WO2007126115A1 - Prevention apparatus and prevention system of osteoporotic change - Google Patents

Abstract

An axial vibration stress applying section (7) for applying an axial vibration stress to each bone of a human body (200) is provided, and an axial vibration stress including at least a longitudinal stress or a torsional stress is applied in the body axix directions of the human body (200) from the axial vibration stress applying section (7), thus suppressing action of osteoclast. Consequently, a practitioner can easily perform prevention against osteoporotic change indicative of reduction in amount of bone.

Description

 Specification

 Prevention device for osteoporosis-like change and its prevention system

 Technical field

 TECHNICAL FIELD [0001] The present invention relates to a preventive device for osteoporosis-like change showing a decrease in bone mass and a preventive system thereof.

 Background art

 [0002] The modern society is a vehicle society represented by cars and the like, regardless of whether it is preferred or not, and there is a concern about a decrease in the amount of exercise necessary for maintaining human health. This decrease in the amount of exercise necessary to maintain human health is known to show a significant decrease in bone mass, ie, osteoporosis-like changes. Examples of methods for preventing this osteoporosis-like change include exercise therapy, drug therapy, and diet therapy.

 [0003] Also in our research, we have obtained experimental results that osteoporosis-like changes associated with the reduction of the mechanical load on the femur lead to irreversible damage to the organs after recovery from the load. For example, the present inventors have reported the following experimental results in Non-Patent Document 1 below.

 [0004] Seven-week-old Wistar male rats weighing about 200g were suspended for 9 weeks and then returned to their cages for 8 weeks and divided into control groups that were kept in cages. The hind limb femur was removed from both groups of Wistar oss rats. The femurs of Wistar oss rats with the former limb suspension do not recover in a sufficient recovery period under gravity and are locally vulnerable compared to the femurs of Wistar oss rats in the latter control group Results were obtained.

 [0005] Non-Patent Document 1: Proceedings of Symposium on Basics and Applications of Ultrasonic Electronics, Vol. 26 (published Nov. 16, 2005), P. 157

 Disclosure of the invention

[0006] As described above, the modern society is a vehicle society represented by cars, etc., and people's daily lives are sitting on a chair for a long time, for example, at work or study, and lack of exercise. It tends to be. This decrease in momentum causes a decrease in human bone mass (osteoporosis-like change). In particular, patients who are hospitalized for a long time continue to be bedridden. Therefore, osteoporosis-like changes are remarkable.

 [0007] Conventionally, there has been no effective preventive device to prevent this bone loss, that is, osteoporosis-like changes. Therefore, prevention by performing actual exercise, drug therapy, diet therapy, etc. Therefore, it was a powerful force to prevent. However, when these preventive measures are actually performed, the burden on the practitioner is extremely large, and it is difficult to easily prevent osteoporosis-like changes.

 [0008] The present invention has been made in view of the above-described problems, and an object of the present invention is to provide an osteoporosis-like change-preventing device that enables a practitioner to easily prevent osteoporosis-like change. .

 [0009] The preventive device for osteoporosis-like change of the present invention has vibration stress applying means for applying vibration stress to each bone of the human body, and axial vibration including at least longitudinal stress or torsional stress from the vibration stress applying means. By applying stress in the body axis direction of the human body, the function of osteoclasts is suppressed.

 [0010] According to the present invention, the vibrational stress applying means force is applied to the body axis direction of the human body to suppress the action of osteoclasts, and thus osteoporosis-like changes in each bone of the human body. It is possible for the practitioner to easily prevent this.

 Brief Description of Drawings

 FIG. 1 is a block diagram showing a schematic configuration of an osteoporosis-like change prevention device according to an embodiment of the present invention.

 FIG. 2 is a schematic diagram showing an example of a method for measuring walking axial vibration stress using a walking axial vibration stress measuring apparatus.

 FIG. 3 is a waveform diagram showing an example of walking axial vibration stress measured by a walking axial vibration stress measuring apparatus.

