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WO2008046584A3 - Lepa as a target for antibacterial agents - Google Patents

Lepa as a target for antibacterial agents Download PDF

Info

Publication number
WO2008046584A3
WO2008046584A3 PCT/EP2007/008961 EP2007008961W WO2008046584A3 WO 2008046584 A3 WO2008046584 A3 WO 2008046584A3 EP 2007008961 W EP2007008961 W EP 2007008961W WO 2008046584 A3 WO2008046584 A3 WO 2008046584A3
Authority
WO
WIPO (PCT)
Prior art keywords
lepa
target
antibacterial agents
methods
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/008961
Other languages
French (fr)
Other versions
WO2008046584A2 (en
Inventor
Knud H Nierhaus
Yan Qin
Daniel Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Publication of WO2008046584A2 publication Critical patent/WO2008046584A2/en
Publication of WO2008046584A3 publication Critical patent/WO2008046584A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods, substances and compositions for retarding or inhibiting cell growth by inhibiting the activity of ribosomal factor LepA. Further, methods and kits for identifying antibacterial substances are disclosed.
PCT/EP2007/008961 2006-10-16 2007-10-16 Lepa as a target for antibacterial agents Ceased WO2008046584A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06021666.0 2006-10-16
EP06021666 2006-10-16

Publications (2)

Publication Number Publication Date
WO2008046584A2 WO2008046584A2 (en) 2008-04-24
WO2008046584A3 true WO2008046584A3 (en) 2008-07-03

Family

ID=39271689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/008961 Ceased WO2008046584A2 (en) 2006-10-16 2007-10-16 Lepa as a target for antibacterial agents

Country Status (1)

Country Link
WO (1) WO2008046584A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1351059A (en) * 2000-10-26 2002-05-29 上海博德基因开发有限公司 Polypeptide-human LepA protein 12.32 and polynucleotide for coding it
WO2002056013A2 (en) * 2000-12-15 2002-07-18 Upjohn Co Oxazolidinone photoaffinity probes, uses and compounds
WO2007003410A1 (en) * 2005-07-04 2007-01-11 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Use of lepa for improving the accuracy of protein synthesis in vitro

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1351059A (en) * 2000-10-26 2002-05-29 上海博德基因开发有限公司 Polypeptide-human LepA protein 12.32 and polynucleotide for coding it
WO2002056013A2 (en) * 2000-12-15 2002-07-18 Upjohn Co Oxazolidinone photoaffinity probes, uses and compounds
WO2007003410A1 (en) * 2005-07-04 2007-01-11 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Use of lepa for improving the accuracy of protein synthesis in vitro

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CALDON C E ET AL: "Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function.", MOLECULAR MICROBIOLOGY JUL 2001, vol. 41, no. 2, July 2001 (2001-07-01), pages 289 - 297, XP002477430, ISSN: 0950-382X *
COLCA JERRY R ET AL: "Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 13 JUN 2003, vol. 278, no. 24, 13 June 2003 (2003-06-13), pages 21972 - 21979, XP002476765, ISSN: 0021-9258 *
DATABASE WPI Week 200271, Derwent World Patents Index; AN 2002-658656, XP002476769 *
DIBB N J ET AL: "lep operon proximal gene is not required for growth or secretion by Escherichia coli.", JOURNAL OF BACTERIOLOGY APR 1986, vol. 166, no. 1, April 1986 (1986-04-01), pages 83 - 87, XP002476767, ISSN: 0021-9193 *
MARCH P E ET AL: "Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 25 JUN 1985, vol. 260, no. 12, 25 June 1985 (1985-06-25), pages 7206 - 7213, XP002476764, ISSN: 0021-9258 *
QIN YAN ET AL: "The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.", CELL 17 NOV 2006, vol. 127, no. 4, 17 November 2006 (2006-11-17), pages 721 - 733, XP002477431, ISSN: 0092-8674 *
QIN: "The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome and is essential for viability at high ionic strength", 3 March 2006, QIN, BERLIN, XP002476768 *
XU JIANHUA ET AL: "Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 11 MAR 2005, vol. 328, no. 2, 11 March 2005 (2005-03-11), pages 471 - 476, XP004734330, ISSN: 0006-291X *
YOUNGMAN ELAINE M ET AL: "Ribosomal translocation: LepA does it backwards.", CURRENT BIOLOGY : CB 20 FEB 2007, vol. 17, no. 4, 20 February 2007 (2007-02-20), pages R136 - R139, XP002477432, ISSN: 0960-9822 *

Also Published As

Publication number Publication date
WO2008046584A2 (en) 2008-04-24

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