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WO2007106378A2 - Filtre pour veine cave formé à partir d'un tube - Google Patents

Filtre pour veine cave formé à partir d'un tube Download PDF

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Publication number
WO2007106378A2
WO2007106378A2 PCT/US2007/006003 US2007006003W WO2007106378A2 WO 2007106378 A2 WO2007106378 A2 WO 2007106378A2 US 2007006003 W US2007006003 W US 2007006003W WO 2007106378 A2 WO2007106378 A2 WO 2007106378A2
Authority
WO
WIPO (PCT)
Prior art keywords
section
filter
appendages
filter according
shape memory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/006003
Other languages
English (en)
Other versions
WO2007106378A3 (fr
Inventor
Robert M. Carr, Jr.
Andrzej J. Chanduszko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CR Bard Inc
Original Assignee
CR Bard Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CR Bard Inc filed Critical CR Bard Inc
Publication of WO2007106378A2 publication Critical patent/WO2007106378A2/fr
Publication of WO2007106378A3 publication Critical patent/WO2007106378A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/0105—Open ended, i.e. legs gathered only at one side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/0103—With centering means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2002/016—Filters implantable into blood vessels made from wire-like elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/005—Rosette-shaped, e.g. star-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical

Definitions

  • IVC filters are devices configured for insertion into a blood vessel to capture particles that may be present in the blood stream which, if transported to, for example, the lungs could result in serious complications and even death.
  • IVC filters are utilized in patients who have a contraindication to anticoagulation or in patients developing clinically apparent deep vein thrombosis (DVT) and/or pulmonary embolism (PE).
  • DVT deep vein thrombosis
  • PE pulmonary embolism
  • IVC filter may be placed in the circulatory system to intercept one or more clots and prevent them from entering the lungs. IVC filters are either permanent or retrievable.
  • IVC filters there are many different configurations for IVC filters, including those that include a central hub from which extend a plurality of struts that form filter baskets having a conical configuration, such as disclosed in U.S. Patent No. 6,258,026, which is incorporated by reference in its entirety into this application.
  • Other IVC filter configurations utilize wires and/or frame members to form straining devices that permit flow of blood while trapping larger particles.
  • IVC filters are generally configured for compression into a small size to facilitate delivery into the inferior vena cava and subsequent expansion into contact with the inner wall thereof The IVC filter may later be retrieved from the deployed site by compressing the legs, frame members, etc., depending on the filter configuration.
  • an IVC filter will include hooks or anchoring members for anchoring the filter in position within the inferior vena cava.
  • the hooks may be more elastic than the legs or frame members to permit the hooks to straighten in response to withdrawal forces, which facilitate withdrawal from the endothelium layer of the blood vessel without risk of significant injury to the vessel wall.
  • Applicants have recognized that it would be desirable to form an IVC filter from a tube, including removing portions from the tube to form various features of the IVC filter. Applicants have also recognized that it would be desirable to form an IVC filter from one or more tubes to increase the potential appendages and levels of filtration of the IVC filter. Thus, described herein are embodiments of an IVC filter formed from one or more tubes.
  • implantable medical devices including IVC filters, that are formed from one or more tubes are described herein.
  • a method of making an implantable medical device includes providing a generally tubular structure having an inner diameter and a wall thickness, removing portions of the tubular structure along predetermined lines to form a plurality of appendages, weakening at least one section in one or more of the appendages near a distal end thereof, and bending the distal end of at least the appendages containing the section.
  • a filter formed from a shape memory tube includes a plurality of legs having a distal end terminating in a pointed tip, a first section in the legs positioned adjacent the tip having a material strength less than a material strength of a second section proximal the first section, and a bent section distal the first section.
  • a filter in another embodiment, includes a body and a plurality of legs formed from a generally tubular structure, a proximal end of the body being defined by the generally tubular structure, having an opening with a cross-sectional area less than a cross-sectional area of a dangerous migrating blood clot, the legs extending radially outward from the body along a longitudinal axis, one or more of the legs having a distal end terminating in a pointed tip and being formed into a hook.
