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WO2008059728A1 - Dispositif de type capsule pour administrer un médicament - Google Patents

Dispositif de type capsule pour administrer un médicament Download PDF

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Publication number
WO2008059728A1
WO2008059728A1 PCT/JP2007/071513 JP2007071513W WO2008059728A1 WO 2008059728 A1 WO2008059728 A1 WO 2008059728A1 JP 2007071513 W JP2007071513 W JP 2007071513W WO 2008059728 A1 WO2008059728 A1 WO 2008059728A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
dosing
opening
space
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/071513
Other languages
English (en)
Japanese (ja)
Inventor
Mitsuru Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Electric Works Co Ltd
Original Assignee
Panasonic Electric Works Co Ltd
Matsushita Electric Works Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2006312029A external-priority patent/JP2008125641A/ja
Priority claimed from JP2006312030A external-priority patent/JP2008125642A/ja
Application filed by Panasonic Electric Works Co Ltd, Matsushita Electric Works Ltd filed Critical Panasonic Electric Works Co Ltd
Publication of WO2008059728A1 publication Critical patent/WO2008059728A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Definitions

  • the present invention relates generally to a dosing device, and more particularly to a capsule-type dosing device.
  • Such a capsule-type dispensing device has already been proposed.
  • Japanese Patent Application Publication No. 2005-185567 discloses a medical capsule device.
  • the main unit is an observation means for observing the inside of the digestive tract, a communication means for transmitting / receiving a signal to / from an external device, and a drug release for receiving a signal from the communication means to control a drug release operation.
  • Control means are provided.
  • the medicine unit is provided with an injection nozzle for containing the medicine and injecting the medicine, and an opening / closing means for opening or closing the injection nozzle.
  • the opening and closing means is made of a soluble membrane that dissolves in the extinguishing tube.
  • the opening / closing means that is, the soluble film
  • the ejection nozzle is eventually opened. Then, while watching the image displayed on the monitor device, the operator waits until the device reaches a desired part. When the device reaches a desired site, the operator transmits a control signal to the main unit. The device receives the control signal and injects the drug into the digestive tract through the injection nozzle.
  • An object of the present invention is to reliably administer a drug to a desired site in the digestive tract.
  • the capsule-type dosing device of the present invention includes a capsule to be administered into the digestive tract, a storage space having a medication opening and formed on one end side of the capsule, and a medicine stored in the storage space Agents and plugs that plug the dosing opening.
  • the apparatus further comprises a movable wall and a drive system.
  • the movable wall is movably placed in the storage space and is formed so as to partition the storage space into a first space and a second space.
  • the first space includes a medication opening and is configured to store a medication.
  • the drive system is configured to remove the stopper from the dosing opening and move the movable wall toward the dosing opening to dispense the drug into the gastrointestinal tract in accordance with a dosing command.
  • the drug can be reliably administered to a desired site in the digestive tract.
  • the movable wall is made of a permanent magnet.
  • the drive system includes a pair of spiral coils and an excitation circuit.
  • Each of the spiral coils is formed on both walls of the wall surrounding the storage space facing both sides of the movable wall.
  • the excitation circuit is configured to supply power to each of the spiral coil so as to move the movable wall toward the medication opening in accordance with the medication command.
  • the movable wall can be moved toward the dosing opening by each magnetic field of the coil, so that the drug can be administered into the digestive tract after the stopper is removed from the dosing opening.
  • the stopper plugs the dosing opening by a loose fit.
  • the drive system is configured to dispense the drug into the extinguishing tube by moving the movable wall toward the dosing opening and removing the stopper from the dosing opening.
  • the movable wall moves toward the medication opening and the pressure in the first space is increased, so that the stopper is pushed out of the medication opening.
  • the medication opening is opened, and the drug in the first space is administered into the digestive tract through the medication opening. Accordingly, since the stopper is removed before the device reaches the desired site, it can be prevented, so that it is possible to prevent the medicine from leaking out before reaching the desired site.
