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WO2008042669A1 - Dispositif ultrasonique d'administration de liquides et procédés d'utilisation de l'énergie ultrasonique pour administrer des liquides dans le corps - Google Patents

Dispositif ultrasonique d'administration de liquides et procédés d'utilisation de l'énergie ultrasonique pour administrer des liquides dans le corps Download PDF

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Publication number
WO2008042669A1
WO2008042669A1 PCT/US2007/079552 US2007079552W WO2008042669A1 WO 2008042669 A1 WO2008042669 A1 WO 2008042669A1 US 2007079552 W US2007079552 W US 2007079552W WO 2008042669 A1 WO2008042669 A1 WO 2008042669A1
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Prior art keywords
horn
distal end
grommet
proximal end
liquid
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PCT/US2007/079552
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English (en)
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WO2008042669A8 (fr
Inventor
Eilaz Babaev
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Individual
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Individual
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Filing date
Publication date
Priority claimed from US11/536,911 external-priority patent/US20080082039A1/en
Priority claimed from US11/536,928 external-priority patent/US8050752B2/en
Application filed by Individual filed Critical Individual
Priority to JP2009530577A priority Critical patent/JP2010509944A/ja
Priority to AU2007304952A priority patent/AU2007304952A1/en
Priority to EP07815003A priority patent/EP2068809A1/fr
Publication of WO2008042669A1 publication Critical patent/WO2008042669A1/fr
Publication of WO2008042669A8 publication Critical patent/WO2008042669A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the present invention relates to an ultrasound liquid delivery device and methods of using ultrasonic energy useful for introducing liquids into the body.
  • maladies infections, conditions, ailments, and diseases (hereafter collectively referred to as "maladies") of the body are difficult to treat pharmacologically due to inaccessibility of the site of the malady to pharmacologically active compounds (commonly referred to as “drugs”) such as, but not limited to, chemical compounds, chemicals, small molecules, proteins, genes, and/or any combination thereof.
  • pharmacologically active compounds commonly referred to as “drugs”
  • Such sites include body lumens and body cavities such as, but not limited to, the urethra, sinuses, vagina, uterus, outer ear, lungs, thoracic cavity, and colon, and poorly vasculated tissue such as, but not limited, to bones.
  • a pill containing the drug is first dissolved in the stomach and/or small intestine after being swallowed, thereby liberating small drug molecules.
  • the small drug molecules are then carried into the cells forming the walls of the small intestine by transport molecules on the cells' surfaces.
  • the drug may pass directly into the cells of the small intestine on their own by either diffusing through cellular membranes or passing through pores located within the cellular membranes.
  • the drug molecules are transported by similar mechanisms into the patient's blood stream.
  • the drug molecules then spread throughout the patient's entire blood stream where they are subjected to degradation and/or inactivation by various elements within the blood.
  • the blood stream also transports the drug molecules to potential sites of degradation, inactivation, and/or excretion such as, but not limited to, the kidneys and liver. Despite dilution by wide spread distribution, inactivation, degradation, and/or excretion, some of the drug molecules reach areas of the blood stream adjacent to the urethra.
  • the drug must by taken out of the bloodstream by the cells forming the urethra and then deposited into the open space of the urethra. Drug molecules may also reach the urethra by excretion into the urine, which flows through the open space of the urethra. Unfortunately, the urine is not kept at a constant pH, and may become sufficiently acidic or basic as to inactivate and/or degrade the drug molecules. [0004] With respect to maladies within poorly vasculated and/or perfused tissue, pharmacological treatment is limited by a poor blood supply.
  • Catheter drug delivery methods and devices have been developed to overcome the limitations of pharmacological treatment. Inserting catheters into lumens or body cavities and injecting a drug through or from the catheters gives pharmacologically active compounds access to the site of a malady. Running a catheter through a small or narrow body lumen, such as the urethra, can be uncomfortable for the patient. Inflicting injury while inserting the catheter can create serious complications such as allowing an infection on the inner wall of the lumen or body cavity to enter the blood stream, thereby spreading the infection throughout the body. Furthermore, finding the site of the malady to be treated, while inserting the catheter, can be difficult.