  • a method of making an implantable medical device includes providing a first generally tubular structure having an inner diameter and a second generally tubular structure having an outer diameter less than the inner diameter of the first tubular structure, removing portions of the first and second tubular structures along predetermined lines to form a plurality of first and second appendages, and nesting a proximal end of the second tubular structure within a proximal end of the first tubular structure.
  • a filter formed from shape memory tubes includes a first filter member including a first proximal end defined by a first shape memory tube with an inner diameter, and a plurality of first appendages extending from the first proximal end, a distal end of at least one of the first appendages terminating in a pointed tip, and a second filter member including a second proximal end defined by a second shape memory tube with an outer diameter less than the inner diameter of the first shape memory tube, and a plurality of second appendages extending from the second proximal end, the second proximal end nested within the first proximal end and connected thereto.
  • a method of filtering fluid includes flowing fluid, including particles of various cross-sectional areas, through a generally tubular member that simulates a blood vessel, positioning a filter in the tubular member about a central axis defined by the tubular member, and permitting particles having cross-sectional areas less than the cross-sectional area of a dangerous migrating blood clot to flow through the filter coincident with the central axis.
  • FIG. 1 is a side perspective view of one embodiment of a filter formed from a tube, following removal of portions of the tube.
  • FIG. 2 is a side perspective view of the filter of FIG. 1, following a secondary procedure.
  • FIGS. 3A-3C are enlarged views of the distal end of a filter appendage, showing different potential tip structures.
  • FIG. 4 is a side perspective view of another embodiment of a filter formed from a tube.
  • FIG. 5 is a front perspective view of another embodiment of a filter formed from a tube.
  • FIG. 6 is a perspective view of an embodiment of a filter formed from a tube.
  • FIG. 6A is a cross-sectional view of FIG. 6 along line 6A-6A.
  • FIG. 7 is a perspective view of an embodiment of a filter formed from two tubes.
  • FIG. 7A is a cross-sectional view of FIG. 7 along line IA-I A.
  • the filter embodiments described herein could be used for filter applications that do not involve placing a filter device in the inferior vena cava.
  • the filters described herein are not limited to IVC applications.
  • suture material means a material that is, or could be, used as a suture thread by a surgeon, including, for example, synthetic polymers, polyglycolic acid (PGA), polylactic acid (PLA), polydioxanone (PDS), polyglactin, nylon, polypropylene (prolene), silk, catgut, non-absorbable/non-biodegradable materials, and combinations thereof.
  • bio-resorbable includes a suitable biocompatible material, mixture of various biocompatible materials or partial components of biocompatible material being altered into other materials by an agent present in the environment (e.g., a biodegradable material that degrades via a suitable mechanism such as hydrolysis when placed in biological tissue); such materials being removed by cellular activity or incorporated into the cellular structure (i.e., bioresorption, bioresorping, bioabsorption, or bioresorbable), such materials being degraded by bulk or surface degradation (i.e., bioerosion such as, for example, a water insoluble polymer that turns water- soluble in contact with biological tissue or fluid), or such materials being altered by a combination of one or more of biodegradable, bioerodable or bioresorpable activity when placed in contact with biological tissue or fluid.
  • an agent present in the environment e.g., a biodegradable material that degrades via a suitable mechanism such as hydrolysis when placed in biological tissue
  • the term "tip” or “tip section” means a member configured to engage a blood vessel wall, including a barb, hook, anchor, etc., examples of which are provided in U.S. Patent No. 6,258,026, which is incorporated by reference in its entirety into this application.
  • the phrase “weakening a section” means making the section thinner, heat treating the section, cutting grooves into the section, etc.
  • the term “lower material strength” means either a lower modulus of elasticity or a lower ability to resist bending; however, the term “stiffness” does not imply a direct correlation with material strength in that a member or portion of a medical device with a relatively lower material strength may achieve a relatively higher stiffness based on its physical geometry.
  • the term “dangerous migrating blood clot” is defined herein as a blood clot that is considered to be dangerous by a clinician skilled in the area of filter technology for a particular patient based on the patient's age, general state of health, cardiopulmonary reserve, etc.
