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WO2007136936A3 - Dermis-derived cells for tissue engineering applications - Google Patents

Dermis-derived cells for tissue engineering applications Download PDF

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Publication number
WO2007136936A3
WO2007136936A3 PCT/US2007/066085 US2007066085W WO2007136936A3 WO 2007136936 A3 WO2007136936 A3 WO 2007136936A3 US 2007066085 W US2007066085 W US 2007066085W WO 2007136936 A3 WO2007136936 A3 WO 2007136936A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermis
cells
tissue engineering
derived cells
engineering applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/066085
Other languages
French (fr)
Other versions
WO2007136936A2 (en
Inventor
Kyriacos A Athanasiou
Ying Deng
Jerry Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Priority to EP07760205A priority Critical patent/EP2007875A4/en
Priority to CA002648648A priority patent/CA2648648A1/en
Priority to AU2007254048A priority patent/AU2007254048A1/en
Publication of WO2007136936A2 publication Critical patent/WO2007136936A2/en
Anticipated expiration legal-status Critical
Priority to US12/246,367 priority patent/US20090142307A1/en
Priority to US12/246,306 priority patent/US20090136559A1/en
Priority to US12/246,320 priority patent/US8637065B2/en
Publication of WO2007136936A3 publication Critical patent/WO2007136936A3/en
Priority to US13/029,325 priority patent/US20110212894A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Improved methods for tissue engineering are provided. More particularly, methods are provided for inducing differentiation of dermis-derived cells to serve as a source of chondrocytes and associated methods of use in forming tissue engineered constructs. One example of a method is a method for inducing differentiation of cells into chondrocytes comprising providing aggrecan sensitive isolated dermis cells and seeding the cells onto an aggrecan coated surface.
PCT/US2007/066085 2004-07-09 2007-04-05 Dermis-derived cells for tissue engineering applications Ceased WO2007136936A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP07760205A EP2007875A4 (en) 2006-04-05 2007-04-05 CELLS FROM LEATHER SKIN FOR TISSUE BREEDING
CA002648648A CA2648648A1 (en) 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications
AU2007254048A AU2007254048A1 (en) 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications
US12/246,367 US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,306 US20090136559A1 (en) 2004-07-09 2008-10-06 Chondrocyte Differentiation from Human Embryonic Stem Cells and Their Use in Tissue Engineering
US12/246,320 US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications
US13/029,325 US20110212894A1 (en) 2004-07-09 2011-02-17 Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78985506P 2006-04-05 2006-04-05
US78985306P 2006-04-05 2006-04-05
US78985106P 2006-04-05 2006-04-05
US60/789,853 2006-04-05
US60/789,855 2006-04-05
US60/789,851 2006-04-05

Related Parent Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2005/024269 Continuation-In-Part WO2006017176A2 (en) 2004-07-09 2005-07-08 Scaffoldless constructs for tissue engineering of articular cartilage
PCT/US2007/066092 Continuation-In-Part WO2007115337A2 (en) 2004-07-09 2007-04-05 Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
US12/246,367 Continuation-In-Part US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,320 Continuation-In-Part US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications
US57179010A Continuation-In-Part 2004-07-09 2010-08-23

Related Child Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2007/066089 Continuation-In-Part WO2007115336A2 (en) 2004-07-09 2007-04-05 A shape-based approach for scaffoldless tissue engineering
US12/246,367 Continuation-In-Part US20090142307A1 (en) 2004-07-09 2008-10-06 Shape-Based Approach for Scaffoldless Tissue Engineering
US12/246,306 Continuation-In-Part US20090136559A1 (en) 2004-07-09 2008-10-06 Chondrocyte Differentiation from Human Embryonic Stem Cells and Their Use in Tissue Engineering
US12/246,320 Continuation-In-Part US8637065B2 (en) 2004-07-09 2008-10-06 Dermis-derived cells for tissue engineering applications

Publications (2)

Publication Number Publication Date
WO2007136936A2 WO2007136936A2 (en) 2007-11-29
WO2007136936A3 true WO2007136936A3 (en) 2008-10-23

Family

ID=38564326

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2007/066092 Ceased WO2007115337A2 (en) 2004-07-09 2007-04-05 Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
PCT/US2007/066085 Ceased WO2007136936A2 (en) 2004-07-09 2007-04-05 Dermis-derived cells for tissue engineering applications
PCT/US2007/066089 Ceased WO2007115336A2 (en) 2004-07-09 2007-04-05 A shape-based approach for scaffoldless tissue engineering

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/066092 Ceased WO2007115337A2 (en) 2004-07-09 2007-04-05 Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/066089 Ceased WO2007115336A2 (en) 2004-07-09 2007-04-05 A shape-based approach for scaffoldless tissue engineering

