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WO2008045834A3 - Kinase inhibitors - Google Patents

Kinase inhibitors Download PDF

Info

Publication number
WO2008045834A3
WO2008045834A3 PCT/US2007/080710 US2007080710W WO2008045834A3 WO 2008045834 A3 WO2008045834 A3 WO 2008045834A3 US 2007080710 W US2007080710 W US 2007080710W WO 2008045834 A3 WO2008045834 A3 WO 2008045834A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
kinase inhibitors
methods
kinases
kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/080710
Other languages
French (fr)
Other versions
WO2008045834A2 (en
Inventor
Jason W Brown
Qing Dong
Bheema R Paraselli
Jeffrey Alan Stafford
Michael B Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda California Inc
Original Assignee
Takeda San Diego Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/539,857 external-priority patent/US8119655B2/en
Application filed by Takeda San Diego Inc filed Critical Takeda San Diego Inc
Priority to CA002666130A priority Critical patent/CA2666130A1/en
Priority to EP07868389A priority patent/EP2081930A2/en
Priority to JP2009532518A priority patent/JP2010505961A/en
Publication of WO2008045834A2 publication Critical patent/WO2008045834A2/en
Publication of WO2008045834A3 publication Critical patent/WO2008045834A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds (I) are provided for use with kinases, that comprise a compound selected from the group consisting of wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
PCT/US2007/080710 2006-10-09 2007-10-08 Kinase inhibitors Ceased WO2008045834A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002666130A CA2666130A1 (en) 2006-10-09 2007-10-08 Kinase inhibitors
EP07868389A EP2081930A2 (en) 2006-10-09 2007-10-08 Kinase inhibitors
JP2009532518A JP2010505961A (en) 2006-10-09 2007-10-08 Kinase inhibitor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/539,857 2006-10-09
US11/539,857 US8119655B2 (en) 2005-10-07 2006-10-09 Kinase inhibitors
USPCT/US2006/39667 2006-10-10
PCT/US2006/039667 WO2007044779A1 (en) 2005-10-07 2006-10-10 Kinase inhibitors
US91262507P 2007-04-18 2007-04-18
US60/912,625 2007-04-18

Publications (2)

Publication Number Publication Date
WO2008045834A2 WO2008045834A2 (en) 2008-04-17
WO2008045834A3 true WO2008045834A3 (en) 2008-07-24

Family

ID=40800472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/080710 Ceased WO2008045834A2 (en) 2006-10-09 2007-10-08 Kinase inhibitors

Country Status (3)

Country Link
EP (1) EP2081930A2 (en)
CA (1) CA2666130A1 (en)
WO (1) WO2008045834A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20090312288A1 (en) * 2008-04-16 2009-12-17 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2009129259A2 (en) * 2008-04-16 2009-10-22 Takeda Pharmaceutical Company Limited Polymorphs of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide and methods of use therefor
EP2283014A1 (en) * 2008-04-16 2011-02-16 Takeda Pharmaceutical Company Limited Polymorphs of hydrochloride salt o5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n-(1-methylpiperidin-4-yl)-9h-pyridoý2,3-b¨indole-7-carboxamideand methods of use therefor
US8501765B2 (en) 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
FR2950891B1 (en) * 2009-10-06 2012-11-09 Sanofi Aventis AZACARBOLINE DERIVATIVES 9H-PYRROLO [2,3-B: 5,4-C] DIPYRIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
US20110183938A1 (en) 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
CN115353484A (en) * 2022-07-05 2022-11-18 西北师范大学 A kind of synthetic method of 4-position amino-substituted carbazole, dibenzo[b, d]furan and fluorene derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1367058A1 (en) * 2002-05-31 2003-12-03 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydropyran derivatives
WO2005123672A2 (en) * 2004-06-14 2005-12-29 Takeda San Diego, Inc. Kinase inhibitors
WO2006040451A2 (en) * 2004-10-11 2006-04-20 Universite Claude Bernard Lyon I Novel 9h-pyrido[2,3-b]indole derivatives serving as cdk and gsk3 inhibitors, method for the preparation thereof, and the pharmaceutical compositions containing such compounds
WO2006131552A1 (en) * 2005-06-09 2006-12-14 Boehringer Ingelheim International Gmbh Alpha-carbolines as cdk-1 inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1367058A1 (en) * 2002-05-31 2003-12-03 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydropyran derivatives
WO2005123672A2 (en) * 2004-06-14 2005-12-29 Takeda San Diego, Inc. Kinase inhibitors
WO2006040451A2 (en) * 2004-10-11 2006-04-20 Universite Claude Bernard Lyon I Novel 9h-pyrido[2,3-b]indole derivatives serving as cdk and gsk3 inhibitors, method for the preparation thereof, and the pharmaceutical compositions containing such compounds
WO2006131552A1 (en) * 2005-06-09 2006-12-14 Boehringer Ingelheim International Gmbh Alpha-carbolines as cdk-1 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BHATTI, INAYAT A. ET AL: "Pyrolysis of 1-substituted pyrazoles and chloroform at 550 .degree.C: formation of .alpha.-carboline from 1-benzylpyrazoles", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY , (24), 3581-3586 CODEN: JCPRB4; ISSN: 0300-922X, 1997, XP002417212 *
MEHTA LINA K ET AL: "THE ELIMINATION OF AN ALKOXY GROUP IN THE PHOTO-GRAEBE-ULLMANN CONVERSION OF 1-(2,5-DIALKOXYPHENYL)TRIAZOLOPYRIDINES INTO CARBOLINES, AND THE PREPARATION OF.ALPHA.-,.GAMMA.- AND.DELTA.-CARBOLINE QUINONES", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, vol. 11, 1993, pages 1261 - 1267, XP009077814, ISSN: 0300-922X *

Also Published As

Publication number Publication date
EP2081930A2 (en) 2009-07-29
CA2666130A1 (en) 2008-04-17
WO2008045834A2 (en) 2008-04-17

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