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WO2007132184A1 - Dispositif automatique d'aspiration d'échantillons et récipient destiné à être utilisé avec le dispositif - Google Patents

Dispositif automatique d'aspiration d'échantillons et récipient destiné à être utilisé avec le dispositif Download PDF

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Publication number
WO2007132184A1
WO2007132184A1 PCT/GB2007/001711 GB2007001711W WO2007132184A1 WO 2007132184 A1 WO2007132184 A1 WO 2007132184A1 GB 2007001711 W GB2007001711 W GB 2007001711W WO 2007132184 A1 WO2007132184 A1 WO 2007132184A1
Authority
WO
WIPO (PCT)
Prior art keywords
combination
container
automated
tube
centrifuge tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/001711
Other languages
English (en)
Inventor
Richard Banfield Hicks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diasys Europe Ltd
Original Assignee
Diasys Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diasys Europe Ltd filed Critical Diasys Europe Ltd
Publication of WO2007132184A1 publication Critical patent/WO2007132184A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • B01L3/5457—Labware with identification means for laboratory containers for container closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control

Definitions

  • This invention relates to a combination of automated apparatus and a container for use therewith, and more specifically to the combination of automated aspiration apparatus for biological samples and a container moulded from a transparent or translucent plastics material, such as a centrifuge tube.
  • a transparent or translucent plastics material such as a centrifuge tube.
  • Urine and faecal solutions are typically concentrated by centrifugation. The faecal solution will also be filtered to remove debris.
  • the higher density micro-organisms tend to settle at the bottom of the centrifuge tube and are easily removed by aspiration.
  • the aspiration tube orifice must be below the sample surface and at a depth that will ensure sufficient volume of sample can be drawn into the chamber of the transparent slide. If the aspiration tube is positioned too high, air may be drawn into the chamber. If the aspiration tube is positioned too low, the sediment may block the aspirator tube orifice. It is important to note that there are many centrifugal tubes available in the market. The selection of the wrong tube may invalidate the test for the reasons given above.
  • a principal object of this invention is to ensure that the aspiration system can recognise a tube presented to it and only aspirate a sample if the correct tube has been selected.
  • the container being moulded from a transparent or translucent plastics material at least in an area in the region of the mouth being fabricated or treated in such a way as to alter the conductivity, capacitance, magnetic field or light absorption, transmission or reflection or optical characteristics of the plastics material, the automated apparatus including means for detecting the presence of said altered characteristics and for responding to the absence thereof when the container is presented to the apparatus.
  • the arrangement is preferably such that in the absence of said altered characteristics the apparatus is inoperable.
  • the altered characteristics are provided by an area in the region of the mouth which is not smooth and is produced by a roughened, collar region of the mould.
  • the automated apparatus may be an electrically powered semi-automated or automated aspiration system for biological samples and the container may be a centrifuge tube.
  • the detecting means is arranged to enable the aspiration system to function only when presented with a container having said altered characteristics.
  • the plastics material is a polymeric material having titanium dioxide white pigment as an additive.
  • the detecting means is preferably a reflective object sensor containing a diode and a photodarlington, the latter controlling an electrical circuit of the automated apparatus.
  • the container's conductivity, capacitance and magnetic field can be enhanced by the addition of metallic compounds. Although feasible options these compounds may reduce the clarity of the polymer.
  • the addition of dyes or pigments to the natural polymer can change the light transmission, light reflection and light absorption characteristic of the polymer. These changes to the polymer can be detected without substantial loss of light transmission in the visible spectrum.
  • Centrifuge tubes are generally made from natural polymer and have a poor reflection characteristic.
  • the addition of titanium dioxide white pigment in a small proportion to the natural polymer increases the infra red / ultra violet reflectivity such that a light sensor can detect the pigmented polymer but light transmission through the tube is substantially unaffected.
  • the tube 10 is one of a number of tubes of an automated aspiration system of the kind disclosed in the said International Patent Publication WO9324213.
  • a probe 18 extending from the tube 10 is being inserted into a centrifuge tube 11, a handle 12 ensuring that the probe cannot be inserted too deeply into a urine or faecal sample 15 in the centrifuge tube by a collar 13 coming to rest on and closing the open top of the centrifuge tube.
  • an electrically operated pump (not shown) of the aspiration system will suck a proportion of the sample 15 into the chamber of a transparent slide to which the tube 10 is connected so that the sample can be inspected.
  • a mould (not shown) from which the centrifuge tube 11 is made has a roughened surface area corresponding with the mouth 14 of the centrifuge tube.
  • the mouth region 14 of the tube 11 has a roughened texture contrasting with the smooth surfaces of the remainder of the tube.
  • Attached to the collar 13 of the handle 12 is a reflective object sensor 16 containing a diode and a photodarlington of the kind commercially available from Fairchild Semiconductor Corporation. This controls the function of the pump of the aspiration system, through a lead 17, such that the pump will operate only if the sensor 16 detects that the centrifuge tube 11 has the light reflective characteristic imparted to it by the roughened area 14.. If the centrifuge tube 11 lacks this roughened area the aspiration system will not operate.
  • the surfaces of the centrifuge tube 11 are entirely smooth, as is conventional, but a small quantity of titanium dioxide white pigment has been included in the polymer from which the centrifuge tube has been moulded.
  • the sensor 16 detects the presence or absence of the pigment and if the pigment is not present the aspiration system will not operate.
  • the centrifuge tube authentification system so far described is capable of wide variation.
  • the polymer of the centrifuge tube 11 may contain other additives such as dyes and pigments which will alter the light transmission, absorption or reflectivity of the polymer or which will alter the conductivity, conductance or magnetic field of the centrifuge tube.
  • the reflective object sensor 16 would be replaced by suitable alternative detecting means.
  • An additive may be of a kind which will fluoresce in the presence of ultra violet light, in which case the diode of the object sensor would of course emit such light.
  • the roughened area 14 may be produced subsequent to the moulding operation by, for example, etching or inscribing. It is preferable that the modification to the centrifuge tube necessary for authentification is not immediately apparent to the user in case the latter would attempt to use a sub-standard centrifuge tube by applying to it a similar marking.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Selon la présente invention, un tube de centrifugation (11) destiné à être utilisé dans un système automatisé d'aspiration d'échantillons biologiques du type décrit dans le document WO 9324213 possède une zone rugueuse (14) au niveau de son extrémité ouverte, ladite zone rugueuse modifiant les propriétés réfléchissantes du polymère à partir duquel est formé le tube (11) par moulage. Un détecteur d'objets réflectif (16) situé dans le col (13) d'une poignée (12) d'une sonde (10) détecte la présence ou l'absence de la zone rugueuse (14). La pompe du système d'aspiration ne fonctionne que si la zone rugueuse (14) est présente. Ceci évite qu'un tube de centrifugation (11) incorrect ne soit utilisé. Sous un autre mode de réalisation, le tube (11) ne comporte pas de zone rugueuse (14) mais le polymère utilisé pour mouler le tube contient un additif dont la présence ou l'absence est détectée par le détecteur d'objets (16).
PCT/GB2007/001711 2006-05-12 2007-05-09 Dispositif automatique d'aspiration d'échantillons et récipient destiné à être utilisé avec le dispositif Ceased WO2007132184A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0609411.4 2006-05-12
GB0609411A GB0609411D0 (en) 2006-05-12 2006-05-12 Combination of automated apparatus and container for use therewith