  • the term “tube” means a generally tubular structure, having a lumen, an inner diameter, a wall thickness and a length.
  • Possible materials for the tube and filter described herein include a suitable biocompatible material such as, for example, stainless steel, noble metals and their alloys, shape memory metals, shape memory alloys, super elastic metal, linear elastic shape memory metal, metal alloys, shape memory polymers, polymers, bio-resorbable materials (e.g., metal alloys such as those shown and described in U.S. Patent No. 6,287,332; and U.S. Patent Application Publication No. 2002/0004060, each of which is incorporated by reference in its entirety into this application), and combinations thereof.
  • a suitable biocompatible material such as, for example, stainless steel, noble metals and their alloys, shape memory metals, shape memory alloys, super elastic metal, linear elastic shape memory metal, metal alloys, shape memory polymers, polymers, bio-resorbable materials (e.g., metal alloys such as those shown and described in U.S. Patent No. 6,287,332; and U.S. Patent Application Publication No. 2002/0004060, each of which is incorporated
  • bio-active agents can be coated to a portion or the entirety of the filter for controlled release of the agents once the filter is implanted.
  • the bio-active agents can include, but are not limited to, vasodilator, anti-coagulants, such as, for example, warfarin and heparin.
  • Other bio-active agents can include, but are not limited to, agents such as, for example, anti-proliferative/antimitotic agents including natural products such as vinca alkaloids (i.e. vinblastine, vincristine, and vinorelbine), paclitaxel, epidipodophyllotoxins (i.e.
  • antibiotics dactinomycin (actinomycin D) daunorubicin, doxorubicin and idarubicin
  • anthracyclines mitoxantrone, bleomycins, plicamycin (mithramycin) and mitomycin
  • enzymes L-asparaginase which systemically metabolizes L-asparagine and deprives cells which do not have the capacity to synthesize their own asparagine
  • antiplatelet agents such as G(GP) II b /III a inhibitors and vitronectin receptor antagonists
  • antiproliferative/antimitotic alkylating agents such as nitrogen mustards (mechlorethamine, cyclophosphamide and analogs, melphalan, chlorambucil), ethylenimines and methylmelamines (hexamethylmelamine and thiotepa), alkyl sulfonates-busulfan,
  • anti-coagulants heparin, synthetic heparin salts and other inhibitors of thrombin
  • fibrinolytic agents such as tissue plasminogen activator, streptokinase and urokinase), aspirin, dipyridamole, ticlopidine, clopidogrel, abciximab
  • antimigratory antisecretory (breveldin)
  • anti-inflammatory such as adrenocortical steroids (Cortisol, cortisone, fludrocortisone, prednisone, prednisolone, 6a- methylprednisolone, triamcinolone, betamethasone, and dexamethasone), non-steroidal agents (salicylic acid derivatives i.e.
  • a filter 10 is shown, formed from a tube 12.
  • the tube 12 can be of any of the materials discussed above, but in a preferred embodiment, the tube 12 is made of Nitinol.
  • the tube 12 has an inner diameter Di, a wall thickness Ti and a length Li.
  • the inner diameter Dj is in the range of approximately less than 5 millimeters to approximately 20 millimeters
  • the wall thickness Ti is in the range of approximately 100 microns to approximately 0.5 millimeters
  • the length Li is in the range of approximately 30 millimeters to approximately 60 millimeters.
  • the tube 12 is cut by a suitable technique, such as, for example, using chemical etching, photo etching, electrodischarge machining, or via a laser, along predetermined lines or patterns to form features of the filter, such as appendages, retrieval members, etc.
  • the predetermined lines or patterns outline legs 16 and an aperture 14 that forms a retrieval member.
  • the legs 16 can be of potentially greater variation in size and shape, which is believed to be a benefit of forming a filter from a tube, due to the fact that problems inherent with the manufacture of different sizes of appendages and subsequent attachment to a hub or body are avoided.
  • the appendages can have a greater thickness than width.
  • forming a filter from a tube is believed to facilitate manufacture of the filter because, for example, fewer steps may be necessary.
  • portions are removed so that the predetermined filter configuration remains, including legs 16 and body 18, as shown.
