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WO2007123691A3 - Méthode de traitement de troubles de la coagulation sanguine - Google Patents

Méthode de traitement de troubles de la coagulation sanguine Download PDF

Info

Publication number
WO2007123691A3
WO2007123691A3 PCT/US2007/007924 US2007007924W WO2007123691A3 WO 2007123691 A3 WO2007123691 A3 WO 2007123691A3 US 2007007924 W US2007007924 W US 2007007924W WO 2007123691 A3 WO2007123691 A3 WO 2007123691A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood coagulation
coagulation disorders
treating blood
lipidic particles
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/007924
Other languages
English (en)
Other versions
WO2007123691A2 (fr
Inventor
Sathy V Balu-Iyer
Robert M Straubinger
Razvan Michlea
Aaron Peng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of WO2007123691A2 publication Critical patent/WO2007123691A2/fr
Publication of WO2007123691A3 publication Critical patent/WO2007123691A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne une méthode de traitement de troubles de la coagulation sanguine. Cette méthode consiste à administrer à un individu des compositions renfermant des particules lipidiques comprenant la phospatidylcholine, le phosphatidylinositol et le cholestérol. Un ou plusieurs peptides, polypeptides ou protéines intervenant dans la cascade de la coagulation sanguine sont associés aux particules lipidiques.
PCT/US2007/007924 2006-03-30 2007-03-30 Méthode de traitement de troubles de la coagulation sanguine Ceased WO2007123691A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78741106P 2006-03-30 2006-03-30
US78758606P 2006-03-30 2006-03-30
US60/787,411 2006-03-30
US60/787,586 2006-03-30
US86506206P 2006-11-09 2006-11-09
US60/865,062 2006-11-09

Publications (2)

Publication Number Publication Date
WO2007123691A2 WO2007123691A2 (fr) 2007-11-01
WO2007123691A3 true WO2007123691A3 (fr) 2008-05-29

Family

ID=38625470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/007924 Ceased WO2007123691A2 (fr) 2006-03-30 2007-03-30 Méthode de traitement de troubles de la coagulation sanguine

Country Status (1)

Country Link
WO (1) WO2007123691A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123258A1 (fr) * 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomes pour l'administration de médicaments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAMANI K. ET AL.: "Passive Transfer of Polyethylene glycol to Liposomal-Recombinant Human FVIII Enhances its Efficacy in a Murine Model for Hemophilia A", J. PHARM. SCIENCES, February 2008 (2008-02-01), pages 1 - 12, XP008130854, DOI: doi:10.1002/JPS.21266 *
RAMANI K. ET AL.: "Phosphatidylserine Containing Liposomes Reduce Immunogenicity of Recombinant Human Factor VIII (rFVIII) in a Murine Model of Hemophilia A", J. PHARM. SCIENCES, vol. 97, April 2008 (2008-04-01), pages 1386 - 1398, XP008130853 *

Also Published As

Publication number Publication date
WO2007123691A2 (fr) 2007-11-01

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