  • the stopper is removed from the dosing opening according to the dosing instruction, the drug can be smoothly administered into the digestive tract.
  • the plug is made from a material that is melted at a melting point that is higher than the temperature in the digestive tract.
  • the drive system is configured to release the plug opening force by melting the plug with the Joule heat of the spiral opening coil on the drug opening side, and subsequently dispense the drug into the gastrointestinal tract.
  • the stopper since the stopper is melted by Joule heat of the coil on the side of the medication opening, the fitting of the stopper to the medication opening can be loosened. Therefore, it is easy to remove the stopper I can do it.
  • the stopper can be strongly fitted into the medication opening, it is possible to prevent the medicine from leaking from the gap between the stopper and the medication opening.
  • the apparatus further comprises a meltable wall made of a meltable film that is melted at a melting point higher than the temperature in the digestive tract, and that partitions the second space into a plurality of working chemical chambers.
  • the drive system includes various types of agonists, a heater, and a heater drive circuit. Each type of agonist is stored in the agonist chamber and mixed to expand the volume.
  • the heater is formed on the wall surrounding the storage space.
  • the heater drive circuit is configured to supply power to the heater in accordance with a medication instruction. In the present invention, when the heater driving circuit supplies power to the heater, the heater heats the meltable wall in the storage space, so that the meltable wall is melted.
  • the stopper closes the medication opening by a loose fit.
  • the drive system is configured to dispense the plug into the gastrointestinal tract while moving the movable wall toward the dosing opening and removing the stopper from the dosing lock.
  • the movable wall moves to the side of the medication opening due to the expansion of various types of agonist, the pressure in the first space is increased and the stopper is pushed out of the medication opening.
  • the medication opening is opened, and the drug in the first space is administered into the digestive tract through the medication opening. Accordingly, since the stopper is removed before the device reaches the desired site, it is possible to prevent the device from leaking before reaching the desired site.
  • the opening force of the plug is also released in accordance with the medication command, the drug can be reliably administered into the digestive tract.
  • the plug may be made from a material that is melted at the melting point! /.
  • the plug when the surface of the stopper is melted by the heater, the gap between the stopper and the medication opening is increased, so that the stopper can be easily removed. As a result, the drug can be reliably administered to a desired site.
  • the device includes a plurality of drugs as the drug.
  • the meltable wall is formed so as to extend through the movable wall to the first space so that the first space is also divided into a plurality of drug chambers.
  • multiple drugs can be stored in multiple drug rooms. Stored.
  • various drugs that are preferably separated in advance can be stored in a plurality of drug chambers, and various drugs can be simultaneously applied to desired sites. Therefore, various drugs can be administered to the desired site.
  • the stopper and the meltable wall are made from beef tallow and are integrated with each other.
  • the stopper when the meltable wall is melted, the stopper is also melted, so that the medication opening can be reliably opened and the drug can be smoothly administered into the digestive tract.
  • the stopper and the meltable wall are made of beef tallow with a melting point of 40-45 ° C, it is difficult to melt at temperatures in the digestive tract.
  • the stopper and meltable wall are melted and absorbed into the subject's body, they are not harmful to health.
  • FIG. 1 is a schematic longitudinal sectional view of a capsule dosing device according to a first embodiment of the present invention.
  • FIG. 2 is a schematic longitudinal sectional view of the dosing device after dosing.
  • FIG. 3 is a schematic view of a coil of the dosing device.
  • FIG. 4 is a flow diagram of manufacturing technology for each coil of the dosing device.
  • FIGS. 5A to 5C are perspective views of the MID in each process of the manufacturing technique.
  • FIG. 6A and FIG. 6B are perspective views of MID in each process of the manufacturing technique.
  • FIG. 7 is a schematic longitudinal sectional view of a capsule dosing device according to a second embodiment of the present invention.
  • FIG. 8 is a schematic longitudinal sectional view of the dosing device after dosing.
