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WO2008042806A3 - Dérivés d'acide stilbènedisulfonique comme inhibiteurs de l'intégrase rétrovirale - Google Patents

Dérivés d'acide stilbènedisulfonique comme inhibiteurs de l'intégrase rétrovirale Download PDF

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Publication number
WO2008042806A3
WO2008042806A3 PCT/US2007/079980 US2007079980W WO2008042806A3 WO 2008042806 A3 WO2008042806 A3 WO 2008042806A3 US 2007079980 W US2007079980 W US 2007079980W WO 2008042806 A3 WO2008042806 A3 WO 2008042806A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid derivatives
stilbenedisulfonic acid
inhibitors
retroviral integrase
retroviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/079980
Other languages
English (en)
Other versions
WO2008042806A2 (fr
Inventor
Yves Pommier
Elena Semenova
Christophe Marchand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of WO2008042806A2 publication Critical patent/WO2008042806A2/fr
Publication of WO2008042806A3 publication Critical patent/WO2008042806A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une classe de nouveaux dérivés d'acide stilbènedisulfonique. Ces composés ont une activité d'inhibiteurs de l'intégrase rétrovirale, une enzyme essentielle pour la prolifération de rétrovirus tels que le VIH-1. L'invention décrit également des compositions pharmaceutiques comportant au moins un des dérivés d'acide stilbènedisulfonique et un procédé d'utilisation des dérivés d'acide stilbènedisulfonique pour empêcher une prolifération rétrovirale. De plus, l'invention fournit un nouveau procédé pour identifier des composés qui empêchent l'activité d'une intégrase de rétrovirus.
PCT/US2007/079980 2006-10-04 2007-09-28 Dérivés d'acide stilbènedisulfonique comme inhibiteurs de l'intégrase rétrovirale Ceased WO2008042806A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84971806P 2006-10-04 2006-10-04
US60/849,718 2006-10-04

Publications (2)

Publication Number Publication Date
WO2008042806A2 WO2008042806A2 (fr) 2008-04-10
WO2008042806A3 true WO2008042806A3 (fr) 2008-12-24

Family

ID=38969991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079980 Ceased WO2008042806A2 (fr) 2006-10-04 2007-09-28 Dérivés d'acide stilbènedisulfonique comme inhibiteurs de l'intégrase rétrovirale

Country Status (1)

Country Link
WO (1) WO2008042806A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088513A2 (fr) 2010-12-23 2012-06-28 Fox Chase Cancer Center Inhibition d'intégration d'adn rétroviral dans adn de cellule hôte et dépistage de composés aptes à cette inhibition
EP2599480A1 (fr) * 2011-12-03 2013-06-05 Universität Innsbruck Compositions pour le traitement de la grippe

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022610A1 (fr) * 1991-06-14 1992-12-23 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Derives de colorants azoiques presentant une efficacite anti-vih

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022610A1 (fr) * 1991-06-14 1992-12-23 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Derives de colorants azoiques presentant une efficacite anti-vih

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GRUSZECKA-KOWALIK EWA ET AL: "Quinobene, a new potent anti-HIV agent", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 187, no. 3, 1 January 1992 (1992-01-01), pages 1409 - 1417, XP001249147, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2008042806A2 (fr) 2008-04-10

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