  • creams and other medical ointments have been developed.
  • the cream or ointment is spread on the walls of the cavity with a finger, swab, or similar device. Though these creams and ointments can be effective, their use is generally not preferred by the patient as they can be messy, leak out, and are often unpleasant to apply.
  • Delivering drugs to open body cavities and/or lumens not sufficiently accessible as to permit the application of creams, such as the sinuses has been accomplished with various spray and/or misting devices. Exemplar devices well known in the art are nasal sprays and inhalers.
  • 6,601,581 to the present inventor describes an ultrasound inhaler utilizing ultrasonic energy to create a fine drug mist. Though effective at delivering drugs to the lungs and bronchia, this device is incapable of creating a spray of sufficient velocity to enable drug delivery deep within lumens and cavities of the body. [0010] Though drugs are often effective in treating various maladies of the body, they are not always necessary. Many maladies of the body can be treated simply by washing and/or flushing the affected area. Washing and/or flushing with simple, drug free fluids such as, but not limited to, saline or water has the benefit of avoiding the various side effects and complications drugs may possess.
  • the present invention relates to an ultrasound liquid delivery device comprising an ultrasound transducer, an ultrasound horn, a channel running at least partially through said horn, and a dampening grommet at the distal end of the horn.
  • the device of the present invention may further comprise a liquid supply emptying into said channel. Liquids within the channel of the ultrasound horn are subjected to ultrasonic energy emanating from the horn, causing the velocity of the liquid to be accelerated as to produce a higher velocity, low pressure liquid stream.
  • the present invention enables liquid delivery deep into lumens, cavities, and tissues of the body.
  • Treating maladies of lumens, cavities, and/or tissues of the body with the present invention entails first selecting an appropriate liquid.
  • a liquid comprising a pharmaceutically active compound, or drug, with properties known or believed to treat the malady present may be advantageous.
  • the liquid chosen may possess properties ideal for washing the lumen, cavity, and/or tissue to be treated (hereafter referred to as the "treatment area") of contaminants, infectious microbes, bacteria, funguses, accretions, impacted matter, dirt, debris, necrotic tissue, and/or other undesirable elements.
  • Choosing a liquid capable of coupling the inner channel of the horn with the treatment area as to allow for the transmission of ultrasonic energy released into the inner channel of the horn to the treatment area may also prove advantageous.
  • the coupled ultrasonic energy may induce cavitations within the treatment area.
  • the coupled ultrasonic energy may help to dissolve accretions, remove undesirable elements from the treatment area, promote the growth of healthy tissue within the treatment area, retard the growth of and/or kill unwanted tissue within the treatment area, retard the growth of and/or kill infectious microbes within the treatment area, enhance the entry of drugs into cells within and in the vicinity of the treatment area, and/or provide other positive healing benefits.
  • the liquid chosen may possess all or some of the above mentioned properties.
  • the ultrasound liquid delivery device of the present invention may also be used for preventative purposes.
  • the present invention may be used to wash the treatment area as to prevent and/or lessen the likelihood of developing a malady within the treatment area.
  • Delivering liquids comprising vitamins, minerals, drugs, and/or other elements known and/or believed to have a positive effect on the treatment area may also help to preserve proper functioning of the treatment area and prevent the development of maladies therein.
  • Preventing biological processes from occurring within the treatment area such as, but not limited, ovulation, fertilization, and/or implantation, may also be accomplished by using the present invention to deliver to the treatment area liquids possessing properties known and/or believed to retard the undesired processes.
  • inducing the occurrence of wanted biological processes may be accomplished by using the present invention to deliver to the treatment area liquids possessing properties known and/or believed to promote the desired processes.