  • FIG. 9 is a schematic view of a heater of the dosing device.
  • FIG. 1 shows a capsule-type dispensing device A according to a first embodiment of the present invention.
  • the capsule-type dosing device A includes a capsule 1 made of a heat resistant material such as ceramic or polyetheretherketone (PEEK).
  • the capsule 1 is formed, for example, in an oval shape or a cylinder shape. In the example of FIG. 1, the capsule 1 has a cylindrical shape.
  • the inside of the capsule 1 is left by a fixed wall 2 arranged in the middle part in the axial direction (vertical direction) Divided into right storage spaces 3 and 4.
  • the left accommodation space 3 is provided with a movable wall 5.
  • the movable wall 5 is composed of a planar permanent magnet that is slightly smaller than the cross section of the accommodation space 3, and is placed in the accommodation space 3 so as to move freely in the axial direction.
  • the first space 3a for accommodating the medicine 8 to be administered is formed of a space sandwiched between the left end face of the accommodation space 3 and the movable wall 5.
  • a medication opening 6 for example, a through hole
  • the dosing opening 6 is closed from the outside with a stopper 7 by loose fitting (gap fitting).
  • the plug 7 is made of a material (eg, beef tallow) that is melted at a melting point (eg, 40-45 ° C) higher than the temperature in the digestive tract.
  • the capsule 1 is further formed with a vent hole (not shown) for opening the space between the movable wall 5 and the fixed wall 2 to the outside!
  • a pair of spiral coil coils 9 and 10 are formed on the surface 2a on the side of the accommodation space 4 in the fixed wall 2 and the inner surface la of the left end of the capsule 1 by a MID (molded interconnect device) manufacturing technique, respectively.
  • the manufacturing technique will be described later.
  • FIG. 3 is a schematic diagram of the coil 9 formed on the surface 2 a of the fixed wall 2.
  • the outer end of the spiral coil 9 is a terminal 9a connected to a battery 34 described later.
  • the inner end of the spiral coil 9 is electrically connected to the conductive pattern 11 formed on the back surface through the through hole 2b.
  • the conductive pattern 11 is electrically connected to one end of a conductive line 12 which is a metal plating layer formed on the top of the accommodation space 3 in the axial direction.
  • the other end of the conductive line 12 is electrically connected to a conductive pattern 13 formed on the outer surface of the left end of the capsule 1 via a through hole lb formed on the left end.
  • the conductive pattern 13 is formed on the outer surface of the left end of the capsule 1 from the outer edge to the center side.
  • the end of the conductive pattern 13 on the center side is electrically connected to the inner end of the spiral coil 10 formed on the inner surface la of the left end through a through hole lc formed on the left end. Yes.
  • the outer end of the spiral coil 10 is connected to a conductive line 14 that is a metal plating layer formed on the bottom of the accommodation space 3 in the axial direction.
  • a terminal 15 that is electrically connected to the conductive line 14 is formed on the surface 2 a of the fixed wall 2. That is, the spiral coils 9 and 10 are connected in series between the terminals 15 and 9a.
  • the storage space 4 stores a control circuit 30 for performing a medication operation according to a medication command (trigger input).
  • the control circuit 30 includes an excitation circuit 31, a communication circuit 32, and a camera 35.
  • the excitation circuit 31 has a switch element (not shown) connected between the terminals 9a and 15 via the battery 34, and the switch element so as to turn on / off the power supply to the spiral coils 9 and 10. Configured to control on / off of the.
  • the communication circuit 32 is configured to transmit and receive radio signals via an antenna 33 to or from a remote control system (not shown) arranged outside the subject's body.
  • the camera 35 is configured to take an image outside the capsule 1, that is, an image in the subject's digestive tract.
  • the communication circuit 32 transmits a radio signal including image data taken through the camera 35 to the remote control system at specified time intervals.
  • the communication circuit 32 gives the medication command to the excitation circuit 31.