  • one or more secondary procedures may be implemented.
  • One potential secondary procedure involves weakening a section of one or more of the appendages of a filter.
  • the legs 16 are formed with a pointed tip section at the distal end thereof.
  • a weakening procedure is performed in which a section proximal the tip section is thinned, removed, grooved, heated, etc. in order to lower material strength of the section such that bending the tip section is facilitated (see, e.g., FIGS. 3A-3C).
  • the bent tip section can form a hook for engagement of a blood vessel wall, such as shown in FIG. 2.
  • Weakening procedures can also be performed on areas of the filter other than the tip section of an appendage.
  • One suitable technique may include the provision of sacrificial portions of the filter that can be removed prior to surface finishing the filter.
  • Another potential secondary procedure involves treating, such as heat setting, certain features of the filter to form the features into a desired configuration. For instance, in the embodiment shown in FIG. 2, the legs 16 are treated to extend radially outward from the body 18 along a longitudinal axis I 2 .
  • Other potential secondary procedures include, for example, heat setting the filter in a collapsed or expanded configuration, heat treating sections of the filter, performing surface treatments on sections of the filter, performing chemical treatments on sections of the filter, and coating one or more surfaces of the filter with one or more bio-active agents.
  • a bio-active agent is disposed on an inner surface of the filter.
  • the bio-active agent may be an anti-coagulant or antiproliferative agent.
  • the anti-coagulant agent may be released into the blood stream via various mechanisms, as known to one skilled in the art, upon implantation and deployment of the filter in a blood vessel.
  • suitable anti-coagulant agents are heparin, warafin and their analogs.
  • suitable anti -proliferative agents are rapamycin and its analogs.
  • filter 10 has a proximal end defined by the tube 12 including opening 17, which in this embodiment has approximately the same inner diameter as the tube 12.
  • the proximal end opening 17 permits passage of blood and relatively smaller emboli through the body 18 of the filter 10, but captures relatively larger emboli that may be considered by a clinician to be a dangerous migrating blood clot.
  • the filter 10 acts to reduce the size of the dangerous migrating blood clot through clot degradation, which can occur, for example, due to the erosive effect of the flow of blood thereover and/or the reductive effect produced by a bio-active agent coating on a surface of the filter.
  • a significant advantage over filters with a central hub is realized as a central opening is provided to improve flow characteristics of the blood over and through the filter.
  • improved performance characteristics may be realized, such as improved stress distribution, a smaller collapsed configuration for delivery (decreased profile), increased radial strength, increased migration resistance, and so on.
  • the appendages of a filter formed from a tube will have generally rectangular cross-sections as opposed to the circular cross-sections of appendages formed by wires or the like.
  • appendages of generally circular cross-section can be formed via a surface shaping process such as, for example, grinding, polishing or electropolishing.
  • the filter 10 is illustrated in an expanded configuration, defining an expanded perimeter.
  • the filter 10 For delivery of the filter 10 to a blood vessel, the filter 10 is compressed to a collapsed configuration, defining a collapsed perimeter smaller than the expanded perimeter.
  • the filter 10 can be self-expanding due an intrinsic characteristic, in which case deployment may involve simply removal of a constraining force or exposing the filter to an elevated temperature (e.g., for a filter employing a temperature sensitive material), or alternatively can require a separate expansion agent (e.g., balloon) for expansion. It should be appreciated that while the filter 10 may be of the self-expanding variety, a separate expansion agent may also be utilized for deployment within a blood vessel.
  • FIGS. 3A-3C illustrate examples of possible tip sections for legs 16.
  • FIG. 3A shows leg 16 with a shaft section 20 and a tip section 22 that tapers to a point.
  • the leg 16 also includes a slit 24 cut through the leg 16 to facilitate bending the tip section distal the slit 24, as discussed above, in order to form an anchoring member or hook.
  • FIG. 3B shows leg 16 with a tip section 23 that includes an aperture 26 which may provide certain advantages, including facilitation of bending with respect to the shaft section 20, also to provide an anchoring member or hook.
  • FIG. 3A shows leg 16 with a shaft section 20 and a tip section 22 that tapers to a point.