  • a liquid Once a liquid has been chosen, it is loaded into a liquid supply, if present, or the channel within the ultrasound horn. If a liquid supply is utilized, it may be a syringe, a pump, a reservoir with a gravity feed, a pipette, and/or similar devices capable of dispensing a fluid into the channel of the ultrasound horn.
  • a liquid supply capable of delivering a set and/or predetermined amount of liquid or otherwise capable of indicating or monitoring the amount of liquid delivered allows the user of the present invention to monitor and/or dose the amount of liquid delivered.
  • the liquid supply may be coupled to the ultrasound horn by a flexible hose. Dampening, preventing, and/or lessening the transmission of vibrations from horn to the liquid supply, a flexible hose prevents needles and/or delicate tips of the liquid supply from breaking and/or shearing during operation.
  • an accessible treatment area is one comprising a naturally occurring or created external orifice and/or externally accessible orifice leading into it. If the orifice leading into the treatment area comprises a sore or wound created as a result of the malady to be treated, it is considered a naturally occurring orifice. If the treatment area is inaccessible, an orifice should be created.
  • the creation of secondary orifices allows for the delivery of the chosen liquid from multiple sites into the treatment area. Delivering liquid from multiple orifices may provide a more uniform delivery of the chosen liquid into the treatment area.
  • secondary orifices may provide a point of egress for the delivered liquid enabling the drainage of the delivered liquid and/or fluids within the treatment area, thereby allowing for the evacuation of liberated undesirable elements from the treatment area.
  • the orifice leading into the treatment area may be reinforced by the implantation of cannula into the orifice, as to prevent closure of the orifice.. [0017] Having chosen an appropriate liquid, prepared the liquid supply, and, if necessary, the orifice leading into the treatment area, the user of the present invention then chooses an appropriate dampening grommet. Selecting an appropriate grommet requires consideration of the orifice extending into the treatment area.
  • the distal end of the grommet chosen may posses an outer perimeter sufficiently small as to allow at least a portion of the grommet to be comfortably inserted into the orifice.
  • the outer perimeter of chosen grommet's distal end could be sufficiently large as to allow the grommet to encompass the orifice when pressed against the patient's body.
  • Incorporation of a second channel within the grommet allows for the drainage of the delivered liquid and/or fluids from the treatment area; enabling the evacuation of liberated undesirable elements from the treatment area.
  • the selection of the grommet may also occur before or simultaneously with the selection of the appropriate liquid.
  • At least a portion of the grommet must be capable of dampening, lessening, and/or preventing the transmission of vibrations from the horn to patient and/or orifice. Dampening, lessening, and/or preventing the transmission of vibrations, the dampening grommet prevents and/or lessens the occurrence of injuries to the patient, such as, but not limited to, ultrasonic burns and/or tissue tearing.
  • a seal is formed between the grommet and an orifice leading into the treatment area.
  • the transducer is then activated. If a liquid supply is being utilized, the liquid chosen is delivered into the channel of the ultrasound horn. As the liquid passes through the channel, the liquid becomes accelerated by ultrasonic energy and is ejected from the distal end of the grommet, into the treatment area, as a higher velocity liquid stream. If a liquid supply is not being used, the chosen liquid is then accelerated and expelled from the channel within the horn by the ultrasonic energy emanating from the horn into the channel and is injected into the treatment area.
  • Figure 1 depicts a cross sectional view of an embodiment of the ultrasonic liquid delivery device of the present invention.
  • Figure 2 depicts an exploded view of an embodiment of the liquid delivery device of the present invention.
  • Figure 3 is an illustration of alternative means of attaching the dampening grommet to an ultrasound horn.
  • Figure 4 depicts exemplar configurations of dampening grommets for use with the ultrasonic liquid delivery device of the present invention.
  • Figure 5 contains a flow chart depicting a method of treating maladies within various treatment areas with the present invention.
  • Figure 6 is an illustration of the treatment of bone marrow with an embodiment of the liquid delivery device of the present invention.
  • FIG. 1 Depicted in Figure 1 is a cross sectional view of one embodiment of the ultrasonic liquid delivery device.
