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WO2007110624A3 - Reactif immobilise - Google Patents

Reactif immobilise Download PDF

Info

Publication number
WO2007110624A3
WO2007110624A3 PCT/GB2007/001089 GB2007001089W WO2007110624A3 WO 2007110624 A3 WO2007110624 A3 WO 2007110624A3 GB 2007001089 W GB2007001089 W GB 2007001089W WO 2007110624 A3 WO2007110624 A3 WO 2007110624A3
Authority
WO
WIPO (PCT)
Prior art keywords
immobilised
immobilised reagent
phosphorus
atom
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/001089
Other languages
English (en)
Other versions
WO2007110624A2 (fr
Inventor
Mark Bradley
Carole Bruckler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Edinburgh
Original Assignee
University of Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Edinburgh filed Critical University of Edinburgh
Publication of WO2007110624A2 publication Critical patent/WO2007110624A2/fr
Publication of WO2007110624A3 publication Critical patent/WO2007110624A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un réactif cyclique immobilisé de phosphitylation ou de phosphorylation, comprenant une fonction phosphinyle ou phosphoryle, l'atome de phosphore (III) ou l'atome de phosphore (V) étant respectivement lié à et dans un système cyclique.
PCT/GB2007/001089 2006-03-27 2007-03-26 Reactif immobilise Ceased WO2007110624A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0606038.8 2006-03-27
GB0606038A GB0606038D0 (en) 2006-03-27 2006-03-27 Immobilised reagent

Publications (2)

Publication Number Publication Date
WO2007110624A2 WO2007110624A2 (fr) 2007-10-04
WO2007110624A3 true WO2007110624A3 (fr) 2008-04-03

Family

ID=36384204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/001089 Ceased WO2007110624A2 (fr) 2006-03-27 2007-03-26 Reactif immobilise

Country Status (2)

Country Link
GB (1) GB0606038D0 (fr)
WO (1) WO2007110624A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009012640A1 (de) 2009-03-09 2010-09-30 Freie Universität Berlin Mit einer Phosphoamidatgruppe modifizierte Verbindung und deren Verwendung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008432A1 (fr) * 2001-07-16 2003-01-30 Isis Pharmaceuticals, Inc. Procede de preparation de nucleosides triphosphates modifies en position alpha et composes obtenus conformement a ce procede

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008432A1 (fr) * 2001-07-16 2003-01-30 Isis Pharmaceuticals, Inc. Procede de preparation de nucleosides triphosphates modifies en position alpha et composes obtenus conformement a ce procede

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURGESS, K. AND COOK, D.: "Synthesis of nucleoside triphosphates", CHEM. REV., vol. 100, 2000, pages 2047 - 2059, XP002464530 *
PARANG, K. ET AL.: "Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides", ORG. LETT., vol. 7, 2005, pages 5589 - 5592, XP002464531 *

Also Published As

Publication number Publication date
WO2007110624A2 (fr) 2007-10-04
GB0606038D0 (en) 2006-05-03

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