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WO2008059252A3 - Methods and composition fro t cell receptors which recognize 5t4 antigen - Google Patents

Methods and composition fro t cell receptors which recognize 5t4 antigen Download PDF

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Publication number
WO2008059252A3
WO2008059252A3 PCT/GB2007/004361 GB2007004361W WO2008059252A3 WO 2008059252 A3 WO2008059252 A3 WO 2008059252A3 GB 2007004361 W GB2007004361 W GB 2007004361W WO 2008059252 A3 WO2008059252 A3 WO 2008059252A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
recognize
fro
cell receptors
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/004361
Other languages
French (fr)
Other versions
WO2008059252A2 (en
WO2008059252A9 (en
Inventor
Kevin Myers
Irina Redchenko
William Shingler
Richard Harrop
Stuart Naylor
Alan Kingsman
Susan Kingsman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0622805A external-priority patent/GB0622805D0/en
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Publication of WO2008059252A2 publication Critical patent/WO2008059252A2/en
Publication of WO2008059252A9 publication Critical patent/WO2008059252A9/en
Publication of WO2008059252A3 publication Critical patent/WO2008059252A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
PCT/GB2007/004361 2006-11-15 2007-11-15 Methods and composition fro t cell receptors which recognize 5t4 antigen Ceased WO2008059252A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86601206P 2006-11-15 2006-11-15
US60/866,012 2006-11-15
GB0622805A GB0622805D0 (en) 2006-11-15 2006-11-15 Methods and compositions for T cell receptors which recognize 5T4 antigen
GB0622805.0 2006-11-15

Publications (3)

Publication Number Publication Date
WO2008059252A2 WO2008059252A2 (en) 2008-05-22
WO2008059252A9 WO2008059252A9 (en) 2008-09-18
WO2008059252A3 true WO2008059252A3 (en) 2008-12-04

Family

ID=39235985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/004361 Ceased WO2008059252A2 (en) 2006-11-15 2007-11-15 Methods and composition fro t cell receptors which recognize 5t4 antigen

Country Status (1)

Country Link
WO (1) WO2008059252A2 (en)

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AU2009278386B2 (en) 2008-08-05 2015-05-21 Toray Industries, Inc. Pharmaceutical composition for treatment and prevention of cancers
WO2011096533A1 (en) 2010-02-04 2011-08-11 東レ株式会社 Pharmaceutical composition for treatment and/or prevention of cancer
MX340014B (en) 2010-02-04 2016-06-22 Toray Industries Pharmaceutical composition for treatment and/or prevention of cancer.
BR112012018943A8 (en) 2010-02-04 2017-12-19 Toray Industries medicine and method for treating and / or preventing cancer
RU2567657C2 (en) 2010-02-04 2015-11-10 Торэй Индастриз, Инк. Pharmaceutical composition for treating and/or preventing cancer
RU2598258C2 (en) 2010-02-04 2016-09-20 Торэй Индастриз, Инк. Pharmaceutical composition for treatment and/or prevention of cancer
CA2788718C (en) 2010-02-04 2019-05-21 Shinichi Kobayashi Caprin-1 antibody for treating and/or preventing cancer
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CA2844033C (en) 2011-08-04 2021-07-27 Toray Industries, Inc. Method for detecting pancreatic cancer
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MX360208B (en) 2012-02-21 2018-10-24 Toray Industries Pharmaceutical composition for treatment and/or prevention of cancer.
PT2818481T (en) 2012-02-21 2019-10-25 Toray Industries Pharmaceutical composition for treatment and/or prevention of cancer
WO2013125654A1 (en) 2012-02-21 2013-08-29 東レ株式会社 Medicinal composition for treating and/or preventing cancer
AU2013223147B2 (en) 2012-02-21 2017-10-05 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
JP6107655B2 (en) 2012-03-30 2017-04-05 東レ株式会社 Pharmaceutical composition for treatment and / or prevention of gallbladder cancer
EP2832365B1 (en) 2012-03-30 2017-11-01 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of liver cancer
RU2646464C2 (en) 2012-07-19 2018-03-05 Торэй Индастриз, Инк. Method for cancer detection
PT2876446T (en) 2012-07-19 2019-03-25 Toray Industries Method for detecting cancer
PT3031826T (en) 2013-08-09 2019-01-18 Toray Industries Pharmaceutical composition for treatment and/or prevention of cancer
CN106916227B (en) * 2015-12-24 2019-12-13 凯惠科技发展(上海)有限公司 A kind of TPBG antibody and its preparation method, its conjugate and application
WO2019109047A1 (en) * 2017-12-01 2019-06-06 Fred Hutchinson Cancer Research Center Binding proteins specific for 5t4 and uses thereof
EP4656196A2 (en) 2018-05-11 2025-12-03 Memorial Sloan-Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
WO2019217831A1 (en) * 2018-05-11 2019-11-14 Memorial Sloan-Kettering Cancer Center Methods for identifying antigen-specific t cell receptors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816496A2 (en) * 1996-06-24 1998-01-07 Roche Diagnostics GmbH T-cells specific for kidney carcinoma
GB2370572A (en) * 1998-11-18 2002-07-03 Oxford Biomedica Ltd Use of professional antigen presenting cells
WO2003068816A1 (en) * 2002-02-13 2003-08-21 Oxford Biomedica Uk Limited Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen
WO2004060145A2 (en) * 2002-12-31 2004-07-22 Baylor College Of Medicine Isolation and identification of cross-reactive t cells
WO2005062959A2 (en) * 2003-12-22 2005-07-14 The University Of Tennessee Research Foundation Isolated t lymphocyte receptors specific for human autoantigens complexed with human mhc molecules and methods of making and using same
WO2006120473A2 (en) * 2005-05-13 2006-11-16 Oxford Biomedica (Uk) Limited Mhc class i and ii peptide antigens derived from tumour antigen 5t4