  • the liquid delivery device comprises an ultrasound transducer 101, an ultrasound horn 102 attached to the distal end 103 of said transducer 101, a channel 104 running at least partial through said horn 102, and a dampening grommet 105 attached to the distal end 106 of said horn 102.
  • the transducer 101 contains a proximal end 107 including a proximal surface 108. Opposite its proximal end 107, transducer 101 has a distal end 103 including a distal surface 109.
  • the horn 102 contains a proximal end 111, including a proximal surface 112, attached to the distal end 103 of transducer 101. Opposite its proximal end 111, horn 102 has a distal end 106 including a distal surface 113. Extending between the distal end 106 and proximal end 111 of horn 102 is a radial surface 114.
  • the dampening grommet 105 contains a proximal end 115 attached to the distal end 106 of horn 102.
  • grommet 105 Opposite its proximal end 115, grommet 105 has a distal end 116. Extending from the proximal end 115 to the distal end 116 of grommet 105 is a channel 117, which is in communication with channel 104 within horn 102.
  • Channel 104 contains a proximal end 118 originating in radial surface 114 of horn 102, and a distal end 119 opening within distal end 103 of horn 102.
  • the liquid delivery device may further comprise at least one liquid supply 120 in communication with the proximal end 118 of channel 104. As depicted, channel 104 may begin within radial surface 114 at or near the proximal 111 end of horn 102.
  • channel 104 may also run through at least a portion transducer 101.
  • channel 104 could be thought of two channels in communication with one another.
  • the first channel would be a channel originating in a surface of transducer 101, other than the distal surface 109, and extending at least partially through transducer 101 before opening into the second channel.
  • the second channel would be a channel originating within proximal surface 109 of horn 102 and extending through horn 102 before opening at the distal end 106 of horn 102.
  • the liquid supply depicted in Figure 1 is a typical syringe.
  • liquid supplies capable of dispensing a fluid into channel 104 may be similarly effective including, but not limited to, a pump, a reservoir with a gravity feed, and/or a pipette.
  • the liquid delivery device of the present invention may further comprise a flexible hose 121 coupling liquid supply 120 to channel 104, as to prevent breaking and/or shearing of delicate tips and/or needles of the liquid supply chosen.
  • FIG. 2 depicts an exploded view of the embodiment of the liquid delivery device depicted in Figure 1.
  • ultrasound horn 102 may be attached to transducer 101 by mechanical means.
  • the mechanical means depicted comprise a threaded protrusion 201 on the proximal end 111 of the horn 102 with a matching threaded recess 202 in the distal end 103 of transducer 101.
  • Other mechanical means may be used to attach horn 102 to transducer 101.
  • horn 102 and transducer 101 may be formed as a solid piece or constructed from two separate pieces permanently attached by, but not limited to, wielding.
  • horn 102 and transducer 101 may be permanently or temporarily attached by adhesives.
  • the means chosen to attach horn 102 to transducer 101 must allow for the transmission of vibrations generated in transducer 101 to horn 102 and prevent separation of horn 102 from transducer 101 during operation. Elevated ridge 203 at the distal end 106 of horn 102 fits into a recess (not visible) within the inside surface of dampening grommet 105. In the alternative, the distal end 106 of horn 102 may contain multiple elevated ridges 203. [0030] Other mechanical means, such as, but not limited to, a corresponding threaded protrusion and recess, may be used to attach dampening grommet 105 to horn 102, as depicted in Figure 3A and 3B.
  • a threaded protrusion 301 placed at the distal end of horn 102 is received by a threaded portion 302 within channel 117 and at the proximal end 115 of grommet 105.
  • FIG 3B Depicted in Figure 3B is an alternative embodiment in which threaded protrusion 303 at the proximal end 115 of grommet 105 is received by threaded recess 304 at the distal end 106 of horn 102.
  • the threaded protrusions 301 and 303 may comprise channels 305 and 306, respectively, running through them.
  • the threaded recess 304 may be continuous with channel 104 within the ultrasound horn 102.
