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WO2007133214A1 - Dispositifs prothétiques de remplacement du noyau discal et de reconstruction de tissus mous - Google Patents

Dispositifs prothétiques de remplacement du noyau discal et de reconstruction de tissus mous Download PDF

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Publication number
WO2007133214A1
WO2007133214A1 PCT/US2006/018987 US2006018987W WO2007133214A1 WO 2007133214 A1 WO2007133214 A1 WO 2007133214A1 US 2006018987 W US2006018987 W US 2006018987W WO 2007133214 A1 WO2007133214 A1 WO 2007133214A1
Authority
WO
WIPO (PCT)
Prior art keywords
pouch
medical device
gellant
kit according
replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/018987
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English (en)
Inventor
Murali Jasty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Priority to PCT/US2006/018987 priority Critical patent/WO2007133214A1/fr
Publication of WO2007133214A1 publication Critical patent/WO2007133214A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/12—Mammary prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00131—Tantalum or Ta-based alloys

Definitions

  • the present invention generally relates to medical devices for prosthetic disc nuclear replacement, soft-tissue replacement, reconstruction or augmentation and methods of implanting the medical devices.
  • the invention also relates to methods of treating mammals by implanting the medical devices.
  • Some of the currently available disc replacement devices contain metallic end- plates and softer polymeric material bearing surfaces between the end-plates. These devices replace the entire disc, including the annulus and the nucleus.
  • the most widely implanted disc to date is the Link SB Charite disc (Waldemar Link GmbH & Co, Hamburg, Germany), which consists of a biconvex ultra high molecular weight polyethylene (UHMWPE) spacer. This core spacer interfaces with two separate end- plates.
  • UHMWPE ultra high molecular weight polyethylene
  • prosthetic nuclear replacement devices replace the nuclear material of the disc with prosthetic materials having similar mechanical properties (such as hydrogels).
  • hydrogels unlike the above devices, the annulus fibrosis is not completely removed.
  • polyvinyl alcohol and polyethylene glycol based hydrogels have been advocated because of their similarities to the nuclear material in load carrying capacity, elastic modulus, and water retaining characteristics.
  • Hubbell (US Pat. No. 6,129,761) describes the use of an injectable hydrogel composition to reconstruct muscle and cartilage tissues, and to repair defects such as reflux and incontinence. Hubbell also disclosed a method for making and implanting a cell-hydrogel suspension into an animal whereas the biocompatible polymer is crosslinked to form a hydrogel matrix. The application of such hydrogen composition is limited to tissue augmentation or use as a replacement material. Ruberti et al. (US Publication Nos. 20040171740 and 20040092653) also describe injectable hydrogels and methods for in situ solidification of poly vinyl alcohol hydrogels.
  • a second fluid is added to the hollow interior to inflate the nucleus.
  • the device contains two chambers.
  • the disadvantage of this device is that two chambers are required to replace the annulus and the nucleus.
  • an artificial annulus cannot replace a biologically active natural annulus containing living tissue with instant blood supply, which instantly can repair and remodel the disc. Therefore, in order to treat a disc degenerative disorder, it is essential to replace only the nuclear material, which does not require instant blood supply and allows the natural annulus to re-grow and repair the disorder.
  • Soft-tissue reconstruction or augmentation such as expansion of ear, nose, lip, and other body parts, has been practiced by primitive cultures for aesthetic or religious purposes.
  • tissue augmentation devices Another known approach for small volume of tissue augmentation involves injection of collagen gels directly into the tissue, however, foreign body reaction to the collagens and difficulties in maintaining the shape of the injected materials are of major concerns. Moreover, leakage of silicone from breast implants and the tissue reactions to the silicone, which lead to considerable morbidity, is another major problem associated with the tissue augmentation devices known in the art.
  • Craniofacial Reconstruction Auricular, nasal and eyelid reconstructions use tissue expansion to expand the skin in the areas. Once adequate skin become available, the cartilage framework is placed into the expanded area and reconstruction is performed.
  • the present invention provides medical devices for prosthetic disc nuclear replacement, soft-tissue reconstruction devices, methods of implanting the devices, and methods of treating mammals with disc degenerative diseases. More specifically, the invention provides compositions and methods for implanting a deflated or empty or a partially filled pouch or device into a mammal by a minimally invasive surgical procedure. Subsequently, the implanted device is inflated by injecting a suitable gellant or a combination of gellants, and to allow the device to solidify and form a medical device of desired size and shape.
  • the invention also provides medical devices for intervertebral disc replacement, soft-tissue reconstruction, wound care, cartilage replacement, joint replacement, implantation as a surgical barrier or a gastrointestinal device, a cosmetic and reconstructive operation, including the expansion of soft tissues, replacement for the spinal disc, augmentation of breast or muscle enlargement, chin, cheek, ear and nose, as an implant in reinforcing the sphincter muscles of the esophagus, bladder, and wherever tissue reinforcement or augmentation is needed.
