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WO2007146890A3 - Préparation et utilisations de pyrazoles substitués actifs vis-à-vis des récepteurs cannabinoïdes - Google Patents

Préparation et utilisations de pyrazoles substitués actifs vis-à-vis des récepteurs cannabinoïdes Download PDF

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Publication number
WO2007146890A3
WO2007146890A3 PCT/US2007/070905 US2007070905W WO2007146890A3 WO 2007146890 A3 WO2007146890 A3 WO 2007146890A3 US 2007070905 W US2007070905 W US 2007070905W WO 2007146890 A3 WO2007146890 A3 WO 2007146890A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorder
cannabinoid receptor
preparation
utility
receptor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/070905
Other languages
English (en)
Other versions
WO2007146890A2 (fr
Inventor
Thomas G Gant
Sepehr Sarshar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auspex Pharmaceuticals Inc
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of WO2007146890A2 publication Critical patent/WO2007146890A2/fr
Publication of WO2007146890A3 publication Critical patent/WO2007146890A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des modulateurs des récepteurs de type CB-I ainsi que les sels et les promédicaments de qualité pharmaceutique desdits modulateurs, leur synthèse chimique et leur utilisation médicale dans le traitement et/ou la gestion de la gravité et de la durée de l'obésité, du syndrome métabolique, de la dyslipidémie, d'un déséquilibre de glucose, de l'incapacité à conserver une perte de poids, de l'insulinorésistance, d'un trouble cardio-vasculaire, d'une perte de mémoire, d'une dépendance à une drogue, d'un trouble dépressif, d'un trouble de type panique, d'un trouble obsessionnel compulsif, de l'anxiété, du syndrome de stress post-traumatique, et de tout autre état pathologique pour lequel il est avantageux d'inhiber, de présenter un agoniste inverse ou de moduler un récepteur cannabinoïde. Formule 1
PCT/US2007/070905 2006-06-09 2007-06-11 Préparation et utilisations de pyrazoles substitués actifs vis-à-vis des récepteurs cannabinoïdes Ceased WO2007146890A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81227606P 2006-06-09 2006-06-09
US60/812,276 2006-06-09
US84020506P 2006-08-25 2006-08-25
US60/840,205 2006-08-25

Publications (2)

Publication Number Publication Date
WO2007146890A2 WO2007146890A2 (fr) 2007-12-21
WO2007146890A3 true WO2007146890A3 (fr) 2008-03-06

Family

ID=38832758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070905 Ceased WO2007146890A2 (fr) 2006-06-09 2007-06-11 Préparation et utilisations de pyrazoles substitués actifs vis-à-vis des récepteurs cannabinoïdes

Country Status (1)

Country Link
WO (1) WO2007146890A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008062480A2 (fr) * 2006-11-24 2008-05-29 Ind-Swift Laboratories Limited Procédé amélioré de préparation du rimonabant
BRPI0916769A2 (pt) 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
RU2568896C2 (ru) * 2013-07-31 2015-11-20 Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" Лекарственное средство на основе вещества, влияющего на эндоканнабиноидную систему
CN105111084A (zh) * 2015-09-07 2015-12-02 台州学院 一种4-取代-3-甲基-2，4-二氧代丁酸酯的合成方法
MX2022015613A (es) 2020-06-08 2023-04-04 Tactogen Inc Composiciones de benzofurano beneficiosas para trastornos mentales o mejoramiento mental.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058820A1 (en) * 2002-03-12 2004-03-25 Hagmann William K. Substituted amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058820A1 (en) * 2002-03-12 2004-03-25 Hagmann William K. Substituted amides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HONKAKOSKI ET AL.: "Regulation of cytochrome P450 (CYP) genes by nuclear receptors", BIOCHEM. J., vol. 347, 2000, pages 321 - 337 *
KUSHNER ET AL.: "Pharmacological uses and perspective of heavy water and deuterated compounds", CAN. J. PHYSIOL. PHARMACOL., vol. 77, 1999, pages 79 - 88 *
THAKUR ET AL.: "CB1 Cannabinoid Receptor Ligands", MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 5, no. 7, 2005, pages 631 - 640 *

Also Published As

Publication number Publication date
WO2007146890A2 (fr) 2007-12-21

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