  • dampening grommet 105 may be attached to ultrasound horn 102 by adhesives. Other means of attaching grommet 105 to horn 102 may be utilized, provided the means chosen prevents the separation of horn 102 from grommet 105 during operation.
  • port 122 located at the proximal end 118 of a channel 104 is a point of attachment for flexible hose 121.
  • hose 121 is depicted as a raised protrusion
  • other means of attaching hose 121 to a channel 104 running through horn 102 such as, but not limited, a recess into which hose 121 may be inserted and/or adhesives, may be equally effective, provided they prevent the separation of hose 121 from the channel 104 during operation.
  • a valve may be placed between the liquid supply and the channel.
  • a valve may be placed at or near the distal end of the channel and/or within the dampening grommet.
  • Ultrasound horn 102 emits into channel 104 within it ultrasonic energy when induced to vibrate by transducer 101 at a frequency between approximately 15 kilohertz and approximately 40 megahertz.
  • the amplitude of the induced ultrasonic vibrations should be approximately at least 1 micron.
  • the preferred low frequency range of the induced ultrasonic vibrations is approximately 15 kilohertz to approximately 200 kilohertz, with a recommended frequency of approximately 20 kilohertz to approximately 60 kilohertz.
  • the preferred low frequency amplitude ranges from approximately 15 microns to approximately 250 microns, with a recommended amplitude of approximately 50 microns.
  • the preferred high frequency range of the induced ultrasonic vibrations is approximately 1 megahertz to approximately 20 megahertz, with a recommended frequency of approximately 1 megahertz to approximately 2 megahertz.
  • the preferred high frequency amplitude ranges from approximately 1 micron to approximately 10 microns, with a recommended amplitude of approximately 5 microns.
  • the ultrasound transducer depicted in Figure 1 and 2 as element 101, may be driven by a generator, which provides the power and signal that drives the transducer.
  • the generator may be a separate unit and/or integral with the transducer.
  • the generator may be powered by an external power supply, such as, but not limited, a traditional wall outlet.
  • the generator may also have an internal power supply, such as, but not limited to, a battery.
  • the distal end of the dampening grommet should be sized to fit within and form a relative seal against the orifice leading into the treatment area.
  • the distal end of the dampening may be sized as to encompass the orifice leading into the treatment area and form a seal against the patient's body.
  • the dampening grommet should be constructed and/or configured as to dampen, prevent, and/or lessen the transmission of vibrations from the ultrasound horn to the patient's body (hereafter referred to as "blocking the transmission of vibrations").
  • Blocking the transmission of vibrations may be achieved by constructing at least a portion the dampening grommet from rubber, plastic, silicon, and/or other compounds capable of absorbing, preventing, lessening, and/or dampening the transmission vibrations (hereafter referred to as "dampening properties").
  • the portion of the dampening grommet constructed from compounds possessing dampening properties should be positioned as to separate portions the grommet not constructed from such compounds.
  • the portion of the dampening grommet constructed from a compound possessing dampening properties may be at the proximal end of grommet as to block the transmission of vibrations from the ultrasound horn to the distal end of the grommet.
  • the dampening grommet Constructing the distal end of the dampening grommet from a compound possessing dampening properties may also be effective.
  • the dampening grommet may be configured such that at least a portion of it is mechanically capable of blocking the transmission of vibrations from the ultrasound horn to the patient (hereafter referred to as "mechanical dampening properties").
  • Such mechanical configurations may comprise, but are not limited to, a dashpot, a coil spring, a leaf spring and/or any combination thereof. When a configuration with mechanical dampening properties is employed, the use of compounds with dampening properties may not be needed.
  • the dampening grommet When the device is to be inserted through one lumen and/or open cavity of the body as to access an orifice leading into the treatment area, such as, but not limited to, when passing through the vagina to access the uterus, the dampening grommet should be constructed and/or configured as to protect the lumen and/or cavity through which it is passed from vibrations emitted from the ultrasound horn and/or transducer.