Country Status (4)

Country Link
EP (3) EP2007881A4 (en)
AU (3) AU2007234366A1 (en)
CA (3) CA2648332A1 (en)
WO (3) WO2007115337A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7824711B2 (en) 2003-12-11 2010-11-02 Isto Technologies, Inc. Particulate cartilage system
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2010022074A1 (en) * 2008-08-18 2010-02-25 William Marsh Rice University A decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc IMPLANTS AND METHODS FOR THE TREATMENT, REPLACEMENT AND TREATMENT OF JOINT DISEASES
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
EP2254508A4 (en) * 2008-03-03 2012-03-28 Univ Rice William M METHODS OF FABRICATION OF ENHANCED CARTILAGE OF TISSUE ENGINEERING
US9303245B2 (en) * 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
JP5624981B2 (en) 2008-06-24 2014-11-12 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ Self-assembling multicellular body and method for producing a three-dimensional biological structure using the multicellular body
ES2778750T3 (en) * 2009-07-16 2020-08-11 Lineage Cell Therapeutics Inc Methods and compositions for in vitro and in vivo chondrogenesis
KR20160125530A (en) 2010-10-21 2016-10-31 오가노보, 인크. Devices, systems, and methods for the fabrication of tissue
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
BR112014005746A2 (en) 2011-09-12 2017-03-28 Organovo Inc engineered fabrics for in vitro research use, arrangement thereof, and methods of manufacturing the same
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
US20150037445A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
EP3808838B1 (en) 2014-04-04 2024-04-10 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
US9670443B2 (en) 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
MA40495A (en) 2014-10-06 2016-04-14 Organovo Inc Engineered renal tissues, arrays thereof, and methods of making the same
US11529436B2 (en) 2014-11-05 2022-12-20 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
AU2016352873B2 (en) 2015-11-09 2023-01-05 Organovo, Inc. Improved methods for tissue fabrication

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WO1997017038A1 (en) * 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions

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CA2468335C (en) * 2001-12-07 2014-07-08 Geron Corporation Chondrocyte precursors derived from human embryonic stem cells
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
WO2003084385A2 (en) * 2002-04-02 2003-10-16 William Marsh Rice University Redifferentiated cells for repairing cartilage defects
US20040082063A1 (en) * 2002-10-18 2004-04-29 Reliance Life Sciences Pvt. Ltd. Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture
WO2006017176A2 (en) * 2004-07-09 2006-02-16 William Marsh Rice University Scaffoldless constructs for tissue engineering of articular cartilage

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WO1997017038A1 (en) * 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DESSAU ET AL.: "Extracellular Matrix Formation by Chondrocytes in Monolayer culture", THE JOURNAL OF CELL BIOLOGY, vol. 90, July 1981 (1981-07-01), pages 78 - 83, XP002995913 *
FRENCH ET AL.: "Chondrogenic Differentiation of Adult Dermal Fibroblasts", ANNALS OF BIOMEDICAL ENGINEERING, vol. 32, no. 1, January 2004 (2004-01-01), pages 50 - 56, XP019272765 *
KISIDAY ET AL.: "Self assembly peptide hydrogel fosters chondrocyte extra cellualr matrix production and cell division for cartilage tissue repair", PNAS, vol. 99, no. 15, 23 July 2002 (2002-07-23), pages 9996 - 10001, XP008130663 *
See also references of EP2007875A4 *
SWEIGART ET AL.: "Fibrochondrocytes and their Use in Tissue Engineering of the Meniscus", TOPICS IN TISSUE ENGINEERING, vol. CHAPTER 1, 2003, XP008131889 *

Also Published As

Publication number Publication date
WO2007115337A3 (en) 2008-07-03
EP2007881A2 (en) 2008-12-31
EP2007875A2 (en) 2008-12-31
CA2648648A1 (en) 2007-11-29
CA2648332A1 (en) 2007-10-11
CA2648327A1 (en) 2007-10-11
WO2007115336A3 (en) 2008-05-22
AU2007234366A1 (en) 2007-10-11
EP2007312A2 (en) 2008-12-31
AU2007234365A1 (en) 2007-10-11
WO2007115336A2 (en) 2007-10-11
WO2007115337A2 (en) 2007-10-11
EP2007875A4 (en) 2009-12-16
WO2007115337A8 (en) 2007-12-13
EP2007881A4 (en) 2009-07-08
EP2007312A4 (en) 2012-08-22
AU2007254048A1 (en) 2007-11-29
WO2007136936A2 (en) 2007-11-29

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