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WO2008062309A3 - Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus - Google Patents

Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus Download PDF

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Publication number
WO2008062309A3
WO2008062309A3 PCT/IB2007/004174 IB2007004174W WO2008062309A3 WO 2008062309 A3 WO2008062309 A3 WO 2008062309A3 IB 2007004174 W IB2007004174 W IB 2007004174W WO 2008062309 A3 WO2008062309 A3 WO 2008062309A3
Authority
WO
WIPO (PCT)
Prior art keywords
coronavirus
molecules
compositions
treating
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/004174
Other languages
French (fr)
Other versions
WO2008062309A2 (en
Inventor
Beatrice Therese Marie Nal-Rogier
Ralf Marius Altmeyer
Francois Kien
Jean Millet
Kim Tat Teoh
Yu Lam Siu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hong Kong HKU
Original Assignee
University of Hong Kong HKU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hong Kong HKU filed Critical University of Hong Kong HKU
Publication of WO2008062309A2 publication Critical patent/WO2008062309A2/en
Publication of WO2008062309A3 publication Critical patent/WO2008062309A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)

Abstract

The present invention relates to the field of coronavirus and more particularly to anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus such as the one responsible for SARS. The present invention also relates to a method for screening new anti- coronavirus molecules.
PCT/IB2007/004174 2006-11-20 2007-11-20 Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus Ceased WO2008062309A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002569080A CA2569080A1 (en) 2006-11-20 2006-11-20 Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus
CA2,569,080 2006-11-20

Publications (2)

Publication Number Publication Date
WO2008062309A2 WO2008062309A2 (en) 2008-05-29
WO2008062309A3 true WO2008062309A3 (en) 2008-12-04

Family

ID=39420417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004174 Ceased WO2008062309A2 (en) 2006-11-20 2007-11-20 Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus

Country Status (2)

Country Link
CA (1) CA2569080A1 (en)
WO (1) WO2008062309A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111675752B (en) * 2020-03-16 2023-07-07 成都奥达生物科技有限公司 A kind of coronavirus membrane fusion inhibitor and its medicinal use
WO2022024108A1 (en) * 2020-07-28 2022-02-03 Rapo Yerape B.H. Ltd. Ezrin peptide (hep-1) for use in the treatment of coronavirus disease
US20230057094A1 (en) 2020-08-29 2023-02-23 Rosa Maria Portillo Rosado Pharmaceutical composition containing a surfactant and natural plant extracts for preventing and treating coronavirus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047150A2 (en) * 1998-03-18 1999-09-23 Institut Curie A pharmaceutical composition containing ezrin mutated on tyrosine 353

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047150A2 (en) * 1998-03-18 1999-09-23 Institut Curie A pharmaceutical composition containing ezrin mutated on tyrosine 353

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HO ET AL: "Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 69, no. 2, 1 February 2006 (2006-02-01), pages 70 - 76, XP005269148, ISSN: 0166-3542 *
HO ET AL: "Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 74, no. 2, 23 March 2007 (2007-03-23), pages 92 - 101, XP005933984, ISSN: 0166-3542 *
HO T-Y ET AL: "Antigenicity and receptor-binding ability of recombinant SARS coronavirus spike protein", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 313, no. 4, 23 January 2004 (2004-01-23), pages 938 - 947, XP004482920, ISSN: 0006-291X *
STADLER K ET AL: "SARS - BEGINNING TO UNDERSTAND A NEW VIRUS", NATURE REVIEWS. MICROBIOLOGY, NATURE PUBLISHING GROUP, GB, vol. 1, no. 3, 1 December 2003 (2003-12-01), pages 209 - 218, XP009059463, ISSN: 1740-1526 *
YI L ET AL: "Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 78, no. 20, 1 October 2004 (2004-10-01), pages 11334 - 11339, XP002993121, ISSN: 0022-538X *

Also Published As

Publication number Publication date
CA2569080A1 (en) 2008-05-20
WO2008062309A2 (en) 2008-05-29

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