  • Figure 4 Depicted in Figure 4 are exemplar configurations of dampening grommets for use with the ultrasonic liquid delivery device of the present invention. Though only a few specific exemplars are depicted, many configurations are possible. Consequently, the configurations depicted in Figure 4 and described in detailed below are meant only to be illustrative and non-limiting.
  • Figure A, B, C, and D depict exemplar configurations of a dampening grommet completely constructed from a compound possessing dampening properties.
  • Figure 4A depicts an external and cross-sectional view of a dampening grommet possessing a needle like configuration.
  • a needle like configuration is ideally suited for delivering liquids into treatment areas accessible through narrow orifices such as, but not limited to, the urethra, a sore and/or wound.
  • the needle like grommet depicted in Figure 4A like all dampening grommets, contains channel 117 running from the proximal end 115 to the distal end 116 of the grommet.
  • Recess 401, located within channel 117 receives a ridge located on the distal end of the ultrasound horn and thereby mechanically secures the grommet to the horn.
  • other means of attaching the horn to the grommet may be equally effective.
  • Figure 4B depicts an external and cross- sectional view of a dampening grommet well suited for liquid delivery into treatment areas accessible by way of an intermediate or large orifice such as, but not limited to, the nostrils, anus, and/or vagina.
  • Figure 4C depicts an external and cross-sectional view of a dampening grommet with a double rounded distal end 116 and a second channel 402 branching off of internal channel 117 and opening at the distal end 116 that is well suited for delivering liquids into the sinuses through both of the patient's nostrils simultaneously.
  • Figure 4D depicts an external and cross-sectional view of a dampening grommet with a rounded configuration further comprising a second channel 403 well suited for douching a treatment area. Unlike channel 117, liquids from the liquid supply are not fed through channel 403. Rather channel 403 serves as a point of evacuation for liquids delivered to and/or fluids within the treatment area. Channel 403 may be connected to a collection reservoir and/or other means capable of collecting and containing spent liquids and/or discharged fluids.
  • Figure 5 contains a flow chart depicting a method of treating maladies within lumens, cavities and/or tissues of the body with the ultrasonic liquid delivery device of the present invention.
  • the method begins by first selecting the appropriate liquid to deliver to the bone marrow.
  • the liquid chosen should provide a therapeutic benefit to the bone marrow such as, but not limited to, dissolving unwanted accretions, killing infectious organisms, arresting the growth of infectious organisms, killing cancerous cells, hindering the growth of cancerous cells, encouraging the growth of healthy cells, cleansing the bone marrow of infectious organisms, cleansing the bone marrow of diseased tissue, cleansing the bone marrow of necrotic tissue, or any combination thereof.
  • the liquid chosen should not harm and/or hinder the growth of healthy tissue any more than necessary to achieve the intended therapeutic benefit.
  • a biopsy of the bone marrow may assist the user of the present of the invention in selecting the appropriate liquid. Culturing the removed bone marrow may allow the user to identify the infectious microbe causing the malady to be treated.
  • a biopsy of the bone marrow may also allow the user of the present invention to identify the particular form of leukemia to be treated. Identifying the infectious microbe and/or particular leukemia present allows the user to select a liquid known and/or believed to be effective in treating the infection and/or leukemia present. Other manners of diagnosis and/or selection of an appropriate liquid are well known to those skilled in the healing arts and may be equally as effective.
  • the creation of multiple orifices enables the user of the present invention to flush and/or wash the bone marrow to be treated. Injecting a liquid into the bone marrow with the present invention forces the injected liquid through the bone marrow and out at least one secondary orifice present. Flushing and/or washing the bone marrow may be advantageous when the goal of the treatment is to remove necrotic tissue, cleanse the bone marrow of infectious organisms, cleanse the bone marrow of diseased tissue, removal undesirable elements from the bone marrow, and/or any combination thereof. Orifices may be positioned at any position throughout the bone so long as they provide access to the bone marrow being treated.
