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WO2007139948A3 - Imidazoazepinone compounds - Google Patents

Imidazoazepinone compounds Download PDF

Info

Publication number
WO2007139948A3
WO2007139948A3 PCT/US2007/012516 US2007012516W WO2007139948A3 WO 2007139948 A3 WO2007139948 A3 WO 2007139948A3 US 2007012516 W US2007012516 W US 2007012516W WO 2007139948 A3 WO2007139948 A3 WO 2007139948A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazoazepinone
compounds
formula
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/012516
Other languages
French (fr)
Other versions
WO2007139948A2 (en
Inventor
Mark Spyvee
Boris M Seletsky
Shawn Schiller
Christina J Shaffer
Jia Liu
Xiang-Yi Li
Qian Chen
Roch Boivin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of WO2007139948A2 publication Critical patent/WO2007139948A2/en
Publication of WO2007139948A3 publication Critical patent/WO2007139948A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an enantiomerically pure compound of formula I: along with pharmaceutical formulations containing the same and methods of use thereof the treatment of autoimmune disease.
PCT/US2007/012516 2006-05-26 2007-05-25 Imidazoazepinone compounds Ceased WO2007139948A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US80877006P 2006-05-26 2006-05-26
US80890606P 2006-05-26 2006-05-26
US60/808,906 2006-05-26
US60/808,770 2006-05-26
US81561706P 2006-06-22 2006-06-22
US60/815,617 2006-06-22

Publications (2)

Publication Number Publication Date
WO2007139948A2 WO2007139948A2 (en) 2007-12-06
WO2007139948A3 true WO2007139948A3 (en) 2008-01-24

Family

ID=38649936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/012516 Ceased WO2007139948A2 (en) 2006-05-26 2007-05-25 Imidazoazepinone compounds

Country Status (1)

Country Link
WO (1) WO2007139948A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064431A1 (en) * 2007-11-15 2009-05-22 Eisai E & D Management Co., Ltd. Methods of use
WO2011011494A1 (en) * 2009-07-21 2011-01-27 Eisai R&D Management Co., Ltd. Imidazoazepinone compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0385489A1 (en) * 1989-03-03 1990-09-05 Eisai Co., Ltd. Azacyclooctadiene compound and pharmaceutical use
EP1619193A1 (en) * 2003-04-18 2006-01-25 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2006128143A2 (en) * 2005-05-27 2006-11-30 Eisai Co., Ltd. Hydantoin compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0385489A1 (en) * 1989-03-03 1990-09-05 Eisai Co., Ltd. Azacyclooctadiene compound and pharmaceutical use
EP1619193A1 (en) * 2003-04-18 2006-01-25 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2006128143A2 (en) * 2005-05-27 2006-11-30 Eisai Co., Ltd. Hydantoin compounds

Also Published As

Publication number Publication date
WO2007139948A2 (en) 2007-12-06

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