 [FIG. 4] FIG. 4 is a waveform diagram showing an example of a fundamental vibration wave modulated by an amplitude modulation section and a pseudo walking axial vibration stress caused by the fundamental vibration wave.

 FIG. 5A is a schematic diagram showing an example of axial vibration stress applied to a vibration stress receiver (human body) based on vibration oscillated from the vibrator of the axial vibration stress application unit.

[FIG. 5B] FIG. 5B shows the vibration based on the vibration of the vibrator force of the axial vibration stress application part. It is a schematic diagram which shows an example of the axial vibration stress applied to a stress receiver (human body).

 FIG. 6 is a flowchart showing a method for controlling the osteoporosis-like change prevention device according to the embodiment of the present invention.

 FIG. 7 is a schematic diagram showing an example of a second embodiment of the osteoporosis-like change prevention system according to the present invention.

 FIG. 8 is a schematic diagram showing an example of a third embodiment of the osteoporosis-like change prevention system according to the present invention.

 BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, embodiments of the present invention will be described.

 FIG. 1 is a block diagram showing a schematic configuration of an osteoporosis-like change prevention device 100 according to an embodiment of the present invention.

 [0013] An osteoporosis-like change prevention device 100 according to an embodiment of the present invention includes a walking axial vibration stress measurement device 1, a walking axial vibration stress data storage unit 2, a walking amplitude waveform generation unit 3, and a basic vibration. The wave generation unit 4, the amplitude modulation unit 5, the vibration control unit 6, the axial vibration stress application unit 7, and the axial vibration amplitude detection unit 8 are configured. In addition, the axial vibration stress applying unit 7 includes a plurality of vibrators 71a and 71b that oscillate vibration.

 The walking axial vibration stress measuring apparatus 1 measures axial vibration stress under walking conditions, that is, axial vibration stress (walking axial vibration stress) generated during walking. Here, “axial vibration stress” refers to intermittent stress in the vertical direction that receives ground force against the sole during walking. For example, the axial vibration stress corresponds to vibration stress transmitted from the radius, tibia, femur, iliac, sacrum, etc. in the body axis direction of the lumbar vertebra.

 Here, an outline of measurement of walking axial vibration stress by the walking axial vibration stress measuring apparatus 1 will be described.

 FIG. 2 is a schematic diagram showing an example of a method for measuring walking axial vibration stress using the walking axial vibration stress measuring apparatus 1.

As shown in FIG. 2, the walking axial vibration stress measuring device 1 has a dynamic pressure detection unit (dynamic pressure sensor) 11, an AZD conversion unit 12, a control unit (CPU) 13, and a monitor 14. Configured. The control unit (CPU) 13 is a program for performing control in the control unit 13. 13a is provided.

 [0017] The dynamic pressure detection unit (dynamic pressure sensor) 11 is installed, for example, on the floor surface, and detects the walking axial vibration stress (f (t)) of the subject 201 based on the control by the control unit 13. To do. Based on the control by the control unit 13, the AZD conversion unit 12 performs analog Z-digital conversion on the data of the walking axial vibration stress detected by the dynamic pressure detection unit 11. The control unit 13 comprehensively controls the operation of the walking axial vibration stress measuring device 1, and drives the dynamic pressure detection unit 11 and the AZD conversion unit 12 at a predetermined timing, and also the AZD conversion unit 12 Is stored in the walking axial vibration stress data storage unit 2 and the walking axial vibration stress data is displayed on the monitor 14 as necessary. The monitor 14 displays walking axial vibration stress data and the like based on the control by the control unit 13.

FIG. 3 is a waveform diagram showing an example of walking axial vibration stress measured by the walking axial vibration stress measuring apparatus 1. In FIG. 3, the vertical axis represents walking axial vibration stress f (kgZcm ² ), and the horizontal axis represents time t (seconds).

 Returning to FIG. 1, the walking axial vibration stress data storage unit 2 stores the waveform data of the walking axial vibration stress measured by the walking axial vibration stress measuring apparatus 1 as walking axial vibration stress data. Is. In this walking axial vibration stress data storage unit 2, for example, waveform data of walking axial vibration stress shown in FIG. 3 is stored as walking axial vibration stress data.