  • orifices already present and/or created may be reinforced by implanting a cannula into the orifice. Implantation of a cannula into the orifice helps to prevent wound closure during the interval between successive treatments. Ideally, implanted cannulae should extend into the bone marrow. Once all orifices have been created and cannulae inserted, if any, the present invention is completely assembled and prepared for operation, as depicted in Box 5, if not already done so.
  • Assembling the present invention comprises the steps selecting and attaching an appropriate dampening grommet to the distal end of the ultrasound horn, filling the channel or channels within the ultrasound horn with the chosen liquid, or if a fluid supply is utilized filling a fluid supply with the chosen liquid and attaching said fluid supply to a channel running through the ultrasound horn, connecting said horn to an ultrasound transducer, connecting said transducer to a generator, and connecting said generator to a power supply.
  • Forming the seal may be done by inserting the grommet into the orifice, or cannula if present, such that a seal forms between the outer sides of the grommet and the inner sides of the orifice or cannula.
  • pressing the dampening grommet against a region of the patient's skin encompassing said orifice, or cannula if present may also be done to form a seal between the base of the dampening grommet and the orifice or cannula.
  • forming a seal between the dampening grommet and an orifice may be accomplished by sliding the grommet down the cannulla such that a seal forms between the inner sides of the grommet and the outer sides of the cannula.
  • the ultrasound transducer is then activated, as depicted by Box 7. If a liquid supply is being utilized, following the activation of the ultrasound transducer the chosen liquid is dispensed into a channel within the ultrasound horn, as depicted in Box 8. Following the activation of the ultrasound transducer the chosen liquid is then delivered to the bone marrow for at least approximately five seconds, as depicted by Box 9.
  • the orifices or cannulae should then be cleaned and covered, as depicted in Box 12. Methods of cleaning and covering such orifices and/or cannulae are well known to those skilled in the healing arts.
  • the ultrasound liquid delivery device of the present invention should then be disassembled, as depicted in Box 13. Disposable portions of the present invention, which may comprise the dampening grommet, flexible hose, and/or fluid supply, should be disposed of, as depicted in Box 14. The remaining portions of the device should be cleaned and sterilized, as depicted in Box 15. Methods of cleaning and sterilizing such elements are well known to those skilled in the healing arts.
  • the procedure depicted in Figure 5 should be repeated daily for approximately 10 days, at least.
  • any cannulae inserted should be removed.
  • the sequence of steps described above and depicted in Figure 5 is merely a suggested sequence. Other combinations and/or sequences of the enumerated steps may be equally effective and are within the scope of the present invention. It should also be noted that the above procedure is applicable for treating lumens, cavities and tissues, other than bone marrow, of the body.
  • Depicted in Figure 6 is an illustration of the treatment of bone marrow with an embodiment of the liquid delivery device of the present invention.
  • Grommet 105 is inserted into a cannula 601, extending from the surface of the patient's skin 602 to the bone marrow 603. Alternatively grommet 105 may be inserted into an orifice extending into the bone marrow 603. Cannula 604 is an optional additional cannula extending into the bone marrow which may serve as a point of egress for fluids within bone marrow and/or liquid delivered to the bone marrow. Cannula 604 may also serve as an additional orifice for liquid delivery. [0044] Although specific embodiments and methods of use have been illustrated and described herein, it will be appreciated by those of ordinary skill in the art that any arrangement that is calculated to achieve the same purpose may be substituted for the specific embodiments and methods shown.
  • the disclosed ultrasound liquid delivery device and methods of using ultrasonic energy enable liquid delivery deep into lumens, cavities, and tissues of the body as to treat maladies therein.

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Abstract

La présente invention concerne un dispositif ultrasonique d'administration de liquides et des procédés d'utilisation de l'énergie ultrasonique permettant d'administrer profondément des liquides dans des lumières, des cavités et des tissus de l'organisme. Les liquides présents dans le dispositif sont soumis à une énergie ultrasonique qui provoque une accélération de la vitesse du flux liquide et conduit à un écoulement du liquide à vitesse supérieure et basse pression.
