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WO2007114902A3 - Composés d'alkylthiobenzylpipéridine - Google Patents

Composés d'alkylthiobenzylpipéridine Download PDF

Info

Publication number
WO2007114902A3
WO2007114902A3 PCT/US2007/008142 US2007008142W WO2007114902A3 WO 2007114902 A3 WO2007114902 A3 WO 2007114902A3 US 2007008142 W US2007008142 W US 2007008142W WO 2007114902 A3 WO2007114902 A3 WO 2007114902A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
compound
treating
effective amount
therapeutically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/008142
Other languages
English (en)
Other versions
WO2007114902A2 (fr
Inventor
Mohammad Marzabadi
Kim Andersen
Bin Chen
Michael Reitman
Yu Jiang
Eman Eldemenky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of WO2007114902A2 publication Critical patent/WO2007114902A2/fr
Publication of WO2007114902A3 publication Critical patent/WO2007114902A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne des composés d'alkylthiobenzylpipéridine constituant des ligands au niveau du récepteur MCHI. L'invention propose une composition pharmaceutique comprenant une quantité thérapeutiquement suffisante d'un composé de l'invention et un excipient pharmaceutiquement admis. L'invention concerne également un procédé permettant de traiter un sujet soufrant de dépression, par administration d'une quantité thérapeutiquement efficace d'un composé de l'invention. L'invention concerne aussi un procédé permettant de traiter un sujet soufrant d'anxiété, par administration d'une quantité thérapeutiquement efficace d'un composé de l'invention. L'invention concerne en outre un procédé permettant de traiter un sujet soufrant d'obésité, par administration d'une quantité thérapeutiquement efficace d'un composé de l'invention. Enfin, l'invention concerne l'utilisation d'un composé de l'invention pour la fabrication d'un médicament pour le traitement d'un sujet souffrant de dépression, d'anxiété ou d'obésité.
PCT/US2007/008142 2006-04-04 2007-04-02 Composés d'alkylthiobenzylpipéridine Ceased WO2007114902A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78927406P 2006-04-04 2006-04-04
US60/789,274 2006-04-04

Publications (2)

Publication Number Publication Date
WO2007114902A2 WO2007114902A2 (fr) 2007-10-11
WO2007114902A3 true WO2007114902A3 (fr) 2008-07-03

Family

ID=38564129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/008142 Ceased WO2007114902A2 (fr) 2006-04-04 2007-04-02 Composés d'alkylthiobenzylpipéridine

Country Status (1)

Country Link
WO (1) WO2007114902A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (fr) 2011-03-08 2015-02-18 Sanofi Dérivés d'oxathiazine tétra-substitués, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
CN103848767B (zh) * 2014-01-27 2016-08-17 华东师范大学 一种芳基硫醚类化合物的合成方法
CN114539073A (zh) * 2022-02-18 2022-05-27 郑州萃智医药科技有限公司 3-溴-2-氯-4,6-二氟苯胺的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists

Also Published As

Publication number Publication date
WO2007114902A2 (fr) 2007-10-11

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