  • the invention provides methods of implanting medical devices for replacing, reconstructing, or augmenting a soft-tissue in a mammal, wherein the method comprises: a) implanting a flexible empty or partially filled pouch into a selected site of the mammal; and b) injecting at least one type of gellant into the pouch, wherein the gellant solidifies within the pouch, thereby implanting the medical device.
  • the gellant further comprising materials selected from the group consisting carbon fiber, metal fiber, collagen fiber, proteoglycan, growth factor and antibiotic.
  • the pouch surface comprises polytetrafluoroethylene (PTFE) (for example, GortexTM), vinyl polymers, polyethylene such as UHMWPE, polyacrylonitrile (PAN) (for example, KevlarTM), polysulfone, silastic, polyester (for example, polyethylene tetraphthalate such as DacronTM), polyamide, nylon, valour, polyurethane, polyolefins, polyhydrocarbons, or combinations thereof.
  • PTFE polytetrafluoroethylene
  • VAN polyacrylonitrile
  • KevlarTM KevlarTM
  • polysulfone silastic
  • polyester for example, polyethylene tetraphthalate such as DacronTM
  • the pouch surface comprises polymer, polymer blends, copolymers, or combinations thereof.
  • the pouch surface comprises polyvinyl alcohol (PVA), polyvinyl chloride (PVC), hydroxyethyl methacrylate, polyethylene glycol (PEG), poly ethylene oxide (PEO), polyvinyl pyrrolidone (PVP), poly-N-isopropyl acrylamide (PNIAAm), polymethyl methacrylate, polyethyl methacrylate, polysulfone, polyamide, polylactic acid, silicone, silastic, polyfumarate, polyetheretherketone, polybutyl methacrylate and polyurethane, polyamines, fibrin, hylauronic acid, chitin, albumin, collagen, chondroitin sulfate, or combinations thereof as well as other hydrocarbons.
  • PVA polyvinyl alcohol
  • PVC polyvinyl chloride
  • PEG polyethylene glycol
  • PEO poly ethylene oxide
  • PVP polyvinyl pyrrolidone
  • PNIAAm poly-N-isopropyl acryl
  • Figure 6 shows porous metal end-plates (6) placed on top and bottom of a deflated and subsequently inflated device.
  • Figure 7 depicts a schematic diagram of repeated injections of gellants into an implanted pouch (4) to provide the implant a gradient of stiffness or other desired physico-chemical or mechanical properties, or to repair a fractured implant (8).
  • the present invention generally relates to medical devices for prosthetic disc nuclear replacement, soft-tissue replacement, reconstruction, augmentation, methods of implanting the devices, and methods of treating and preventing the progression of nuclear disc degenerative disease.
  • Degenerative disease of the disc is one of the most frequently treated spinal disc degenerative conditions.
  • Hardening of the gels preserves the shape of the pouch and thus the shape of the tissue being reconstructed or replaced.
  • the device can be used in a variety of reconstructive procedures, including the expansion of soft tissues, replacement of spinal disc, augmentation of breast, chin, cheek, ear, and nose, as an implant in reinforcing the sphincter muscles of the esophagus, bladder, and wherever tissue reconstruction, reinforcement or augmentation is needed.
  • the filler materials can be any material which can form solid gels after polyemerizing and/or crosslinking, such as fibrin gels, keratin gels, hylauronic acid gels, and the like.
  • Hydrogels used for tissue augmentation are biocompatible, harden with tunable material properties, such as compressive stiffness and viscoelastic behavior, can be made soft and compressible, and elicit little foreign body reaction.
  • the solidified pouches or the medical devices can be flexible, depending on the mechanical properties of the solidified gellant or combination of gellants.
  • Gellants for example, upon injection into a pouch or an implanted pouch, provide the pouch or the medical device a desirable shape, size, and mechanical strength.
  • gellants solidifies indicates that the gellants undergo solidification process inside the pouch or the medical device and provide and maintain the pouch or the medical device a desirable shape, size, and mechanical strength, however, the solidified pouch or the medical device still can be flexible.
  • An implanted gellant-filled solidified pouch maintains a shape memory and can revert back to its original shape or shape that is approximate to the original shape once a deforming force is eliminated.
  • the disc height should be maintained using a suitable material, which is capable of carrying heavy loads and providing shock absorption (preferably by hydrostatic pressure, loads of as much as 1000 Newtons can be produced on the disc space in activities such as bending, which requires a compressive strength of the disc of at least 4MN/square meter); and
  • the above measures are taken by replacing the nuclear gel with a load carrying material, which is capable of carrying heavy loads under hydrostatic pressure, as described above, and allows regeneration of the annulus fibrosis by scar tissues, and maintains the height of the disc space. The procedure is completed with minimally invasive surgical techniques and can be done repeatedly in necessary.
  • the invention provides medical devices to replace the nuclear material with a solid or semisolid polymer, which is contained within a pouch and allows the expansion of the pouch to close the opening in the annulus and seal.