 [0020] The walking amplitude waveform generation unit 3 extracts walking axial vibration stress data from the walking axial vibration stress data storage unit 2, and generates a walking amplitude waveform related to the extracted walking axial vibration stress data.

 [0021] The fundamental vibration wave generator 4 generates a sine wave (fundamental vibration wave) having a constant vibration amplitude. Here, the fundamental vibration wave generating unit 4 generates a fundamental vibration wave outside the audible frequency range (for example, a sine wave having a vibration frequency of 10 kHz or more).

The amplitude modulation unit 5 modulates the sine wave (fundamental vibration wave) from the fundamental vibration wave generation unit 4 with the walking amplitude related to the walking amplitude waveform generated by the walking amplitude waveform generation unit 3.

FIG. 4 is a waveform diagram showing an example of the fundamental vibration wave modulated by the amplitude modulation section 5 and the pseudo walking axial vibration stress caused by the fundamental vibration wave. In Fig. 4, the vertical axis is pseudo-walking axiality The vibrational stress f (kg / cm ² ) is shown, and the horizontal axis shows time t (seconds). Further, in FIG. 4, what is indicated by a broken line is a fundamental vibration wave (for example, a sine wave having a vibration frequency of 10 kHz or more) modulated by the amplitude modulation section 5.

 Returning to FIG. 1, the vibration control unit 6 controls vibrations oscillated from the vibrators 71 a and 71 b of the axial vibration stress application unit 7 based on the vibration wave modulated by the amplitude modulation unit 5.

 [0025] The axial vibration stress applying unit 7 oscillates vibrations from the vibrators 71a and 71b based on the control by the vibration control part 6, and converts the axial vibration stress based on the vibrations by the vibrators 71a and 71b to vibration stress. Applied to receiver 200.

 Here, as the vibration stress receiving body 200, an animal body having a skeleton such as a human body can be applied, and in the present embodiment, it is referred to as a “human body”. Also, the axial vibration stress applied to the vibration stress receiver (human body) 200 from the axial vibration stress application unit 7 is a vibration frequency higher than the sensory sensation in the human body (vibration stress receiver 200), that is, human cannot detect. Vibration frequency (for example, vibration frequency of 10kHz or more outside the audible frequency range).

 Next, the axial vibration stress applied to the vibration stress receiver (human body) 200 based on the vibrations oscillated from the vibrators 71a and 71b of the axial vibration stress application unit 7 will be described.

 FIG. 5A and FIG. 5B are examples of axial vibration stress applied to a vibration stress receiver (human body) 200 based on vibrations oscillated from the vibrators 71a and 71b of the axial vibration stress application unit 7. FIG. Here, FIG. 5A shows an example in which axial vibration stress is applied from the sole of the vibration stress receiver (human body) 200.

 As shown in FIGS. 5A and 5B, the vibrators 71a and 71b of the axial vibration stress application unit 7 are attached to the vibration stress application table 72, which is not shown in FIG. As shown in FIG. 5A, the vibrators 71a and 71b oscillate in a direction of the body axis of the vibration stress receiving body (human body) 200 to give axial vibration stress of longitudinal stress and torsional stress. As a result, axial vibration stress based on the waveform of axial vibration stress generated during walking is applied to each bone 200a of the vibration stress receiver (human body) 200 in the body axis direction, and osteoclasts in each bone 200a. Is suppressed.

Here, as shown in FIGS. 5A and 5B, the vibration stress application table 72 is formed by combining, for example, a horizontal plate 72a and a vertical plate 72b. The horizontal plate 72a and the vibrator 71a Vibration stress based on the vibration by the vibrator 71b is applied to the vertical plate 72b. Specifically, the vibrator 71 a is a vibrator for applying a vibration stress in the vertical direction to the horizontal plate 72 a and applying a longitudinal stress in the body axis direction of the vibration stress receiver (human body) 200. In addition, the vibrator 71b applies vibration stress to the position 72b at the end of the vertical plate 72b, and couples about the position 72a with respect to the vertical plate 72b.