  • the leg 16 also includes a slit 24 cut through the leg 16 to facilitate bending the tip section distal the slit 24, as discussed above, in order to form an anchoring member or hook.
  • FIG. 3B shows leg 16 with a tip section 23 that includes an aperture 26 which may provide certain advantages, including facilitation of bending with respect to the shaft
  • the tip section 25 includes a reduced width section 28 that tapers to a point, the reduced width section 28 having a proximal end attached to a distal end of the shaft section 20 such that a shoulder 27 is formed.
  • the shoulder 27 is shown forming a 90 degree angle with respect to an edge of the shaft section 20, other embodiments of the shoulder 27 form an angle that is other than 90 degrees, such as, for example, an angled shoulder that connects an edge of the shaft section 20 to the reduced width section 28, an angled shoulder that connects the edges of the shaft section 20 to an intermediary shoulder, etc.
  • the shoulders 27 on each side of the reduced width section 28 are shown to be generally similar, other embodiments may include dissimilar shoulders 27.
  • the reduced width section 28 may be angled with respect to the shaft section 20 to provide an anchoring member or hook for the filter.
  • the weakening processes described in connection with FIGS. 3A-3C are believed to facilitate formation of hooks at the distal end of the legs 16, which are configured for engaging the wall of the blood vessel into which the filter 10 can be deployed. Removal from an IVC wall of a filter including hooks formed by one or more weakening procedure is believed to be facilitated and the IVC wall less prone to tearing.
  • hooks may be separately formed and attached to the end of legs
  • the hook contains a linear portion connected to an arcuate portion that terminates in a point, as shown and described in U.S. Patent No. 6,258,026.
  • the arcuate member has a cross- sectional area smaller than the cross-sectional area of the linear portion, as shown and described in U.S. Patent No. 6,258,026. Details of potential hooks for attachment to legs 16 are shown and described in U.S. Patent Application No. 11/429,975, filed May 9, 2006, claiming priority to U.S. Provisional Patent Application No.
  • Filter 30 includes appendages (i.e., legs 32 and arms 34) extending from a body 36, having an opening 38 at a proximal end thereof.
  • the legs 32 include a shaft section 40 and a tip section 42, which may be configured according to the embodiments discussed herein (for example, the embodiments illustrated in FIGS. 3A-3C).
  • the legs 32 and arms 34 can be of varying shapes and sizes or of substantially the same shape and size. As shown in FIG.
  • the legs 32 and arms 34 are processed in a secondary procedure to extend the appendages radially outward from the body along a longitudinal axis I 4 .
  • This is the expanded configuration of filter 30, which defines an expanded perimeter thereof.
  • the filter 30 is compressed to a collapsed configuration defining a collapsed perimeter smaller than the expanded perimeter.
  • the arms 34 in this embodiment are shorter in length than the legs 32 (but do not have to be) and extend first outwardly with respect to a longitudinal axis I 4 and then distally with respect to the proximal opening 38.
  • the arms 34 may provide a centering function to the filter 30 and, although shown in this embodiment without hooks or vessel- engaging members on their distal ends, may include hooks in other embodiments.
  • the legs 32 of the filter 30 extend angularly or arcuately with respect to the longitudinal axis I 4 and include a junction near a distal end thereof at which point the legs 32 diverge at a greater angle from the longitudinal axis I 4 , terminating in a pointed tip section 42 that may be formed into a hook.
  • the filter 30 contains six legs 32 and six arms 34.
  • one or more of the legs 32 and one or more of the arms 34 may include a hook at a distal end thereof.
  • a hook may also be positioned along the length of one or more of the legs 32, and/or one or more of the arms 34 to provide an engaging member for engaging the wall of a blood vessel.
  • filter 50 includes a retrieval member 56 that can be either formed from the tube or attached in a secondary procedure by methods known to one skilled in the art.
  • Filter 50 also includes a first level of filtration formed by legs 52 and a second level of filtration formed by arms 54. The first and second levels of filtration are formed by removing portions of a tube, such as portions whose excision results in openings 53.