  • the excitation circuit 31 turns on the switch element and applies a DC (direct current) voltage of the battery 34 to the spiral coils 9 and 10. As a result, each of the spiral coils 9 and 10 generates a magnetic field.
  • the direction of the winding of the spiral coil 9 and the excitation current is set so that the spiral coil 9 generates a magnetic field for repelling the movable wall 5.
  • the direction of winding and excitation current of the spiral 'coil 10 is set so that the spiral' coil 10 generates a magnetic field for attracting the movable wall 5. Accordingly, the movable wall 5 in the storage space 3 is moved from the fixed wall 2 side to the medication opening 6 side by the magnetic field of the spiral coils 9 and 10.
  • the capsule-type dosing device A has the above-described configuration! Next, a dosing method via the capsule-type dosing device A (also referred to as capsule 1) will be described.
  • the movable wall 5 in the accommodation space 3 is arranged on the fixed wall 2 side, and then the first space 3a is filled with a medicine from the medication opening 6. Thereafter, the stopper 7 is fitted into the dosing opening 6 and the opening is closed (see FIG. 1).
  • the capsule 1 moves in the digestive tract of the subject by its peristaltic movement. In the meantime, the capsule 1 transmits images taken through the camera 35 to the remote control system at specified time intervals.
  • the remote control system starts from capsule 1 Are displayed on the monitor of the remote control system. Therefore, the person in charge of medicine (operator) can grasp the current position of the capsule 1.
  • the operator operates the remote control system to send a radio signal including a medication command. Transmit to capsule 1 from the remote control system.
  • the communication circuit 32 When the communication circuit 32 receives the medication command for the capsule 1! /, The medication command is given to the excitation circuit 31.
  • the excitation circuit 31 turns on the switch element and applies the DC voltage of the notch 34 to the spiral coils 9 and 10. Therefore, the spiral 'coil 9 generates a magnetic field for repelling the movable wall 5, while the spiral' coil 10 generates a magnetic field for attracting the movable wall 5.
  • each of the spiral coils 9 and 10 generates a magnetic force for moving the movable wall 5 toward the dosing opening 6 side.
  • the capsule-type medication device A feeds the spiral coils 9 and 10 and moves the movable wall 5 as a result. 7 is pushed out of the dosing opening 6 and the drug 8 is administered into the gastrointestinal tract.
  • the timing of dosing is strictly controlled by reducing variation in dosing timing, the drug can be reliably administered to a desired site.
  • the movable wall 5 is driven by the magnetic field of the spiral coils 9 and 10, the movable wall 5 can be driven with a substantially constant force, and the drug 8 can be released from the dosing opening 6 at a substantially constant flow rate. it can.
  • FIGS. 4, 5A-5C, and 6A and 6B the MID manufacturing technique used to form the coils 9 and 10 will be described.
  • Figure 4 is a schematic flow diagram of MID manufacturing technology. MID is
  • PVD physical vapor deposition
  • a laser processing step of separating the circuit portion and the non-circuit portion with a high energy beam for example, a laser beam
  • FIGS. 5A-5C and 6A and 6B show the surface treatment states of MID (C) in each step of FIG.
  • FIG. 5A corresponds to the molding step (S1), and a desired three-dimensional MID 21 is molded through injection molding of an insulating synthetic resin.
  • the molding material of MID21 is, for example, aromatic polyamide or liquid crystalline polyester in the case of a thermoplastic resin, or epoxy resin or saturated polyester in the case of a thermosetting resin. In the case of ceramic, nitride anolemina is used.
  • the molding method of MID21 may be extrusion molding or transfer molding!
  • FIG. 5B corresponds to the metallization process (S2), and the conductive thin film 22 is formed on the surface of the MID 21 by a PVD method such as sputtering, vacuum deposition or ion plating of a copper target, for example.
  • a PVD method such as sputtering, vacuum deposition or ion plating of a copper target, for example.
