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WO2008053304A3 - Processes for the preparation of a stable polymorphic form of entacapone - Google Patents

Processes for the preparation of a stable polymorphic form of entacapone Download PDF

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Publication number
WO2008053304A3
WO2008053304A3 PCT/IB2007/003233 IB2007003233W WO2008053304A3 WO 2008053304 A3 WO2008053304 A3 WO 2008053304A3 IB 2007003233 W IB2007003233 W IB 2007003233W WO 2008053304 A3 WO2008053304 A3 WO 2008053304A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
entacapone
processes
polymorphic form
stable polymorphic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/003233
Other languages
French (fr)
Other versions
WO2008053304A2 (en
Inventor
Ram Prasad Yadav
Zakir Gafoor Shaikh
Siddiqui Mohammed Jaweed Mukarram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Research Centre
Original Assignee
Wockhardt Research Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Centre filed Critical Wockhardt Research Centre
Publication of WO2008053304A2 publication Critical patent/WO2008053304A2/en
Publication of WO2008053304A3 publication Critical patent/WO2008053304A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The invention relates to processes for the preparation of a stable polymorphic form of entacapone. More particularly, it relates to the preparation of stable polymorphic form designated as Form D. The invention also relates to an improved process for the preparation of 2-cyano-N,N-diethylacetamide, and to the use of this compound as an intermediate for the preparation of entacapone.
PCT/IB2007/003233 2006-10-30 2007-10-26 Processes for the preparation of a stable polymorphic form of entacapone Ceased WO2008053304A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1790/MUM/2006 2006-10-30
IN1792MU2006 2006-10-30
IN1792/MUM/2006 2006-10-30
IN1790MU2006 2006-10-30

Publications (2)

Publication Number Publication Date
WO2008053304A2 WO2008053304A2 (en) 2008-05-08
WO2008053304A3 true WO2008053304A3 (en) 2009-04-23

Family

ID=39344654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003233 Ceased WO2008053304A2 (en) 2006-10-30 2007-10-26 Processes for the preparation of a stable polymorphic form of entacapone

Country Status (1)

Country Link
WO (1) WO2008053304A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061259A (en) * 2015-08-25 2015-11-18 重庆植恩药业有限公司 Preparing method for entacapone A-type crystals

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7385072B2 (en) * 2003-12-29 2008-06-10 Suven Life Sciences Methods for the preparation of Entacapone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7385072B2 (en) * 2003-12-29 2008-06-10 Suven Life Sciences Methods for the preparation of Entacapone

Also Published As

Publication number Publication date
WO2008053304A2 (en) 2008-05-08

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