  • the legs 52 and arms 54 forming the first and second levels of filtration, respectively, are shown with hooks 58 that can be formed through secondary processing, either through a weakening process coupled with a bending process or by separate attachment, as discussed above.
  • the retrieval member 56 has a hook- like configuration in this embodiment, but could alternatively be embodied by an aperture in a side of a proximal section of the filter 50, as discussed in connection with FIGS. 1-2.
  • a recovery device engages the retrieval member 56 and pulls the filter 50 into a recovery catheter, whereby the recovery catheter forces the appendages to compress to a filter collapsed configuration. In certain embodiments, this retraction of the filter 50 forces the hooks 58 to distort toward a straightened configuration, allowing for separation of the hooks 58 from the blood vessel wall.
  • FIGS. 6-7 illustrate an embodiment of a filter formed from two tubes.
  • a first filter member 60 is formed from a first tube, as shown in FIG. 6, the first filter member 60 including appendages 62 terminating in pointed tip sections 64 and a proximal end 66 defined by the tube from which it is formed, having a proximal opening 68, as shown in FIG. 6A.
  • the pointed tip sections 64 can be formed into hooks as described herein in a secondary process.
  • one or more appendages may include non-pointed tip sections and/or tip sections that are initially formed into a desired configuration.
  • a filter 80 includes the first filter member 60 and a second filter member 70.
  • the second filter member 70 includes appendages 72 with tip sections 74, shown here in a pointed configuration. However, in other embodiments, one or more of the appendages of the second filter member 70 are blunt or non-pointed in configuration.
  • the second filter member 70 also includes a proximal end 76 that is defined by the tube from which it is formed, having a proximal opening 78, as shown in FIG. 7A.
  • the combined thickness of the first and second tubes is in the range of approximately 0.1 millimeters to approximately 2 millimeters.
  • the proximal end 76 of the second filter member 70 is nested within the proximal end 66 of the first filter member 60 and attached thereto by methods known to one skilled in the art (e.g., adhesive bonding, solvent bonding, mechanical connection, welding, brazing, crimping, etc.).
  • the outer diameter of the second filter member proximal end 76 is less than the inner diameter of the first filter member proximal end 66 to permit the nesting; however, the outer diameter of the proximal end 76 may be only slightly less than the inner diameter of the proximal end 66 in order to provide a tight fit between the first and second filter members.
  • the inner diameter of the proximal end 76 is approximately 0.5 millimeters, the inner diameter of the proximal end 66 is approximately 1.25 millimeters and the outer diameter of the proximal end 66 is approximately 2 millimeters.
  • the proximal end 82 of the filter 80 may include an aperture that forms a retrieval member, such as aperture 14 in FIG. 1, or may include a different type of retrieval member positioned proximal of the appendages 62, 72. [0040] In the embodiment shown in FIG.
  • the appendages 62 of the first filter member 60 are longer than the appendages 72 of the second filter member 70 such that the first filter member appendages 62 form a first level of filtration and the second filter member appendages 72 form a second level of filtration at a position along the filter 80 different from the first level of filtration.
  • one of the first or second filter member appendages 62, 72 may provide the filter 80 with a self-centering capability.
  • the appendages 62, 72 may be similar in length or the appendages 72 may be longer than the appendages 62.
  • the appendages 62, 72 are formed by removing portions of a first and second tube and can be further formed into hooks through secondary processing, such as that described above.
  • the filter 80 due to the nested configuration, includes a greater number of appendages or struts than is possible in a single filter member formed from a tube. This permits additional levels of filtering and/or centering as discussed, and provides a smaller filter diameter than a filter with a similar number of appendages, as an increase in the diameter of the tube is necessary to increase the number of appendages. As is appreciated by one skilled in the art, a smaller profile facilitates delivery of the filter to a blood vessel.
  • FIG. 7 illustrates a preferred embodiment of two nested filter members, in other embodiments three or more filter members could be nested to form a filter.
  • Each of the filter embodiments discussed herein can also include one or more filaments attached thereto.
  • the filaments are made of suture material, although in other embodiments, the filaments are made of a bio-resorbable material or any of the materials discussed above with respect to possible materials for the filter.