  • the material of the conductive thin film 22 may be a single metal such as nickel, gold, aluminum, titanium, molybdenum, chromium, tantasten, tin or lead, or an alloy such as brass or NiCr.
  • FIG. 5C corresponds to the laser processing step (S3).
  • a high energy beam for example, a laser beam (electromagnetic beam) is irradiated on the boundary portion of the circuit portion 23a and the non-circuit portion 23b in the 1S conductive thin film 22, and the conductive thin film at the boundary portion is evaporated and removed.
  • the circuit portion 23a and the non-circuit portion 23b are separated by the removal portion 23c, and a desired circuit pattern is formed.
  • FIG. 6A corresponds to the fitting process step (S4).
  • Each of the circuit parts 23a is supplied with current.
  • the plated layer 24 is formed by covering with a thick film of electrolytic copper plating. Since each non-circuit portion 23b is not supplied with current, the thickness of each non-circuit portion 23b does not change.
  • FIG. 6B corresponds to the etching process (S5).
  • the entire circuit pattern of MID21 is etched, and the non-circuit portion 23b is removed. As a result, the MID on which the circuit pattern is formed is obtained.
  • Spiral coils 9 and 10 can be formed by such manufacturing techniques.
  • FIG. 7 shows a capsule dosing device B according to a second embodiment of the present invention.
  • the capsule-type dosing device B includes a capsule 1 made of a heat resistant material such as ceramic or PEEK.
  • the capsule 1 is formed, for example, in an oval shape or a cylinder shape. In the example of FIG. 7, the capsule 1 has a cylinder shape.
  • the inside of the capsule 1 is partitioned into left and right accommodation spaces 3 and 4 by a fixed wall 2 disposed in an intermediate portion in the axial direction (vertical direction).
  • the left accommodation space 3 is provided with a movable wall 5.
  • the movable wall 5 is placed in the accommodation space 3 so as to move freely in the axial direction, and the accommodation space 3 can be partitioned into a first (left side) space 3a and a second (right side) space 3b.
  • the first space 3a stores a plurality of medicines.
  • the second space 3b stores various agonists whose volume is expanded by being mixed.
  • a medication opening 6 which is a slit for opening the first space 3a to the outside is formed.
  • the movable wall 5 is formed with a through hole 5a which is disposed at a position corresponding to the medication opening 6 and penetrates the movable wall 5 in the thickness direction of the movable wall 5! /.
  • the storage space 3 is provided with a meltable wall 7A therein.
  • the meltable wall 7A is made of a meltable film (eg, beef tallow) that is melted at a melting point (eg, 40-45 ° C) higher than the temperature in the digestive tract!
  • This meltable wall 7A is inserted into the dosing opening 6 and the through hole 5a, partitions the first space 3a into the upper drug chamber 3a_l and the lower drug chamber 3a_2, and operates the second space 3b as the upper drug chamber 3b_l and the lower drug chamber. Partition into chamber 3b_2.
  • a plug 7 is formed at the tip of the meltable wall 7A so as to protrude from the dosing opening 6 and close the dosing opening 6.
  • the plug 7 is formed to have a thickness larger than the remaining part of the meltable wall 7A.
  • the two types of drugs 8a and 8b are separated. And can be stored in the chambers 3a_l and 3a_2, respectively.
  • the agonist chambers 3b_l and 3b_2 are provided, the two types of agonists 19a and 19b whose volumes expand when mixed can be separated and stored in the agonist chambers 3b_l and 3b_2, respectively.
  • the agonists 19a and 19b are preferably harmless substances because they are excreted into the body of the subject.
  • agonist 19a is preferably an acid such as vinegar or lemon juice
  • agonist 19b is preferably sodium bicarbonate or lemonade sweets.
  • the drug chambers 3a-l and 3a-2 and the working drug chambers 3b-l and 3b-2 are formed with through holes (not shown), and the drugs 8a and 8b and the working chemicals are respectively formed through the through holes.