Publications (1)

Publication Number Publication Date
WO2007132184A1 true WO2007132184A1 (fr) 2007-11-22

Family

ID=36637362

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/001711 Ceased WO2007132184A1 (fr) 2006-05-12 2007-05-09 Dispositif automatique d'aspiration d'échantillons et récipient destiné à être utilisé avec le dispositif

Country Status (2)

Country Link
GB (1) GB0609411D0 (fr)
WO (1) WO2007132184A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052634A3 (fr) * 2008-11-06 2010-09-30 Koninklijke Philips Electronics N.V. Cuvette et procédé d'authentification d'une cuvette

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873875A (en) * 1986-06-27 1989-10-17 Prism Technology, Inc. System for optically interrogating liquid samples and for withdrawing selected sample portions
FR2726653A1 (fr) * 1994-11-07 1996-05-10 Armines Dispositif pour la collecte ou la distribution d'echatillons liquides
US5851397A (en) * 1996-05-09 1998-12-22 Itoh; Teruaki Auxiliary apparatus for sampling blood serum
US5965447A (en) * 1994-09-28 1999-10-12 Shigetoshi Sekiyama Pretreating apparatus for analytic container and automatic filling system
US5985215A (en) * 1996-09-24 1999-11-16 Hitachi, Ltd. Analyzing apparatus having a function pipette samples
WO2003078066A1 (fr) * 2002-03-13 2003-09-25 The Automation Partnership (Cambridge) Limited Distributeur de gouttelettes a faible volume
EP1464965A1 (fr) * 2004-01-15 2004-10-06 Agilent Technologies Inc. a Delaware Corporation Système et méthode de positionnement pour un dispositif de transfert de liquide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873875A (en) * 1986-06-27 1989-10-17 Prism Technology, Inc. System for optically interrogating liquid samples and for withdrawing selected sample portions
US5965447A (en) * 1994-09-28 1999-10-12 Shigetoshi Sekiyama Pretreating apparatus for analytic container and automatic filling system
FR2726653A1 (fr) * 1994-11-07 1996-05-10 Armines Dispositif pour la collecte ou la distribution d'echatillons liquides
US5851397A (en) * 1996-05-09 1998-12-22 Itoh; Teruaki Auxiliary apparatus for sampling blood serum
US5985215A (en) * 1996-09-24 1999-11-16 Hitachi, Ltd. Analyzing apparatus having a function pipette samples
WO2003078066A1 (fr) * 2002-03-13 2003-09-25 The Automation Partnership (Cambridge) Limited Distributeur de gouttelettes a faible volume
EP1464965A1 (fr) * 2004-01-15 2004-10-06 Agilent Technologies Inc. a Delaware Corporation Système et méthode de positionnement pour un dispositif de transfert de liquide

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052634A3 (fr) * 2008-11-06 2010-09-30 Koninklijke Philips Electronics N.V. Cuvette et procédé d'authentification d'une cuvette
US8665431B2 (en) 2008-11-06 2014-03-04 Koninklijke Philips N.V. Cuvette and method for authenticating a cuvette
RU2509296C2 (ru) * 2008-11-06 2014-03-10 Конинклейке Филипс Электроникс Н.В. Кювета и способ проверки подлинности кюветы

Also Published As

Publication number Publication date
GB0609411D0 (en) 2006-06-21

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