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816496A2 (en) * 1996-06-24 1998-01-07 Roche Diagnostics GmbH T-cells specific for kidney carcinoma
GB2370572A (en) * 1998-11-18 2002-07-03 Oxford Biomedica Ltd Use of professional antigen presenting cells
WO2003068816A1 (en) * 2002-02-13 2003-08-21 Oxford Biomedica Uk Limited Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen
WO2004060145A2 (en) * 2002-12-31 2004-07-22 Baylor College Of Medicine Isolation and identification of cross-reactive t cells
WO2005062959A2 (en) * 2003-12-22 2005-07-14 The University Of Tennessee Research Foundation Isolated t lymphocyte receptors specific for human autoantigens complexed with human mhc molecules and methods of making and using same
WO2006120473A2 (en) * 2005-05-13 2006-11-16 Oxford Biomedica (Uk) Limited Mhc class i and ii peptide antigens derived from tumour antigen 5t4

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLAY T ET AL: "Efficient transfer of a tumor antigen reactive TCR to human peripheral blood lymphocytes confers anti tumor reactivity", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 163, 1 January 1999 (1999-01-01), pages 507 - 513, XP002169636, ISSN: 0022-1767 *
ENGELS BORIS ET AL: "Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes", HUMAN GENE THERAPY, MARY ANN LIEBERT, NEW YORK ,NY, US, vol. 16, no. 7, 1 July 2005 (2005-07-01), pages 799 - 810, XP002460992, ISSN: 1043-0342 *
REDCHENKO IRINA ET AL: "IDENTIFICATION OF THE FIRST CD8+ T CELL EPITOPE WITHIN TUMOR-ASSOCIATED ANTIGEN 5T4", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATIONFOR CANCER RESEARCH, NEW YORK, NY, vol. 44, 14 July 2003 (2003-07-14), pages 361,ABSTRACT1857, XP008072044, ISSN: 0197-016X *
SMYTH L J C ET AL: "CD8 T-cell recognition of human 5T4 oncofetal antigen", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 119, no. 7, 1 October 2006 (2006-10-01), pages 1638 - 1647, XP002409262, ISSN: 0020-7136 *
ZHAO YANGBING ET AL: "Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 174, no. 7, 1 April 2005 (2005-04-01), pages 4415 - 4423, XP002343301, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008059252A2 (en) 2008-05-22
WO2008059252A9 (en) 2008-09-18

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