  • 19a and 19b are filled. After they are filled, each through-hole is sealed, particularly but not limited to, liquids can enter and exit.
  • drugs 8a and 8b and agonists 19a and 19b are sealed in drug chambers 3a_l and 3a_2 and agonist chambers 3b_l and 3b_2, respectively (see FIG. 7).
  • FIG. 9 shows a schematic shape of the coil heater 17 formed on the surface 2 a of the fixed wall 2.
  • One end of the coiled heater 17 is a terminal 17a connected to a battery 34, which will be described later, and the other end is a terminal 17b, which is a conductive metal layer formed on the top of the accommodation space 3 in the axial direction. Connected to one end of line 12.
  • a conductive line 14 which is a metal plating layer formed in the axial direction is also formed at the bottom of the accommodation space 3, and a terminal 15 electrically connected to one end of the conductive line 14 is connected to the fixed wall 2. Formed on the surface 2a. Since the other ends of the conductive lines 12 and 14 are electrically connected to both ends of the coil heater 16 formed on the inner surface la of the capsule 1, respectively, the coil heaters 16 and 17 are connected between the terminals 17a and 15. Connected in series.
  • the storage space 4 stores a control circuit 30 for supplying power to the coiled heaters 16 and 17 in accordance with a medication command (trigger input).
  • the control circuit 30 includes a heater drive circuit 36, a communication circuit 32, and a camera 35.
  • the heater driving circuit 36 is a switching circuit having a switching element (not shown) connected between the terminals 17a and 15 via the battery 34, and controls the on / off of the switching element to produce a coiled heater. Power supply to 16 and 17 Configured to control force.
  • the communication circuit 32 is configured to transmit and receive radio signals via an antenna 33 to or from a remote control system (not shown) arranged outside the subject's body.
  • the camera 35 is configured to take an image outside of the capsule 1, that is, an image in the subject's digestive tract.
  • the communication circuit 32 transmits a radio signal including image data taken through the camera 35 to the remote control system at specified time intervals. Further, when receiving a radio signal including a medication command (heating command) from the remote operation system, the communication circuit 32 gives the medication command to the heater drive circuit 36. Upon receiving a medication instruction from the communication circuit 32, the heater drive circuit 36 supplies a predetermined power to the coiled heaters 16 and 17 by switching the DC voltage of the battery 34, thereby The storage space 3 is heated by the coil heaters 16 and 17 to a predetermined temperature higher than the melting point.
  • the capsule dosing device B has the above-described configuration. Next, a description will be given of a dosing method via the capsule-type dosing device B (both capsules 1).
  • the meltable wall 7A is inserted into the injection opening 6 and the through hole 5a, and the first space 3a and the second space 3b are partitioned into the chemical chambers 3a_l and 3a_2 and the working chemical chambers 3b_l and 3b_2.
  • drug chambers 3a_l and 3a_2 and agonist chambers 3b_l and 3b_2 are filled with drugs 8a and 8b and agonists 19a and 19b, respectively.
  • the capsule 1 moves in the subject's digestive tract by its peristaltic movement. In the meantime, the capsule 1 transmits images taken through the camera 35 to the remote control system at specified time intervals.
  • the remote control system displays each image from the capsule 1 on the monitor of the remote control system. Therefore, the person in charge of medicine (operator) can grasp the current position of the capsule 1.
  • the operator operates the remote control system and includes a medication command (heating command).
  • the wireless signal is transmitted to the capsule 1 from the power of the remote control system.
  • the communication circuit 32 receives the medication command in the capsule 1, the medication command is given to the heater drive circuit 36.
  • the heater drive circuit 36 uses a switching element to switch the DC voltage of the battery 34, thereby supplying a predetermined power to the coiled heater 1 Supply to 6 and 17, thereby causing the coil heaters 16 and 17 to heat the storage space 3 to a predetermined temperature.