  • the pouch can be of any shape or mixtures thereof, for example, a cylindrical shape, a spherical shape, a ellipsoidal shape, a trapezoidal shape, a rhomboid shape and/or irregular shapes, or the shape of a body cavity or a nuclear space. Since the instant device expands within the confines of the annulus, the potential of the nucleus to extrude though the annulus opening is substantially low.
  • a deflated pouch or a medical device is inserted into a nuclear space with a minimally invasive technique, since it occupies a very little space in its collapsed, deflated, or non expanded state.
  • the consistency of a pouch is comparable to the consistency of a fabric, a cloth, or a membrane.
  • Pouch surface materials can be prepared under suitable conditions to obtain a desirable consistency.
  • a suitable porous surface of the pouch made of materials such as vinyl polymers, polyethylene such as UHMWPE, or nylon can allow the annulus to re-grow into the pouch surface and can provide long term anchorage and seal. This also can place the nuclear replacement material under hydrostatic loading, thereby improving the load carrying function of the nuclear replacement material.
  • compositions such as antibiotics and/or chemotherapeutic agents, and biologic agents such as tissue growth factors, transforming growth factors, platelet derived growth factors, fibroblast growth factors, angiogenic factors and the like can be incorporated readily into the gels, which provides additional benefits for enhancing tissue growth and delivery of antibiotics.
  • the pouches are preferably made in a sealed position, however, also can be made by heat sealing a pouch surface or the sheet materials along the seams. Sealing of a pouch is not necessary following the injection of the gellant(s), because the solidified gel is not likely to leak out after the pouch.
  • gellant used in loading or inflating a pouch or a medical device can be hydrogels, polymer, polymer blends, or copolymers of polyvinyl alcohol (PVA), polyethylene glycol (PEG), poly ethylene oxide (PEO), polyvinyl pyrrolidone (PVP), poly-N-isopropyl acrylamide (PNIAAm), polyfumarate, polyetheretherketone, polybutyl methacrylate and polyurethane, polyolefins, polyhydrocarbons, polyamines, fibrin, hylauronic acid, chitin, albumin, collagen, or chondroitin sulfate, dextran sulfate, dermatin sulfate, and the like.
  • PVA polyvinyl alcohol
  • PEG polyethylene glycol
  • PEO poly ethylene oxide
  • PVP polyvinyl pyrrolidone
  • PNIAAm poly-N-isopropyl acrylamide
  • polyfumarate poly
  • this disclosure provides gellants comprising polymer, polymer blends, copolymers, polyolefins, polyhydrocarbons, or combinations thereof.
  • polyvinyl alcohol PVA
  • polyethylene glycol PEG
  • poly ethylene oxide PEO
  • polyvinyl pyrrolidone PVP
  • poly-N-isopropyl acrylamide PNIAAm
  • polymethyl methacrylate polyethyl methacrylate, polysulfone, polyamide, polylactic acid, silicone, polyfumarate, polyetheretherketone, polybutyl methacrylate and polyurethane
  • polyamines fibrin, hylauronic acid, chitin, albumin, collagen, chondroitin sulfate, or combinations thereof.
  • the gellants include carbon fibers, metal fibers, collagen fibers, proteoglycans, growth factors, and antibiotics.
  • KevlarTM polysulfone, silastic, polyester (for example, polyethylene tetraphthalate such as DacronTM), polyamide, nylon, valour, and polyurethane, which can be used to make pouch surface, fabric, film, or sheet-like materials.
  • polyester for example, polyethylene tetraphthalate such as DacronTM
  • polyamide for example, polyamide, nylon, valour, and polyurethane
  • the above listed gellants also can be used to make pouch surface, fabric, film, or sheet-like materials.
  • the molecular weight of the polyethylene can range from a few thousand to 5 millions depending on the tensile strength required for a specific application.
  • low density linear polyethylene, nylon, or polytetrafluoroethylene (PTFE) for example, GortexTM
  • PTFE polytetrafluoroethylene
  • gelation refers to a process of gel formation or solidification of a matrix or a nuclear material inside a pouch containing at least one gellant.
  • the term “gelation” also refers to the formation of permanent physical cross-links due to the crystallization of the polymer solution, for example, the PVA solution and/or at least one of the gellants.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne des dispositifs médicaux pour le remplacement du noyau discal par prothèse, le remplacement, la reconstruction ou l'augmentation de tissus mous, des procédés d'implantation de ces dispositifs, des procédés de traitement de mammifères atteints de dégénérescence discale, et des kits pour le remplacement de noyau discal et le remplacement, la reconstruction ou l'augmentation de tissus mous. L'invention concerne également un dispositif médical pour le remplacement du disque intervertébral, le traitement des plaies, le remplacement du cartilage, le remplacement de l'articulation, l'implantation en tant que barrière chirurgicale ou dispositif gastro-intestinal, une opération de chirurgie esthétique ou reconstructrice, une opération de chirurgie reconstructrice des oreilles, du menton, des joues ou du nez, ou une augmentation mammaire ou musculaire. Des procédés consistant à implanter un dispositif dégonflé chez un mammifère au cours d'une intervention chirurgicale et à gonfler par la suite le dispositif implanté avec un gélifiant approprié ou une combinaison de gélifiants sont également divulgués.
PCT/US2006/018987 2006-05-17 2006-05-17 Dispositifs prothétiques de remplacement du noyau discal et de reconstruction de tissus mous Ceased WO2007133214A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2006/018987 WO2007133214A1 (fr) 2006-05-17 2006-05-17 Dispositifs prothétiques de remplacement du noyau discal et de reconstruction de tissus mous

