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WO2008052088A8 - Chromane derivatives, synthesis thereof, and intermediates thereto - Google Patents

Chromane derivatives, synthesis thereof, and intermediates thereto

Info

Publication number
WO2008052088A8
WO2008052088A8 PCT/US2007/082452 US2007082452W WO2008052088A8 WO 2008052088 A8 WO2008052088 A8 WO 2008052088A8 US 2007082452 W US2007082452 W US 2007082452W WO 2008052088 A8 WO2008052088 A8 WO 2008052088A8
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
synthesis
compounds
chromane derivatives
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/082452
Other languages
French (fr)
Other versions
WO2008052088A1 (en
Inventor
Youchu Wang
Chia-Cheng Shaw
Xianghui Wen
Virginie Guillemette
Luc Bouchard
Sylvain Daigneault
Warren Chew
Sam Tadyson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of WO2008052088A1 publication Critical patent/WO2008052088A1/en
Publication of WO2008052088A8 publication Critical patent/WO2008052088A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Methods of preparing compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
PCT/US2007/082452 2006-10-25 2007-10-24 Chromane derivatives, synthesis thereof, and intermediates thereto Ceased WO2008052088A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85438206P 2006-10-25 2006-10-25
US60/854,382 2006-10-25

Publications (2)

Publication Number Publication Date
WO2008052088A1 WO2008052088A1 (en) 2008-05-02
WO2008052088A8 true WO2008052088A8 (en) 2008-09-25

Family

ID=39029809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/082452 Ceased WO2008052088A1 (en) 2006-10-25 2007-10-24 Chromane derivatives, synthesis thereof, and intermediates thereto

Country Status (5)

Country Link
AR (1) AR063372A1 (en)
CL (1) CL2007003066A1 (en)
PE (1) PE20081139A1 (en)
TW (1) TW200831478A (en)
WO (1) WO2008052088A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009063992A1 (en) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited Condensed pyridine derivative and use thereof
EP2510949A4 (en) 2009-12-11 2013-11-13 Astellas Pharma Inc Therapeutic agent for fibromyalgia
CN102329199B (en) * 2011-07-19 2014-04-02 黑龙江大学 Method for synthesizing biphenyl compounds under composite catalytic actions of Pd/C and crown ether
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN103553859B (en) * 2013-11-14 2015-09-16 竺叶洪 A kind of method being prepared aminated compounds intermediate by acid amides
WO2016020440A1 (en) * 2014-08-06 2016-02-11 Interquim, S.A. Method for the synthesis of mirabegron and its derivatives
CN104591939B (en) * 2015-01-31 2016-06-15 台州学院 A kind of method preparing xenyl acrylic acid ether compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (en) * 1991-10-28 1993-04-29 Bayer Ag 2-AMINOMETHYL-chromans
JP2005505586A (en) * 2001-10-04 2005-02-24 ワイス Chroman derivatives as 5-hydroxytryptamine-6 ligands
WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
US6667322B2 (en) * 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
PE20061297A1 (en) * 2005-04-22 2006-12-24 Wyeth Corp CHROME AND CHROME DERIVED COMPOUNDS MODULATING THE SEROTONIN 5-HT2C RECEPTOR

Also Published As

Publication number Publication date
WO2008052088A1 (en) 2008-05-02
AR063372A1 (en) 2009-01-21
PE20081139A1 (en) 2008-09-18
TW200831478A (en) 2008-08-01
CL2007003066A1 (en) 2008-01-25

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