  • the meltable wall 7A and the plug 7 are not melted! /. This is because the meltable wall 7A and the plug 7 are made of a material having a melting point higher than the temperature in the digestive tract.
  • the meltable wall 7A and the stopper 7 are melted when the coil heaters 16 and 17 are turned on, so that the medicines in the medicine chambers 3a_l and 3a_2 can be mixed, and the first space 3a becomes the dosing opening 6 It is opened to the outside through.
  • the agonists 19a and 19b in the agonist chambers 3b_l and 3b_2 are mixed.
  • the volume of the agonists 19a and 19b expands and the pressure in the second space 3b is increased, so that the movable wall 5 is moved toward the dosing opening 6 side.
  • the drugs 8a and 8b in the first space 3a are released to the outside through the dosing opening 6 while being mixed.
  • the capsule-type medication device B when the operator transmits a medication command through the remote control system, the capsule-type medication device B turns on the coiled heaters 16 and 17 to melt the meltable wall 7A and the plug 7 As a result, the drug is administered into the digestive tract.
  • the drug since the variation in the timing at which the stopper 7 melts can be reduced, the drug can be reliably administered to a desired site by precisely controlling the timing of dosing.
  • the meltable wall 7A made from beef tallow is extended from the second space 3b to the first space 3a, and the meltable wall 7A and the plug 7 are formed as a single piece, so that they can be melted simultaneously. As a result, the medication opening 6 can be reliably opened and the drug can be smoothly administered into the digestive tract.
  • meltable wall 7A partitions the first space 3a into the drug chambers 3a_l and 3a_2, different drugs that are preferably separated in advance can be stored in the drug chambers 3a_l and 3a_2, respectively. Can be applied simultaneously to the site.
  • the capsule dosing device B includes only the coiled heater 17. This embodiment is effective when the meltable wall 7A and the plug 7 can be melted only by the coil heater 17. In this case, since the conductive lines 12 and 14 are not required, the production is easy.
  • the capsule dosing device B includes a timer circuit (not shown) instead of the camera 35.
  • the timer circuit is configured to wait for a desired waiting time and give a medication command to the heater drive circuit 36.
  • the subject has a capsule dosing device.
  • the heater drive circuit 36 performs a switching operation to supply power to the coiled heaters 16 and 17.
  • the medication timing can be adjusted according to the subject, so that the drug can be reliably administered to the desired site.
  • the plug 7 is formed as a separate piece separated from the meltable wall 7A.
  • This individual piece can be made of a material force that does not change with the heating temperature of the coiled heaters 16 and 17, for example.
  • the meltable wall 7A is melted by the heat generated by the coil heaters 16 and 17, and the working chemicals 19a and 19b are mixed to expand the volume.
  • the movable wall 5 is moved to the side of the medication opening 6 and the pressure in the first space 3a is increased, so that the stopper 7 is pushed out, and subsequently the medications 8a and 8b in the medication chambers 3a_l and 3a_2 are dispensed.
  • the gastrointestinal tract Through the gastrointestinal tract.
  • the plug 7 (individual piece) may be made from a material that is melted at the melting point.
  • the surface of the stopper 7 is melted by the heat generated by the coiled heater 16, and the gap between the stopper 7 and the dosing opening 6 is increased, so that the stopper 7 can be easily removed, and the medicine is reliably delivered to the desired site. Can be administered.

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  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif de type capsule pour administrer un médicament, qui possède une capsule, un espace de réception ayant une ouverture d'administration de médicament, un médicament reçu à l'intérieur de l'espace de réception, un bouchon pour fermer l'ouverture d'administration de médicament, une paroi mobile et un système de commande. La paroi mobile est placée de façon mobile dans l'espace de réception et peut diviser l'espace en un premier espace et un second espace. Le premier espace contient l'ouverture d'administration de médicament et reçoit le médicament. Selon une commande d'administration de médicament, le système de commande retire le bouchon de l'ouverture d'administration de médicament, déplace la paroi mobile vers le côté d'ouverture d'administration, et administre le médicament dans un tube digestif.