PCT/US2007/079552 2006-09-29 2007-09-26 Dispositif ultrasonique d'administration de liquides et procédés d'utilisation de l'énergie ultrasonique pour administrer des liquides dans le corps Ceased WO2008042669A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009530577A JP2010509944A (ja) 2006-09-29 2007-09-26 超音波流体送達装置、及び超音波エネルギを用いて流体を身体に送達する方法
AU2007304952A AU2007304952A1 (en) 2006-09-29 2007-09-26 Ultrasound liquid delivery device and methods of using ultrasonic energy to deliver liquids into the body
EP07815003A EP2068809A1 (fr) 2006-09-29 2007-09-26 Dispositif ultrasonique d'administration de liquides et procédés d'utilisation de l'énergie ultrasonique pour administrer des liquides dans le corps

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US11/536,911 2006-09-29
US11/536,911 US20080082039A1 (en) 2006-09-29 2006-09-29 Ultrasound Liquid Delivery Device
US11/536,928 2006-09-29
US11/536,928 US8050752B2 (en) 2006-09-29 2006-09-29 Method of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid

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WO2008042669A1 true WO2008042669A1 (fr) 2008-04-10
WO2008042669A8 WO2008042669A8 (fr) 2009-01-15

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EP (1) EP2068809A1 (fr)
JP (1) JP2010509944A (fr)
KR (1) KR20090077930A (fr)
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WO2013041700A1 (fr) * 2011-09-22 2013-03-28 Commissariat à l'énergie atomique et aux énergies alternatives Pompe d'injection d'un fluide, et notamment micropompe utilisable pour delivrer une dose determinee
US11185626B2 (en) 2015-04-08 2021-11-30 Massachusetts Institute Of Technology Systems, apparatus, and methods for administering a substance

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US4961018A (en) * 1989-08-11 1990-10-02 Wayne/Scott Fetzer Company Enclosed pump motor and wiring thereof
WO1997017933A1 (fr) * 1995-11-15 1997-05-22 Aeropag Usa, Inc. Procede de pulverisation sur une surface, en utilisant des ultrasons
US20050229926A1 (en) * 2004-04-20 2005-10-20 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US20060025716A1 (en) * 2000-10-06 2006-02-02 Eilaz Babaev Nozzle for ultrasound wound treatment
US20060173385A1 (en) * 2003-06-04 2006-08-03 Lars Lidgren Ultrasound probe having a central opening

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4961018A (en) * 1989-08-11 1990-10-02 Wayne/Scott Fetzer Company Enclosed pump motor and wiring thereof
WO1997017933A1 (fr) * 1995-11-15 1997-05-22 Aeropag Usa, Inc. Procede de pulverisation sur une surface, en utilisant des ultrasons
US20060025716A1 (en) * 2000-10-06 2006-02-02 Eilaz Babaev Nozzle for ultrasound wound treatment
US20060173385A1 (en) * 2003-06-04 2006-08-03 Lars Lidgren Ultrasound probe having a central opening
US20050229926A1 (en) * 2004-04-20 2005-10-20 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013041700A1 (fr) * 2011-09-22 2013-03-28 Commissariat à l'énergie atomique et aux énergies alternatives Pompe d'injection d'un fluide, et notamment micropompe utilisable pour delivrer une dose determinee
FR2980535A1 (fr) * 2011-09-22 2013-03-29 Commissariat Energie Atomique Pompe d'injection d'un fluide, et notamment micropompe utilisable pour delivrer une dose determinee
US11185626B2 (en) 2015-04-08 2021-11-30 Massachusetts Institute Of Technology Systems, apparatus, and methods for administering a substance

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AU2007304952A1 (en) 2008-04-10
JP2010509944A (ja) 2010-04-02
WO2008042669A8 (fr) 2009-01-15
KR20090077930A (ko) 2009-07-16
EP2068809A1 (fr) 2009-06-17

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