[go: up one dir, main page]

WO2008060568A3 - Amide-substituted aryl piperidines - Google Patents

Amide-substituted aryl piperidines Download PDF

Info

Publication number
WO2008060568A3
WO2008060568A3 PCT/US2007/023936 US2007023936W WO2008060568A3 WO 2008060568 A3 WO2008060568 A3 WO 2008060568A3 US 2007023936 W US2007023936 W US 2007023936W WO 2008060568 A3 WO2008060568 A3 WO 2008060568A3
Authority
WO
WIPO (PCT)
Prior art keywords
amide
substituted aryl
cgrp
compounds
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/023936
Other languages
French (fr)
Other versions
WO2008060568A2 (en
Inventor
Rajagopal Bakthavatchalam
Scott M Capitosti
Alan J Hutchison
Guiying Li
John M Peterson
Charles S Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of WO2008060568A2 publication Critical patent/WO2008060568A2/en
Publication of WO2008060568A3 publication Critical patent/WO2008060568A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Amide-substituted aryl piperidines derivatives of the following Formulas are provided:(Formulas), in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache, such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.
PCT/US2007/023936 2006-11-15 2007-11-14 Amide-substituted aryl piperidines Ceased WO2008060568A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86586206P 2006-11-15 2006-11-15
US60/865,862 2006-11-15

Publications (2)

Publication Number Publication Date
WO2008060568A2 WO2008060568A2 (en) 2008-05-22
WO2008060568A3 true WO2008060568A3 (en) 2008-08-21

Family

ID=39402246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023936 Ceased WO2008060568A2 (en) 2006-11-15 2007-11-14 Amide-substituted aryl piperidines

Country Status (1)

Country Link
WO (1) WO2008060568A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039038A1 (en) 2006-08-19 2008-02-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg New manufacturing process
AU2009309019B2 (en) * 2008-10-31 2014-11-13 Merck Sharp & Dohme Llc P2X3, receptor antagonists for treatment of pain
WO2010070022A1 (en) * 2008-12-19 2010-06-24 Boehringer Ingelheim International Gmbh Novel compounds
CN120025328A (en) * 2019-11-06 2025-05-23 拜耳公司 Adrenergic receptor ADRAC2 antagonist

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US20050096345A1 (en) * 2003-07-10 2005-05-05 Aventis Pharma S.A. Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use
US20050256302A1 (en) * 2002-06-04 2005-11-17 Japan Science And Technology Agency Novel peptides having camp producing activity
US20060229301A1 (en) * 2003-04-18 2006-10-12 Rena Nishizawa Spiro-piperidine compounds and medicinal use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812226B2 (en) * 1999-12-17 2004-11-02 Astrazeneca Ab P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
US20050256302A1 (en) * 2002-06-04 2005-11-17 Japan Science And Technology Agency Novel peptides having camp producing activity
US20060229301A1 (en) * 2003-04-18 2006-10-12 Rena Nishizawa Spiro-piperidine compounds and medicinal use thereof
US20050096345A1 (en) * 2003-07-10 2005-05-05 Aventis Pharma S.A. Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use

Also Published As

Publication number Publication date
WO2008060568A2 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
TW200716594A (en) Substituted heteroaryl CB1 antagonists
WO2007140383A3 (en) Spirocyclic sulfonamides and related compounds
MY148461A (en) Heteroaryl amide analogues as p2x7 antagonists
WO2008066789A3 (en) Heteroaryl amide derivatives
WO2006078992A3 (en) Heteroaryl substituted piperazinyl-pyridine analogues
WO2009012482A3 (en) 5-membered heterocyclic amides and related compounds
WO2007101007A3 (en) Aryl sulfonyl heterocycles
WO2006049941A3 (en) Diaryl ureas as cb1 antagonists
WO2007146761A3 (en) Diaryl pyrimidinones and related compounds
WO2005007648A3 (en) Biaryl piperazinyl-pyridine analogues
WO2008016811A3 (en) Aminopiperidines and realted compounds
WO2008024433A3 (en) Haloalkyl-substituted pyrimidinone derivatives
WO2005007652A3 (en) Substituted quinolin-4-ylamine analogues
WO2008033739A3 (en) Benzimidazole carboxamide derivatives
WO2008024438A3 (en) 2-phenoxy pyrimidinone analogues
WO2006026135A3 (en) Substituted biaryl piperazinyl-pyridine analogues
WO2008066664A3 (en) Cis-cyclohexyl substituted pyrimidinone derivatives
WO2006076646A3 (en) Heteroaryl substituted quinolin-4-ylamine analogues
WO2006081388A3 (en) Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues
WO2008070014A3 (en) Biaryl ketone-substituted piperidines
WO2006042289A3 (en) Substituted biaryl quinolin-4-ylamine analogues
WO2007133820A3 (en) Diaryl triazolones as cb1 antagonists
WO2008060568A3 (en) Amide-substituted aryl piperidines
WO2005084401A3 (en) Aryl substituted purine analogues
WO2005084368A3 (en) Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07840050

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07840050

Country of ref document: EP

Kind code of ref document: A2