 This is a vibrator for generating a vibration stress related to 0 0 and applying a torsional stress in the body axis direction of the vibration stress receiver (human body) 200.

 Returning to FIG. 1, the axial vibration amplitude detection unit 8 detects the vibration amplitude in the vibration stress receiver (human body) 200 to which the axial vibration stress is applied from the axial vibration stress application unit 7. Here, the purpose of detecting the vibration amplitude in the vibration stress receiver (human body) 200 is to have axiality at the bending joint, etc. according to the posture state of the vibration stress receiver (human body) 200 such as standing, bed rest, and stool. The propagation direction of vibration stress changes, the active component of axial vibration stress in the body axis direction of the vibration stress receiver (human body) 200 is attenuated, and the vibration connection efficiency with the application surface of axial vibration stress is reduced. Since, for example, it depends on the conditions of footwear, etc., vibration is applied to the vibration stress receiver (human body) 200 in order to add a vibration amplitude related to constant axial vibration stress to the vibration stress receiver (human body) 200. Detect amplitude.

 Then, based on the vibration amplitude of the vibration stress receiver (human body) 200 detected by the axial vibration amplitude detector 8, the vibration controller 6 determines the vibration amplitude of the vibration wave modulated by the amplitude modulator 5. The axial vibration stress applying unit 7 is controlled so that the vibration based on the adjusted vibration wave is oscillated from the vibrators 71a and 71b of the axial vibration stress applying unit 7.

 [0033] Next, a method for controlling the osteoporosis-like change prevention device 100 according to an embodiment of the present invention will be described.

 FIG. 6 is a flowchart showing a method for controlling an osteoporosis-like change prevention device according to an embodiment of the present invention.

First, in step S1, the walking axial vibration stress measuring apparatus 1 determines the axial vibration stress under the walking condition of the person 201 to be measured, that is, the axial vibration stress generated when the person 201 to be walked (walking). Measure axial vibration stress). The measurement by the walking axial vibration stress measuring device 1 is performed, for example, by the measuring method shown in FIG. [0035] Subsequently, in step S2, the walking axial vibration stress measuring device 1 (control unit 13) measures the measured walking axial vibration stress data (for example, the waveform data of the walking axial vibration stress shown in FIG. 3). Is stored in the walking axial vibration stress data storage unit 2 as walking axial vibration stress data.

 Subsequently, in step S3, the walking amplitude waveform generation unit 3 extracts the walking axial vibration stress data from the walking axial vibration stress data storage unit 2, and extracts the extracted walking axial vibration. A gait amplitude waveform related to the stress data is generated.

[0037] Subsequently, in step S4, the amplitude modulation unit 5 performs the sine wave from the fundamental vibration wave generation unit 4.

 Amplitude modulation of the (basic vibration wave) is performed with the walking amplitude related to the walking amplitude waveform generated by the walking amplitude waveform generator 3.

 Subsequently, in step S5, the axial vibration stress application unit 7 oscillates vibrations based on the vibration wave modulated by the amplitude modulation unit 5 from the vibrators 71a and 71b based on the control by the vibration control unit 6. Then, the axial vibration stress based on the vibration is applied to the vibration stress receiver 200.

 Subsequently, in step S6, the axial vibration amplitude detector 8 detects the vibration amplitude in the vibration stress receiver (human body) 200 to which the axial vibration stress is applied. .

 Subsequently, in step S 7, the vibration control unit 6 performs the vibration modulated by the amplitude modulation unit 5 based on the vibration amplitude of the vibration stress receiver (human body) 200 detected by the axial vibration amplitude detection unit 8. The axial vibration stress applying unit 7 is controlled so that the vibration amplitude of the dynamic wave is adjusted and vibration based on the adjusted vibration wave is oscillated from the vibrators 71a and 71b of the axial vibration stress applying unit 7. The In other words, the vibration control unit 6 controls the vibrations oscillated from the vibrators 71a and 71b based on the vibration amplitude of the vibration stress receiver (human body) 200 detected by the axial vibration amplitude detection unit 8, and the axial vibration The axial vibration stress applied from the stress application unit 7 is controlled.

