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WO2008052016A3 - Récepteur associé à la sortiline sorl1 présentant un lien fonctionnel et génétique avec la maladie d'alzheimer - Google Patents

Récepteur associé à la sortiline sorl1 présentant un lien fonctionnel et génétique avec la maladie d'alzheimer Download PDF

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Publication number
WO2008052016A3
WO2008052016A3 PCT/US2007/082308 US2007082308W WO2008052016A3 WO 2008052016 A3 WO2008052016 A3 WO 2008052016A3 US 2007082308 W US2007082308 W US 2007082308W WO 2008052016 A3 WO2008052016 A3 WO 2008052016A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
alzheimer
sortilin
functionally
related receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/082308
Other languages
English (en)
Other versions
WO2008052016A2 (fr
Inventor
Richard Mayeux
Ekaterina Rogaeva
George-Hyslop Peter St
Lindsay Farrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of WO2008052016A2 publication Critical patent/WO2008052016A2/fr
Publication of WO2008052016A3 publication Critical patent/WO2008052016A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés permettant de déterminer si un patient présente un risque de développer la maladie d'Alzheimer en analysant l'ADN du patient et en déterminant si des variants nucléotidiques se situent dans la région du gène pour SORL1 au niveau des sites SNP 4 ou 8-12 et 19-26.
PCT/US2007/082308 2006-10-23 2007-10-23 Récepteur associé à la sortiline sorl1 présentant un lien fonctionnel et génétique avec la maladie d'alzheimer Ceased WO2008052016A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85384106P 2006-10-23 2006-10-23
US60/853,841 2006-10-23

Publications (2)

Publication Number Publication Date
WO2008052016A2 WO2008052016A2 (fr) 2008-05-02
WO2008052016A3 true WO2008052016A3 (fr) 2008-07-31

Family

ID=39325361

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/082308 Ceased WO2008052016A2 (fr) 2006-10-23 2007-10-23 Récepteur associé à la sortiline sorl1 présentant un lien fonctionnel et génétique avec la maladie d'alzheimer

Country Status (1)

Country Link
WO (1) WO2008052016A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016164608A1 (fr) 2015-04-07 2016-10-13 Alector Llc Procédés de recherche par criblage d'antagonistes de liaison à la sortiline
SMT202200065T1 (it) 2015-04-07 2022-03-21 Alector Llc Anticorpi anti-sortilina e loro metodi d'impiego
MY202133A (en) 2018-07-13 2024-04-05 Alector Llc Anti-sortilin antibodies and methods of use thereof
WO2023275376A1 (fr) * 2021-07-02 2023-01-05 Aarhus Universitet Méthodes de traitement de la maladie d'alzheimer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106573A1 (en) * 2003-11-13 2005-05-19 Council Of Scientific And Industrial Research Method of detection of predisposition to high altitude pulmonary edema (HAPE)
US20050177881A1 (en) * 2001-12-04 2005-08-11 Andreas Papassotiropoulos Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determining single nucleotide polymorphisms
US20060134664A1 (en) * 2004-11-03 2006-06-22 Scherzer Clemens R Identification of dysregulated genes in patients with neurological diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050177881A1 (en) * 2001-12-04 2005-08-11 Andreas Papassotiropoulos Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determining single nucleotide polymorphisms
US20050106573A1 (en) * 2003-11-13 2005-05-19 Council Of Scientific And Industrial Research Method of detection of predisposition to high altitude pulmonary edema (HAPE)
US20060134664A1 (en) * 2004-11-03 2006-06-22 Scherzer Clemens R Identification of dysregulated genes in patients with neurological diseases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 25 May 2006 (2006-05-25), Database accession no. (rs560573) *
DATABASE GENBANK [online] 25 May 2006 (2006-05-25), Database accession no. (rs593769) *
DATABASE GENBANK [online] 25 May 2006 (2006-05-25), Database accession no. (rs985421) *
ROGAEVA ET AL.: "The Neuronal Sortilin-Related Receptor SORL1 is Genetically Associated with Alzheimer Disease", NATURE GENETICS, vol. 39, no. 2, February 2007 (2007-02-01), pages 168 - 177, XP055050412, DOI: doi:10.1038/ng1943 *

Also Published As

Publication number Publication date
WO2008052016A2 (fr) 2008-05-02

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