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WO2008064310A3 - Mixed opioid receptor active compounds - Google Patents

Mixed opioid receptor active compounds Download PDF

Info

Publication number
WO2008064310A3
WO2008064310A3 PCT/US2007/085384 US2007085384W WO2008064310A3 WO 2008064310 A3 WO2008064310 A3 WO 2008064310A3 US 2007085384 W US2007085384 W US 2007085384W WO 2008064310 A3 WO2008064310 A3 WO 2008064310A3
Authority
WO
WIPO (PCT)
Prior art keywords
opioid receptor
compounds
active compounds
receptor active
mixed opioid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/085384
Other languages
French (fr)
Other versions
WO2008064310A2 (en
Inventor
William J Welsh
Sonia Arora
Kaipeen Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Rutgers Health
Original Assignee
University of Medicine and Dentistry of New Jersey
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Medicine and Dentistry of New Jersey, Rutgers State University of New Jersey filed Critical University of Medicine and Dentistry of New Jersey
Publication of WO2008064310A2 publication Critical patent/WO2008064310A2/en
Publication of WO2008064310A3 publication Critical patent/WO2008064310A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pyrazoles, imidazoles, triazoles, other 5-membered heteroaromatic ring compounds substituted with two phenyl groups, and like compounds, may be included in pharmaceutical compositions to treat a condition mediated by an opioid receptor in a patient. The compounds possess a high binding affinity and high selectivity for delta, kappa and mu opioid receptors. Such mixed opioid receptor active compounds are useful for treating pain, inflammation, arthritis, central nervous system disorders, and other diseases.
PCT/US2007/085384 2006-11-22 2007-11-21 Mixed opioid receptor active compounds Ceased WO2008064310A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86709506P 2006-11-22 2006-11-22
US60/867,095 2006-11-22

Publications (2)

Publication Number Publication Date
WO2008064310A2 WO2008064310A2 (en) 2008-05-29
WO2008064310A3 true WO2008064310A3 (en) 2008-08-21

Family

ID=39430590

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/085384 Ceased WO2008064310A2 (en) 2006-11-22 2007-11-21 Mixed opioid receptor active compounds

Country Status (1)

Country Link
WO (1) WO2008064310A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US8829041B2 (en) 2006-06-23 2014-09-09 Abbvie Inc. Cyclopropyl amine derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
AR094929A1 (en) 2013-02-28 2015-09-09 Bristol Myers Squibb Co DERIVATIVES OF PHENYLPIRAZOL AS POWERFUL INHIBITORS OF ROCK1 AND ROCK2
CN105102448B (en) 2013-02-28 2018-03-06 百时美施贵宝公司 Phenylpyrazole derivatives as ROCK1 and ROCK2 inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625224A (en) * 1969-04-30 1971-12-07 Reynolds Tobacco Co R Tobacco product
US7045520B2 (en) * 2002-02-07 2006-05-16 The Curators Of The University Of Missouri Opioid receptor active compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625224A (en) * 1969-04-30 1971-12-07 Reynolds Tobacco Co R Tobacco product
US7045520B2 (en) * 2002-02-07 2006-05-16 The Curators Of The University Of Missouri Opioid receptor active compounds

Also Published As

Publication number Publication date
WO2008064310A2 (en) 2008-05-29

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