  • the filaments could be attached to the body, one or more of the appendages of the filter, or a combination thereof.
  • the filaments may be attached to the filter by wrapping the filament one or more times around an attachment location on the filter, tying the filament to an attachment location on the filter, heating the filament adjacent to an attachment location on the filter to create a bond therebetween, applying an adhesive to the filament and/or an attachment location on the filter, applying a solvent to the filament and/or an attachment location on the filter, etc.
  • This invention has been described and specific examples of the invention have been portrayed. While the invention has been described in terms of particular variations and illustrative figures, those of ordinary skill in the art will recognize that the invention is not limited to the variations or figures described.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un filtre formé à partir d'un tube. Ce filtre peut être formé à partir d'un ou plusieurs tubes. Il peut comprendre un premier et un deuxième éléments de filtre formés respectivement à partir d'un premier et d'un deuxième tubes, le deuxième élément de filtre ayant une extrémité proximale logée dans l'extrémité proximale du premier élément de filtre. Le filtre peut comprendre des appendices ayant une section de bout qui se termine en pointe. L'extrémité proximale du filtre peut être définie par une ouverture configurée de façon à empêcher des emboles de taille relativement grande de franchir le filtre.
PCT/US2007/006003 2006-03-14 2007-03-08 Filtre pour veine cave formé à partir d'un tube Ceased WO2007106378A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78201906P 2006-03-14 2006-03-14
US60/782,019 2006-03-14
US83170506P 2006-07-18 2006-07-18
US60/831,705 2006-07-18

Publications (2)

Publication Number Publication Date
WO2007106378A2 true WO2007106378A2 (fr) 2007-09-20
WO2007106378A3 WO2007106378A3 (fr) 2008-01-31

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Family Applications (1)

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PCT/US2007/006003 Ceased WO2007106378A2 (fr) 2006-03-14 2007-03-08 Filtre pour veine cave formé à partir d'un tube

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WO (1) WO2007106378A2 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014703A1 (fr) 2009-07-29 2011-02-03 C.R. Bard, Inc. Filtre tubulaire
US7967838B2 (en) 2005-05-12 2011-06-28 C. R. Bard, Inc. Removable embolus blood clot filter
US8062327B2 (en) 2005-08-09 2011-11-22 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US8133251B2 (en) 1998-09-25 2012-03-13 C.R. Bard, Inc. Removeable embolus blood clot filter and filter delivery unit
US8372109B2 (en) 2004-08-04 2013-02-12 C. R. Bard, Inc. Non-entangling vena cava filter
US9131999B2 (en) 2005-11-18 2015-09-15 C.R. Bard Inc. Vena cava filter with filament
GB2524289A (en) * 2014-03-19 2015-09-23 Cook Medical Technologies Llc Vascular filter
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US9326842B2 (en) 2006-06-05 2016-05-03 C. R . Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
WO2023129175A1 (fr) * 2021-12-30 2023-07-06 Bard Peripheral Vascular, Inc. Implant vasculaire
WO2023129178A1 (fr) * 2021-12-30 2023-07-06 Bard Peripheral Vascular, Inc. Implant vasculaire
US12115057B2 (en) 2005-05-12 2024-10-15 C.R. Bard, Inc. Tubular filter

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US20040073252A1 (en) * 2001-02-20 2004-04-15 Mark Goldberg Blood clot filtering system
US6585753B2 (en) * 2001-03-28 2003-07-01 Scimed Life Systems, Inc. Expandable coil stent
US7344550B2 (en) * 2003-10-21 2008-03-18 Boston Scientific Scimed, Inc. Clot removal device
