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WO2008060695A8 - Inhibition antivirale de la caséine kinase ii - Google Patents

Inhibition antivirale de la caséine kinase ii Download PDF

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Publication number
WO2008060695A8
WO2008060695A8 PCT/US2007/069472 US2007069472W WO2008060695A8 WO 2008060695 A8 WO2008060695 A8 WO 2008060695A8 US 2007069472 W US2007069472 W US 2007069472W WO 2008060695 A8 WO2008060695 A8 WO 2008060695A8
Authority
WO
WIPO (PCT)
Prior art keywords
virus
inhibit
compounds
disclosed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/069472
Other languages
English (en)
Other versions
WO2008060695A9 (fr
WO2008060695A3 (fr
WO2008060695A2 (fr
Inventor
David Weiner
Mathura Ramanathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority to US12/301,993 priority Critical patent/US20100256217A1/en
Publication of WO2008060695A2 publication Critical patent/WO2008060695A2/fr
Publication of WO2008060695A9 publication Critical patent/WO2008060695A9/fr
Anticipated expiration legal-status Critical
Publication of WO2008060695A3 publication Critical patent/WO2008060695A3/fr
Publication of WO2008060695A8 publication Critical patent/WO2008060695A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un procédé de traitement d'un individu exposé à et/ou infecté par un virus choisi dans le groupe comprenant : le virus du Nil occidental, le virus de l'encéphalite japonaise, le virus Kunjin, le virus de l'encéphalite à tiques et le virus de l'hépatite C. Les procédés comprennent l'administration à de tels individus d'une quantité thérapeutiquement efficace d'un ou plusieurs des composés qui inhibent l'activité de la CK2, d'un ou plusieurs des composés qui inhibent l'expression de la CK2 ou une combinaison de ceux-ci. La présente invention décrit également des compositions pharmaceutiques comprenant une quantité thérapeutiquement efficace d'un ou plusieurs des composés qui inhibent l'activité de la CK2, d'un ou plusieurs des composés qui inhibent l'expression de la CK2, ou d'une combinaison de ceux-ci. La présente invention décrit des procédés d'inhibition de la réplication virale d'un virus choisi dans le groupe comprenant : le virus du Nil occidental, le virus de l'encéphalite japonaise, le virus Kunjin, le virus de l'encéphalite à tiques et le virus de l'hépatite C, utilisant un ou plusieurs des composés qui inhibent l'activité de la CK2, un ou plusieurs des composés qui inhibent l'expression de la CK2 et des combinaisons de ceux-ci. La présente invention concerne des procédés d'identification de composés utiles pour traiter une infection par un virus choisi dans le groupe comprenant : le virus du Nil occidental, le virus de l'encéphalite japonaise, le virus Kunjin, le virus de l'encéphalite à tiques et le virus de l'hépatite C, et des procédés d'identification d'inhibiteurs de la CK2.
PCT/US2007/069472 2006-05-22 2007-05-22 Inhibition antivirale de la caséine kinase ii Ceased WO2008060695A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/301,993 US20100256217A1 (en) 2006-05-22 2007-05-22 Antiviral inhibition of casein kinase ii

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80282806P 2006-05-22 2006-05-22
US60/802,828 2006-05-22
US87976607P 2007-01-09 2007-01-09
US60/879,766 2007-01-09

Publications (4)

Publication Number Publication Date
WO2008060695A2 WO2008060695A2 (fr) 2008-05-22
WO2008060695A9 WO2008060695A9 (fr) 2008-07-03
WO2008060695A3 WO2008060695A3 (fr) 2008-12-24
WO2008060695A8 true WO2008060695A8 (fr) 2009-07-23

Family

ID=39402322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069472 Ceased WO2008060695A2 (fr) 2006-05-22 2007-05-22 Inhibition antivirale de la caséine kinase ii

Country Status (2)

Country Link
US (1) US20100256217A1 (fr)
WO (1) WO2008060695A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732293B (zh) * 2008-11-21 2012-05-23 上海医药工业研究院 9,10-蒽醌类化合物的应用
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
DE112012003510T5 (de) 2011-10-21 2015-03-19 Abbvie Inc. Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
BR112018002550A2 (pt) 2015-08-10 2018-09-18 Dana Farber Cancer Inst Inc mecanismo de resistência a inibidores do bromodomínio de bet
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
CN111072723B (zh) * 2019-12-27 2022-10-11 湖北工业大学 单碘代苯甲酸通过共价键修饰的安德森多酸有机衍生物及其在抗adv7病毒中的应用
US20220080020A1 (en) * 2020-08-22 2022-03-17 Luc Montagnier Compositions and methods for reducing the transmissivity of illnesses using an oral delivery system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2227688C (fr) * 1998-01-16 2007-07-31 James W. Critchfield Methode et compositions pour inhiber la reproduction virale
US20040121968A1 (en) * 2002-12-23 2004-06-24 Alexander Ljubimov Antiangiogenesis by inhibiting protein kinase CK2 activity
JP2007521331A (ja) * 2003-11-19 2007-08-02 シグナル ファーマシューティカルズ，エルエルシー 複数キナーゼの標的化による疾患及び障害の治療方法

Also Published As

Publication number Publication date
WO2008060695A9 (fr) 2008-07-03
WO2008060695A3 (fr) 2008-12-24
US20100256217A1 (en) 2010-10-07
WO2008060695A2 (fr) 2008-05-22

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