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WO2007120198A3 - Materials and methods for improved microbial production of organic compounds - Google Patents

Materials and methods for improved microbial production of organic compounds Download PDF

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Publication number
WO2007120198A3
WO2007120198A3 PCT/US2006/043380 US2006043380W WO2007120198A3 WO 2007120198 A3 WO2007120198 A3 WO 2007120198A3 US 2006043380 W US2006043380 W US 2006043380W WO 2007120198 A3 WO2007120198 A3 WO 2007120198A3
Authority
WO
WIPO (PCT)
Prior art keywords
osmoprotectants
betaine
materials
methods
organic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/043380
Other languages
French (fr)
Other versions
WO2007120198A2 (en
Inventor
Lonnie O'neal Ingram
Keelnatham T Shanmugam
Shengde Zhou
Thomas B Causey
Lorraine P Yomano
Tammy B Grabar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/501,137 external-priority patent/US7629162B2/en
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of WO2007120198A2 publication Critical patent/WO2007120198A2/en
Publication of WO2007120198A3 publication Critical patent/WO2007120198A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

In accordance with the subject invention, osmoprotectants, such as betaine, may be used to increase the productivity and titer of anaerobic and aerobic fermentation with E. coli. and other microbes. Betaine serves as a protective osmolyte during fermentations with high concentrations of sugars or products, replacing the need to divert carbon and energy into native osmoprotectants such as glutamate and trehalose. Thus, in accordance with the subject invention, betaine and/or other osmoprotectants can be added to media and improve the rates of biological conversion of sugars into chemicals such as organic acids.
PCT/US2006/043380 2005-11-08 2006-11-07 Materials and methods for improved microbial production of organic compounds Ceased WO2007120198A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US73444305P 2005-11-08 2005-11-08
US60/734,443 2005-11-08
US76157606P 2006-01-24 2006-01-24
US60/761,576 2006-01-24
US79961906P 2006-05-11 2006-05-11
US60/799,619 2006-05-11
US11/501,137 US7629162B2 (en) 2005-08-10 2006-08-08 Materials and methods for efficient lactic acid production
US11/501,137 2006-08-08

Publications (2)

Publication Number Publication Date
WO2007120198A2 WO2007120198A2 (en) 2007-10-25
WO2007120198A3 true WO2007120198A3 (en) 2007-12-21

Family

ID=38609954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043380 Ceased WO2007120198A2 (en) 2005-11-08 2006-11-07 Materials and methods for improved microbial production of organic compounds

Country Status (1)

Country Link
WO (1) WO2007120198A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101914581B (en) * 2010-07-27 2012-05-23 南京工业大学 Method for improving fermentation yield of polyunsaturated fatty acid
NL2007353C2 (en) * 2011-09-05 2013-03-07 Kwr Water B V Solution comprising an osmotic agent and method of extracting water using said solution.
WO2015087226A1 (en) 2013-12-13 2015-06-18 Basf Se Recombinant microorganism for improved production of fine chemicals
ES2821418T3 (en) 2014-07-23 2021-04-26 Purac Biochem Bv Genetically modified thermophilic bacteria producing (R) -lactic acid
JP6914846B2 (en) 2015-03-18 2021-08-04 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ Recombinant microorganisms for improving fine chemical production
JP7071124B2 (en) 2015-06-04 2022-05-18 ビーエーエスエフ ソシエタス・ヨーロピア Recombinant microorganisms for improving fine chemical production
US10837034B2 (en) 2015-06-12 2020-11-17 Basf Se Recombinant microorganism for improved production of alanine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818268A (en) * 1985-09-16 1989-04-04 Spawn Mate, Inc. Osmoprotectant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818268A (en) * 1985-09-16 1989-04-04 Spawn Mate, Inc. Osmoprotectant

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CAYLEY S. ET AL.: "Origins of the osmoprotective properties of betaine and proline in Escherichia coli K-12", J. BACTERIOL., vol. 174, no. 5, 1992, pages 1586 - 1595 *
PURVIS J.E. ET AL.: "Enhanced trehalose production improves growth of Escherichia coli under osmotic stress", APPL. ENVIRON. MICROBIOL., vol. 71, no. 7, July 2005 (2005-07-01), pages 3761 - 3769 *
UNDERWOOD S.A. ET AL.: "Lack of protective osmolytes limits final cell density and volumetric productivity of ethanologenic Escherichia coli KO11 during xylose fermentation", APPL. ENVIRON. MICROBIOL., vol. 70, no. 5, 2004, pages 2734 - 2740 *
ZHOU S. ET AL.: "Betaine tripled the volumetric productivity of D(-)-lactate by Escherichia coli strain SZ132 in mineral salts medium", BIOTECHNOL. LETT., vol. 28, no. 9, May 2006 (2006-05-01), pages 671 - 676 *
ZHOU S. ET AL.: "Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110", APPL. ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 399 - 407 *

Also Published As

Publication number Publication date
WO2007120198A2 (en) 2007-10-25

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