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WO2007119109A3 - Processes for preparing tegaserod maleate and pharmaceutical compositions containing it - Google Patents

Processes for preparing tegaserod maleate and pharmaceutical compositions containing it Download PDF

Info

Publication number
WO2007119109A3
WO2007119109A3 PCT/IB2006/004222 IB2006004222W WO2007119109A3 WO 2007119109 A3 WO2007119109 A3 WO 2007119109A3 IB 2006004222 W IB2006004222 W IB 2006004222W WO 2007119109 A3 WO2007119109 A3 WO 2007119109A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
hydroiodide
pharmaceutical compositions
compositions containing
tegaserod
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/004222
Other languages
French (fr)
Other versions
WO2007119109A2 (en
Inventor
Montero Maria Carme Burgarolas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Publication of WO2007119109A2 publication Critical patent/WO2007119109A2/en
Anticipated expiration legal-status Critical
Publication of WO2007119109A3 publication Critical patent/WO2007119109A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to a new process for the production of tegaserod maleate that includes the isolation of tegaserod hydroiodide as an intermediate. In particular, the invention provides an improved process for preparing 3-(5-methoxy-lH-indol-3- ylmethylene)-N-pentylcarbazimidamide hydrogen maleate (i.e., tegaserod maleate). This process includes reacting 5-methoxyindole-3-carbaldehyde with N-pentyl-N'- aminoguanidine hydroiodide and isolating solid 3-(5-methoxy-lH-indol-3-ylmethylene)-N- pentylcarbazimidamide hydroiodide (i.e., tegaserod hydroiodide).
PCT/IB2006/004222 2005-10-06 2006-10-05 Processes for preparing tegaserod maleate and pharmaceutical compositions containing it Ceased WO2007119109A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US72396205P 2005-10-06 2005-10-06
US60/723,962 2005-10-06
US72528205P 2005-10-12 2005-10-12
US60/725,282 2005-10-12
US80896006P 2006-05-30 2006-05-30
US60/808,960 2006-05-30

Publications (2)

Publication Number Publication Date
WO2007119109A2 WO2007119109A2 (en) 2007-10-25
WO2007119109A3 true WO2007119109A3 (en) 2008-06-12

Family

ID=38514208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/004222 Ceased WO2007119109A2 (en) 2005-10-06 2006-10-05 Processes for preparing tegaserod maleate and pharmaceutical compositions containing it

Country Status (2)

Country Link
AR (1) AR058078A1 (en)
WO (1) WO2007119109A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015794A1 (en) * 2008-08-07 2010-02-11 Generics [Uk] Limited Novel polymorphic forms of tegaserod

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014544A1 (en) * 2003-07-24 2005-02-17 Novartis Ag Stable modifications of tegaserod hydrogen maleate
WO2006116953A1 (en) * 2005-05-02 2006-11-09 Zentiva, A.S. A method for the preparation of tegaserod and slected salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014544A1 (en) * 2003-07-24 2005-02-17 Novartis Ag Stable modifications of tegaserod hydrogen maleate
WO2006116953A1 (en) * 2005-05-02 2006-11-09 Zentiva, A.S. A method for the preparation of tegaserod and slected salts thereof

Also Published As

Publication number Publication date
AR058078A1 (en) 2008-01-23
WO2007119109A2 (en) 2007-10-25

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