[go: up one dir, main page]

WO2007104724A3 - Identification of osteoblast cells differentiation and bone tumor markers and uses thereof - Google Patents

Identification of osteoblast cells differentiation and bone tumor markers and uses thereof Download PDF

Info

Publication number
WO2007104724A3
WO2007104724A3 PCT/EP2007/052253 EP2007052253W WO2007104724A3 WO 2007104724 A3 WO2007104724 A3 WO 2007104724A3 EP 2007052253 W EP2007052253 W EP 2007052253W WO 2007104724 A3 WO2007104724 A3 WO 2007104724A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
bone tumor
tumor markers
bone
osteoblast cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/052253
Other languages
French (fr)
Other versions
WO2007104724A2 (en
Inventor
Annalisa Santucci
Adriano Spreafico
Bruno Frediani
Roberto Marcolongo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Siena
Original Assignee
Universita degli Studi di Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Siena filed Critical Universita degli Studi di Siena
Publication of WO2007104724A2 publication Critical patent/WO2007104724A2/en
Publication of WO2007104724A3 publication Critical patent/WO2007104724A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4718—Lipocortins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention discloses a method for the diagnosis of a metabolic bone disease, and/or for assessing osteoporotic fracture risk and/or for the monitoring of therapeutic efficacy of a metabolic bone disease drug in a subject and a method for the diagnosis of bone tumor including the identification and quantification of bone cell or bone tumor specific proteins.
PCT/EP2007/052253 2006-03-10 2007-03-09 Identification of osteoblast cells differentiation and bone tumor markers and uses thereof Ceased WO2007104724A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78194706P 2006-03-10 2006-03-10
US60/781,947 2006-03-10

Publications (2)

Publication Number Publication Date
WO2007104724A2 WO2007104724A2 (en) 2007-09-20
WO2007104724A3 true WO2007104724A3 (en) 2007-11-08

Family

ID=38175809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/052253 Ceased WO2007104724A2 (en) 2006-03-10 2007-03-09 Identification of osteoblast cells differentiation and bone tumor markers and uses thereof

Country Status (1)

Country Link
WO (1) WO2007104724A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2396424A1 (en) * 2009-02-10 2011-12-21 INSERM - Institut National de la Santé et de la Recherche Médicale Galectin-1 (gal1) as a biomarker for differential diagnosis of osteosarcoma and chondrosarcoma
FR2953023B1 (en) * 2009-11-23 2011-12-09 Commissariat Energie Atomique USE OF AN ISOFORM OF HLA-G AS A MARKER OF OSTEOGENESIS
CN113308537A (en) * 2021-06-23 2021-08-27 徐文停 Application of serum galectin-1 as bone metabolism marker in osteoporosis diagnosis
CN114306618B (en) * 2022-01-14 2024-03-29 中山大学 Application of a polyester amide compound in the preparation of drugs for preventing and/or treating blood system diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076730A1 (en) * 1995-06-07 2002-06-20 Co.Don Aktiengesellschaft Methods for Identifying Potential Therapeutic Agents for Treatment of Osteoporosis Using Mitogenic Indices

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076730A1 (en) * 1995-06-07 2002-06-20 Co.Don Aktiengesellschaft Methods for Identifying Potential Therapeutic Agents for Treatment of Osteoporosis Using Mitogenic Indices

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANKERSEN L ET AL: "AGING OF HUMAN TRABECULAR OSTEOBLASTS IN CULTURE", ARCHIVES OF GERONTOLOGY AND GERIATRICS, ELSEVIER, AMSTERDAM, NL, no. SUPPL 4, January 1994 (1994-01-01), pages 5 - 12, XP000605183, ISSN: 0167-4943 *
SCHALLER S ET AL: "In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?", ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 3, no. 5, October 2005 (2005-10-01), pages 553 - 580, XP002425954, ISSN: 1540-658X *
SPREAFICO ADRIANO ET AL: "Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis.", JOURNAL OF CELLULAR BIOCHEMISTRY 1 JUL 2006, vol. 98, no. 4, 14 February 2006 (2006-02-14), pages 1007 - 1020, XP002439813, ISSN: 0730-2312 *

Also Published As

Publication number Publication date
WO2007104724A2 (en) 2007-09-20

Similar Documents

Publication Publication Date Title
EP2503338A3 (en) CD73 as a biomarker for monitoring development of diseases and assessing the efficacy of therapies
WO2008146309A3 (en) Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
WO2005114190A3 (en) Methods of identifying biomarkers
WO2010118035A3 (en) Biomarkers for monitoring treatment of neuropsychiatric diseases
WO2009100137A3 (en) Magnetic cells for localizing delivery and tissue repair
WO2008030273A3 (en) Compositions and methods for diagnosis and treatment of type 2 diabetes
WO2008008483A3 (en) Dendrimer based compositions and methods of using the same
WO2007092433A3 (en) Osteoporosis associated markers and methods of use thereof
WO2006119467A3 (en) Protein activity modification
WO2009009203A3 (en) Dendrimer based compositions and methods of using the same
WO2008103920A3 (en) Targeted protein cages
WO2011002834A3 (en) Compositions and methods for diagnosis and treatment of type 1 diabetes
WO2008127388A3 (en) Use of quantum system identification and quantum control techniques for medical diagnostic and therapeutic purposes
WO2008070663A3 (en) Companion diagnostic assays for cancer therapy
AU2007304320A1 (en) Method for sampling biological tissue for the identification of animals
EP2857522A3 (en) Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof including gender-based disease identification, assessment, prevention and therapy
WO2007104724A3 (en) Identification of osteoblast cells differentiation and bone tumor markers and uses thereof
WO2007109733A3 (en) Diagnostic and prognostic markers and treatment strategies for multiple sclerosis
WO2005085860A3 (en) New proliferation markers in clinical practice and their use for cancer prognosis or diagnosis
EP2738265A3 (en) MHC genes and risk of graft versus host disease
WO2007094027A3 (en) Methods for the diagnosis of proliferative and/or conformational diseases
GB0507838D0 (en) A method of measuring the glomerular filtration rate of an human or animal patient, a self-use kit for providing blood samples for use in measuring glomerular
EP1968659A4 (en) BIOLOGICAL SURGICAL PATCH AND METHOD FOR PRODUCING THE SAME
WO2010033951A3 (en) Methods for identification and prediction of multiple sclerosis disease and therapy response
WO2008055225A3 (en) Systems and methods for in vivo measurement of interstitial biological activity, processes and/or compositions

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07726770

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07726770

Country of ref document: EP

Kind code of ref document: A2