PCT/JP2007/071513 2006-11-17 2007-11-06 Dispositif de type capsule pour administrer un médicament Ceased WO2008059728A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006-312029 2006-11-17
JP2006312029A JP2008125641A (ja) 2006-11-17 2006-11-17 投薬装置
JP2006-312030 2006-11-17
JP2006312030A JP2008125642A (ja) 2006-11-17 2006-11-17 投薬装置

Publications (1)

Publication Number Publication Date
WO2008059728A1 true WO2008059728A1 (fr) 2008-05-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/071513 Ceased WO2008059728A1 (fr) 2006-11-17 2007-11-06 Dispositif de type capsule pour administrer un médicament

Country Status (1)

Country Link
WO (1) WO2008059728A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011018743A1 (fr) 2009-08-12 2011-02-17 Koninklijke Philips Electronics N.V. Reservoir de medicament pour dispositif d'administration de medicament
JP2012522616A (ja) * 2009-04-07 2012-09-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ モジュラ経口摂取医薬品供給カプセル
WO2014053352A1 (fr) 2012-10-03 2014-04-10 Danmarks Tekniske Universitet Capsule pouvant être ingérée pour libération contrôlée à distance d'une substance
JP2016531623A (ja) * 2013-09-26 2016-10-13 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 閾値放出を有する送達カプセル
CN116269518A (zh) * 2023-03-06 2023-06-23 华中科技大学 具有可控给药和活检功能的磁控胶囊机器人及其制作方法

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WO2005030114A1 (fr) * 2003-09-29 2005-04-07 Olympus Corporation Systeme de dosage a capsule, methode de dosage comprenant l'utilisation de ce systeme, et procede de commande pour ce systeme de dosage a capsule
JP2005143991A (ja) * 2003-11-18 2005-06-09 Olympus Corp カプセル型医療システム
JP2005185567A (ja) * 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
JP2006061399A (ja) * 2004-08-26 2006-03-09 Hitachi Ltd 検査カプセル及び検査システム

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030114A1 (fr) * 2003-09-29 2005-04-07 Olympus Corporation Systeme de dosage a capsule, methode de dosage comprenant l'utilisation de ce systeme, et procede de commande pour ce systeme de dosage a capsule
JP2005143991A (ja) * 2003-11-18 2005-06-09 Olympus Corp カプセル型医療システム
JP2005185567A (ja) * 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
JP2006061399A (ja) * 2004-08-26 2006-03-09 Hitachi Ltd 検査カプセル及び検査システム

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012522616A (ja) * 2009-04-07 2012-09-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ モジュラ経口摂取医薬品供給カプセル
WO2011018743A1 (fr) 2009-08-12 2011-02-17 Koninklijke Philips Electronics N.V. Reservoir de medicament pour dispositif d'administration de medicament
CN102811762A (zh) * 2009-08-12 2012-12-05 皇家飞利浦电子股份有限公司 用于药物输送装置的药物容器
JP2013501568A (ja) * 2009-08-12 2013-01-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 薬品送出装置のための医薬貯槽
CN102811762B (zh) * 2009-08-12 2014-08-27 皇家飞利浦电子股份有限公司 用于药物输送装置的药物容器
US8852155B2 (en) 2009-08-12 2014-10-07 Medimetrics Personalized Drug Delivery Medicine reservoir for drug delivery device
WO2014053352A1 (fr) 2012-10-03 2014-04-10 Danmarks Tekniske Universitet Capsule pouvant être ingérée pour libération contrôlée à distance d'une substance
JP2016531623A (ja) * 2013-09-26 2016-10-13 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 閾値放出を有する送達カプセル
CN116269518A (zh) * 2023-03-06 2023-06-23 华中科技大学 具有可控给药和活检功能的磁控胶囊机器人及其制作方法

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