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WO2007103763A3 - Methods for generating and using stem cell profiles - Google Patents

Methods for generating and using stem cell profiles Download PDF

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Publication number
WO2007103763A3
WO2007103763A3 PCT/US2007/063123 US2007063123W WO2007103763A3 WO 2007103763 A3 WO2007103763 A3 WO 2007103763A3 US 2007063123 W US2007063123 W US 2007063123W WO 2007103763 A3 WO2007103763 A3 WO 2007103763A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem
cell
cells
profiles
individuals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/063123
Other languages
French (fr)
Other versions
WO2007103763A2 (en
Inventor
Ami Treves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Regenerate Inc
Original Assignee
Bio Regenerate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Regenerate Inc filed Critical Bio Regenerate Inc
Publication of WO2007103763A2 publication Critical patent/WO2007103763A2/en
Publication of WO2007103763A3 publication Critical patent/WO2007103763A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method for phenotypical and functional characterization of various populations of stem and progenitor cells from cell samples, such as tissue samples is disclosed. In one aspect, the method can be used to identify the status of these cells and their functions in individuals. The method, when applied to blood tissue, can include a step of enriching stem cell lineages that are commonly found in both the bone marrow and peripheral blood: the hematopoietic, endothelial and mesenchymal stem/progenitor cells. The variety and population of stem cells can be identified by analysis of cell markers for several defined stem cell and lineage committed markers and by analysis of characteristic ex vivo self renewal potential. Such techniques can be used to obtain a functional profile of stem/progenitor populations for each cell sample, and for various clinical conditions. The profile can also be associated with and add value to the storage and banking business of stem cells. Profiles and consecutive profiles for individuals can be included in a database along with health characteristics of the individuals. The database can be used for patient follow-up or scientific reference. Database profiles for certain populations may serve for statistical, epidemiological and health evaluations.
PCT/US2007/063123 2006-03-06 2007-03-02 Methods for generating and using stem cell profiles Ceased WO2007103763A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77999306P 2006-03-06 2006-03-06
US60/779,993 2006-03-06

Publications (2)

Publication Number Publication Date
WO2007103763A2 WO2007103763A2 (en) 2007-09-13
WO2007103763A3 true WO2007103763A3 (en) 2008-07-10

Family

ID=38475707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/063123 Ceased WO2007103763A2 (en) 2006-03-06 2007-03-02 Methods for generating and using stem cell profiles

Country Status (1)

Country Link
WO (1) WO2007103763A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109897815B (en) * 2019-02-20 2021-04-16 北京京蒙高科干细胞技术有限公司 Efficient separation and culture method of adipose endothelial progenitor cells without coating

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142457A1 (en) * 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US20050208025A1 (en) * 2002-04-16 2005-09-22 Fleming William H Enhancement of hematopoietic stem cell survival
US20050266556A1 (en) * 2004-02-09 2005-12-01 Yoder Mervin C Isolation, expansion and use of clonogenic endothelial progenitor cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142457A1 (en) * 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US20050208025A1 (en) * 2002-04-16 2005-09-22 Fleming William H Enhancement of hematopoietic stem cell survival
US20050266556A1 (en) * 2004-02-09 2005-12-01 Yoder Mervin C Isolation, expansion and use of clonogenic endothelial progenitor cells

Also Published As

Publication number Publication date
WO2007103763A2 (en) 2007-09-13

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