[0041] By passing through the processes from step S1 to step S7 described above, axial vibration stress that promotes prevention of osteoporosis-like changes in each bone 200a is applied to the vibration stress receiver (human body) 200. Is possible. More specifically, the bone is growing axially, and piezoelectricity is generated by the axial vibration stress according to the present embodiment, and this piezoelectricity becomes a command signal to suppress the action of osteoclasts, Prevents osteoporosis-like changes in bone. In the embodiment of the present invention, as shown in FIG. 5A, the longitudinal stress and the axial vibration stress applied in the body axis direction of the vibration stress receiver (human body) 200 from the axial vibration stress application unit 7 are as follows. In the present invention, axial vibration stress including longitudinal stress or torsional stress is applied in the direction of the body axis of the vibration stress receiver (human body) 200. Any form is applicable. In this case, when applying axial vibration stress including only longitudinal stress, for example, the vibration control unit 6 performs control to drive only the vibrator 71a and applies axial vibration stress including only torsional stress. In this case, for example, the vibration control unit 6 performs a control for driving only the vibrator 7 lb.

 [0043] (Prevention system for osteoporosis-like changes)

 Next, the form of the osteoporosis-like change prevention system using the above-described osteoporosis-like change prevention device 100 according to the embodiment of the present invention will be described.

[0044] As a first form of the osteoporosis-like change prevention system, the axial vibration stress applying unit 7 in the osteoporosis-like change prevention device 100 is installed in a predetermined region of the floor surface, and vibrations are located in the predetermined region. Axial vibration stress is applied to the stress receiving body (human body) 200 in the body axis direction.

 [0045] Next, a second mode of the osteoporosis-like change prevention system will be described.

 FIG. 7 is a schematic diagram showing an example of a second embodiment of the osteoporosis-like change prevention system according to the present invention.

[0046] As a second form of the osteoporosis-like change prevention system, as shown in FIG. 7, the axial vibration stress applying unit 7 in the osteoporosis-like change prevention device 100 is connected to the seat surface of the chair 310 ( Axial vibration stress application section 7a), chair 310 backrest (axial vibration stress application section 7b), chair 310 footrest (axial vibration stress application section 7c), etc. From the applying units 7a to 7c, axial vibration stress is applied to the vibration stress receiving body (human body) 200 sitting on the chair 310 in the body axis direction. In this case, the axial vibration stress applying unit 7a applies the axial vibration stress in the body axis direction (the pelvic force is also directed toward the head) of the vibration stress receiver (human body) 200, and the axial vibration is applied. Axial vibration stress is applied to the body axis direction (direction connecting the pelvis and head) from the back of the vibration stress receiver (human body) 200 by the stress application unit 7b, and the axial vibration response The force application unit 7c applies an axial vibration stress in the direction of the body axis of the vibration stress receiver (human body) 200 (direction from the sole to the knee). At this time, the axial vibration stress application unit 7c is arranged so that the axial vibration stress is also applied to the arch or rib force of the sole of the vibration stress receiver (human body) 200. Note that the chair 310 is not limited to the car chair shown in FIG. 7, and a vehicle chair such as an airplane chair, a wheelchair chair, or a chair used at a desk can also be applied.

 [0047] For example, as shown in FIG. 7, when an osteoporosis-like change prevention system is applied to a car chair 310, for example, an axial vibration stress applying unit 7 is further installed on the accelerator pedal of the car. Also, it is possible to apply axial vibration stress to the sole of the vibration stress receiver (human body) 200. In this case, the axial vibration stress applied to the vibration stress receiver (human body) 200 from the axial vibration stress applying unit 7 is not to disturb the operational feeling of the vibration stress receiver (human body) 200. The vibration frequency is higher than the perceptual sensation of the human body (vibration stress receiver 200), that is, the vibration frequency that cannot be detected by humans.