US7722635B2 (en) * 2004-06-25 2010-05-25 Angiodynamics, Inc. Blood clot filter
US7544202B2 (en) * 2004-06-25 2009-06-09 Angiodynamics, Inc. Retrievable blood clot filter
US7704267B2 (en) * 2004-08-04 2010-04-27 C. R. Bard, Inc. Non-entangling vena cava filter

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9351821B2 (en) 1998-09-25 2016-05-31 C. R. Bard, Inc. Removable embolus blood clot filter and filter delivery unit
US8690906B2 (en) 1998-09-25 2014-04-08 C.R. Bard, Inc. Removeable embolus blood clot filter and filter delivery unit
US8133251B2 (en) 1998-09-25 2012-03-13 C.R. Bard, Inc. Removeable embolus blood clot filter and filter delivery unit
US9615909B2 (en) 1998-09-25 2017-04-11 C.R. Bard, Inc. Removable embolus blood clot filter and filter delivery unit
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US11103339B2 (en) 2004-08-04 2021-08-31 C. R. Bard, Inc. Non-entangling vena cava filter
US8372109B2 (en) 2004-08-04 2013-02-12 C. R. Bard, Inc. Non-entangling vena cava filter
US9144484B2 (en) 2004-08-04 2015-09-29 C. R. Bard, Inc. Non-entangling vena cava filter
US8628556B2 (en) 2004-08-04 2014-01-14 C. R. Bard, Inc. Non-entangling vena cava filter
US11730583B2 (en) 2005-05-12 2023-08-22 C.R. Band. Inc. Tubular filter
US9017367B2 (en) 2005-05-12 2015-04-28 C. R. Bard, Inc. Tubular filter
US9498318B2 (en) 2005-05-12 2016-11-22 C.R. Bard, Inc. Removable embolus blood clot filter
US10813738B2 (en) 2005-05-12 2020-10-27 C.R. Bard, Inc. Tubular filter
US8613754B2 (en) 2005-05-12 2013-12-24 C. R. Bard, Inc. Tubular filter
US10729527B2 (en) 2005-05-12 2020-08-04 C.R. Bard, Inc. Removable embolus blood clot filter
US8574261B2 (en) 2005-05-12 2013-11-05 C. R. Bard, Inc. Removable embolus blood clot filter
US7967838B2 (en) 2005-05-12 2011-06-28 C. R. Bard, Inc. Removable embolus blood clot filter
US12115057B2 (en) 2005-05-12 2024-10-15 C.R. Bard, Inc. Tubular filter
US9387063B2 (en) 2005-08-09 2016-07-12 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US8062327B2 (en) 2005-08-09 2011-11-22 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US8430903B2 (en) 2005-08-09 2013-04-30 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US11517415B2 (en) 2005-08-09 2022-12-06 C.R. Bard, Inc. Embolus blood clot filter and delivery system
US10492898B2 (en) 2005-08-09 2019-12-03 C.R. Bard, Inc. Embolus blood clot filter and delivery system
US10842608B2 (en) 2005-11-18 2020-11-24 C.R. Bard, Inc. Vena cava filter with filament
US12226302B2 (en) 2005-11-18 2025-02-18 C.R. Bard, Inc. Vena cava filter with filament
US9131999B2 (en) 2005-11-18 2015-09-15 C.R. Bard Inc. Vena cava filter with filament
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
US10980626B2 (en) 2006-05-02 2021-04-20 C. R. Bard, Inc. Vena cava filter formed from a sheet
US11141257B2 (en) 2006-06-05 2021-10-12 C. R. Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US9326842B2 (en) 2006-06-05 2016-05-03 C. R . Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
WO2011014703A1 (fr) 2009-07-29 2011-02-03 C.R. Bard, Inc. Filtre tubulaire
EP3505136A1 (fr) 2009-07-29 2019-07-03 C.R. Bard Inc. Filtre tubulaire
GB2524289A (en) * 2014-03-19 2015-09-23 Cook Medical Technologies Llc Vascular filter
EP2926768A1 (fr) * 2014-03-19 2015-10-07 Cook Medical Technologies LLC Filtre vasculaire
US9788932B2 (en) 2014-03-19 2017-10-17 Cook Medical Technologies Llc Vascular filter
GB2524289B (en) * 2014-03-19 2016-03-09 Cook Medical Technologies Llc Vascular filter
WO2023129175A1 (fr) * 2021-12-30 2023-07-06 Bard Peripheral Vascular, Inc. Implant vasculaire
WO2023129178A1 (fr) * 2021-12-30 2023-07-06 Bard Peripheral Vascular, Inc. Implant vasculaire

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