 2-aminocarbonyl-pyridine derivatives
WO2005004818A3 (en) Heterocyclic compounds and their use as anticancer agents
WO2004022537A3 (en) Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands
WO2006044775A3 (en) Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity
WO2009091550A3 (en) Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
WO2007044085A3 (en) Heteroaryl compounds and their uses as therapeutic agents
WO2007093880A3 (en) Novel pyrone-indole derivatives and process for their preparation
WO2007068894A3 (en) Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease
WO2008050301A3 (en) 2- phenyl- 6-aminocarbonyl- pyrimidine derivatives and their use as p2y12 receptor antagonists
WO2008049855A3 (en) 7-azaindole derivatives as c-met kinase inhibitors
WO2006114774A3 (en) Pyrimidine derivatives and their use as p2y12 receptor antagonists
WO2007098964A3 (en) Pyrrazole derivatives as sigma receptors antagonists
WO2009003719A3 (en) Indane-amine derivatives, their preparation and use as medicaments
WO2008008700A3 (en) Substituted cyclopentane derivatives as therapeutic agents
WO2008065444A3 (en) Substituted quinazolines
WO2010121675A3 (en) Thiazolyl-benzimidazoles
MY150745A (en) Isoserine derivatives for use as coagulation factor ixa inhibitors
TW200745136A (en) 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
WO2009138796A3 (en) Imidazo [2,1-b] quinazolin-2-one derivatives and their use as platelet anti-aggregative agents
WO2007009721A3 (en) Indoline-substituted pyrazoline derivatives, their preparation and use as medicaments
WO2007098967A3 (en) Imidazole compounds having pharmaceutical activity towards the sigma receptor
MY149620A (en) Amino quinazolines derivatives with blood platelet reducing properties

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780044242.9

Country of ref document: CN

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2007327047

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 198809

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2670123

Country of ref document: CA

Ref document number: 3313/DELNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 12009501021

Country of ref document: PH

WWE Wipo information: entry into national phase

Ref document number: 2009050781

Country of ref document: EG

WWE Wipo information: entry into national phase

Ref document number: MX/A/2009/005579

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2009538792

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1020097011682

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2007327047

Country of ref document: AU

Date of ref document: 20071119

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2007824909

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200900740

Country of ref document: EA

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07824909

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: PI0719570

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090528