 [0048] Next, a third mode of the osteoporosis-like change prevention system will be described.

 FIG. 8 is a schematic diagram showing an example of a third embodiment of the osteoporosis-like change prevention system according to the present invention.

 [0049] As a third form of the osteoporosis-like change prevention system, as shown in FIG. 8, the axial vibration stress application unit 7 in the osteoporosis-like change prevention device 100 is placed on the bed 320. The position of the foot of the received vibration stress receiver (human body) 200 (axial vibration stress application unit 7d) and the predetermined position of the bed surface corresponding to the waist position of the vibration stress receiver (human body) 200 (apply axial vibration stress) The axial vibration stress is applied to the vibration stress receiving body (human body) 200 lying on the floor bed 320 from each axial vibration stress applying section 7d and 7e. give.

[0050] In this case, the axial vibration stress applying unit 7d applies axial vibration stress from the sole of the vibration stress receiving body (human body) 200 to the body axis direction (the sole force is also directed toward the head). Axial vibration stress is applied from the pelvis of the vibration stress receiver (human body) 200 to the body axis direction (the direction connecting the sole and the head) by the application unit 7e. At this time, for the axial vibration stress application unit 7d, the arch or rib force of the sole of the vibration stress receiver (human body) 200 or the axial vibration stress is applied. To be arranged.

 [0051] As a fourth form of the osteoporosis-like change prevention system, the axial vibration stress applying unit 7 in the osteoporosis-like change prevention device 100 is installed in a structure provided in the spacecraft, and the structure is provided. An axial vibration stress is applied to the body 200 of the vibration stress receiving body (human body) in the body axis direction.

 [0052] In the osteoporosis-like change prevention system according to the first to fourth embodiments described above, the axial vibration stress applied from the axial vibration stress application unit 7 is caused by the vibration stress receiver (human body) 200 standing up. In this state, it is preferable to supply the sole force, but it may be difficult depending on where the axial vibration stress applying unit 7 is installed. For example, when installed on a chair 310, the axial vibration stress to which the sole force is supplied when the vibration stress receiver (human body) 200 is seated on the waist is attenuated by flexion of the knee joint and hip joint, and the femur and spine Not transmitted in the major axis direction. In this case, as shown in FIG. 7, the axial vibration stress applying unit 7 (in the position where axial vibration stress is applied in the longitudinal direction of the femur and spinal column (ie, in the body axis direction) from the seating surface. Install the axial vibration stress application section 7a).

 According to the present embodiment, axial vibration stress is applied from the axial vibration stress application unit 7 in the body axis direction of the vibration stress receiver (human body) 200 to suppress the function of osteoclasts. Therefore, it becomes possible for the practitioner to easily prevent osteoporosis-like changes in each bone of the vibration stress receiver (human body) 200.

 Each means of FIG. 1 constituting the osteoporosis-like change prevention device 100 according to the present embodiment described above, and each step of FIG. 6 showing a control method of the osteoporosis-like change prevention device 100 are the RAM of the computer. This can be realized by running a program stored in ROM or ROM. This program and a computer-readable storage medium storing the program are included in the present invention.

Specifically, the program is recorded on a storage medium such as a CD-ROM, or provided to a computer via various transmission media. As a storage medium for recording the program, besides a CD-ROM, a flexible disk, a hard disk, a magnetic tape, a magneto-optical disk, a nonvolatile memory card, or the like can be used. On the other hand, as the transmission medium of the program, program information is propagated and supplied as a carrier wave. It is possible to use communication media (wired lines such as optical fibers, wireless lines, etc.) in computer network (LAN, WAN such as the Internet, wireless communication network, etc.) system.

 [0056] Further, the function of the osteoporosis-like change prevention device 100 according to the present embodiment is not only realized by executing a program supplied by a computer. When the program runs on a computer, the function of the osteoporosis-like change prevention device 100 according to the present embodiment is realized in cooperation with an operating system (OS) or other application software. A powerful program is included in the present invention. In addition, when all or part of the processing of the supplied program is performed by the function expansion board or function expansion unit of the computer, the function of the osteoporosis-like change prevention device 100 according to the present embodiment is realized. A powerful program is included in the present invention.