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Application Number Priority Date Filing Date Title
PCT/US2006/018987 WO2007133214A1 (fr) 2006-05-17 2006-05-17 Dispositifs prothétiques de remplacement du noyau discal et de reconstruction de tissus mous

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042049A1 (fr) 2008-10-10 2010-04-15 Milux Holding S.A. Composition, procédé et dispositif de stabilisation de dispositifs hydrauliques implantés
US9668875B2 (en) 1999-03-07 2017-06-06 Nuvasive, Inc. Method and apparatus for computerized surgery
CN110368148A (zh) * 2019-08-05 2019-10-25 北京爱康宜诚医疗器材有限公司 柔性人工椎间盘

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US6443988B2 (en) * 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US6733533B1 (en) * 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6443988B2 (en) * 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US6733533B1 (en) * 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9668875B2 (en) 1999-03-07 2017-06-06 Nuvasive, Inc. Method and apparatus for computerized surgery
WO2010042049A1 (fr) 2008-10-10 2010-04-15 Milux Holding S.A. Composition, procédé et dispositif de stabilisation de dispositifs hydrauliques implantés
US9675390B2 (en) 2008-10-10 2017-06-13 Peter Forsell Composition, method and device for stabilizing implanted hydraulic devices
US20170273726A1 (en) * 2008-10-10 2017-09-28 Peter Forsell Composition, method and device for stabilizing implanted hydraulic devices
US10939942B2 (en) * 2008-10-10 2021-03-09 Peter Forsell Composition, method and device for stabilizing implanted hydraulic devices
US20210161570A1 (en) * 2008-10-10 2021-06-03 Peter Forsell Composition, method and device for stabilizing implanted hydraulic devices
CN110368148A (zh) * 2019-08-05 2019-10-25 北京爱康宜诚医疗器材有限公司 柔性人工椎间盘
CN110368148B (zh) * 2019-08-05 2024-05-28 北京爱康宜诚医疗器材有限公司 柔性人工椎间盘

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