 Industrial applicability

[0057] According to the present invention, the action of osteoclasts is suppressed by applying axial vibration stress in the direction of the human body axis from the vibration stress applying means (axial vibration stress applying unit 7). The practitioner can easily prevent osteoporosis-like changes in each bone of the human body.

[0058] As shown in the osteoporosis-like change prevention system, the vibration stress applying means (axial vibration stress applying unit 7) of the osteoporosis-like change prevention device according to the present embodiment is used. The vibration placed on the surface, chair backrest or chair footrest, car accelerator pedal, bed, or other structure provided in the spacecraft. It can be used when applying axial vibration stress to the stress receiver (human body). For example, for a bedridden patient who has been hospitalized for a long period of time, wearing the bedbed bed or the bed bed patient with the vibration stress applying means (axial vibration stress applying unit 7) of the osteoporosis-like change prevention device, It is also possible to use it by applying axial vibration stress to the vibration stress receiver (human body) from the applying means!]. Also, for example, for astronauts who have been in outer space for a long time, the preventive device for osteoporosis-like change is installed in the structure provided in the spacecraft as described above, and the astronaut's It can also be used to prevent osteoporosis-like changes.

Claims

The scope of the claims  [1] having vibration stress applying means for applying vibration stress to each bone of the human body,  Prevention of osteoporosis-like change characterized by suppressing the action of osteoclasts by applying axial vibration stress including at least longitudinal stress or torsional stress in the body axis direction of the human body from the vibration stress applying means. Instruments.  2. The preventive device for osteoporosis-like change according to claim 1, wherein the axial vibration stress is composed of a synthetic stress obtained by synthesizing the longitudinal stress and the torsional stress. 3. The preventive device for osteoporosis-like change according to claim 1, wherein the axial vibration stress is applied in the body axis direction from a sole or pelvis of the human body. [4] The osteoporosis-like change prediction according to claim 3, wherein when the axial vibration stress is applied to the sole, it is applied in the body axis direction from an arch or a rib of the sole. Armor.  5. The osteoporosis according to claim 1, wherein the vibration stress applying means applies the axial vibration stress based on a waveform of the axial vibration stress generated during walking in the body axis direction. Preventive device for changes.  [6] The vibration stress applying means includes the axis based on the pseudo-walking axial vibration stress waveform obtained by modulating a vibration wave outside the audible frequency region using a waveform of the axial vibration stress generated during walking. The preventive device for osteoporosis-like change according to claim 1, wherein sexual vibration stress is applied in the body axis direction.  [7] vibration amplitude detecting means for detecting the vibration amplitude of the human body to which the axial vibration stress is applied from the vibration stress applying means;  Control means for controlling the axial vibration stress to be applied based on the vibration amplitude detected by the vibration amplitude detection means;  The preventive device for osteoporosis-like change according to claim 1, further comprising: [8] It has vibration stress applying means for applying vibration stress to each bone of the human body, and axial vibration stress including at least longitudinal stress or torsional stress is applied from the vibration stress applying means in the body axis direction of the human body. By using an osteoporosis-like change prevention device that suppresses the action of osteoclasts, The axial vibration by the vibration stress applying means in at least one of a seat surface of the chair on which the human body is placed, a backrest of the chair, and a footrest portion of the chair in the body axis direction of the human body. An osteoporosis-like change prevention system characterized by being configured to apply stress.  A vibration stress applying means for applying a vibration stress to each bone of the human body, and applying an axial vibration stress including at least a longitudinal stress or a torsional stress in the body axis direction of the human body from the vibration stress applying means, Using a preventive device for osteoporosis-like changes that suppress the action of osteoclasts,  An osteoporosis-like change prevention system, characterized in that the axial vibration stress by the vibration stress applying means is applied in the body axis direction of the human body from the bed on which the human body is placed.