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WO2007144394A3 - Pharmaceutical use of substituted piperidine carboxamides - Google Patents

Pharmaceutical use of substituted piperidine carboxamides Download PDF

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Publication number
WO2007144394A3
WO2007144394A3 PCT/EP2007/055865 EP2007055865W WO2007144394A3 WO 2007144394 A3 WO2007144394 A3 WO 2007144394A3 EP 2007055865 W EP2007055865 W EP 2007055865W WO 2007144394 A3 WO2007144394 A3 WO 2007144394A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical use
substituted piperidine
compounds
piperidine carboxamides
carboxamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/055865
Other languages
French (fr)
Other versions
WO2007144394A2 (en
Inventor
John Paul Kilburn
Gita Camilla Tejlgaard Kampen
Henrik Sune Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to EP07730147A priority Critical patent/EP2038255A2/en
Priority to US12/304,501 priority patent/US20090306048A1/en
Priority to JP2009514799A priority patent/JP2009539937A/en
Priority to CA002655282A priority patent/CA2655282A1/en
Publication of WO2007144394A2 publication Critical patent/WO2007144394A2/en
Publication of WO2007144394A3 publication Critical patent/WO2007144394A3/en
Priority to IL195273A priority patent/IL195273A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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Abstract

A novel class of compounds of the general formula (I) and (Ia), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β- hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.
PCT/EP2007/055865 2006-06-16 2007-06-14 Pharmaceutical use of substituted piperidine carboxamides Ceased WO2007144394A2 (en)

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EP07730147A EP2038255A2 (en) 2006-06-16 2007-06-14 Pharmaceutical use of substituted piperidine carboxamides
US12/304,501 US20090306048A1 (en) 2006-06-16 2007-06-14 Pharmaceutical use of substituted piperidine carboxamides
JP2009514799A JP2009539937A (en) 2006-06-16 2007-06-14 Pharmaceutical use of substituted piperidine carboxamides
CA002655282A CA2655282A1 (en) 2006-06-16 2007-06-14 Pharmaceutical use of substituted piperidine carboxamides
IL195273A IL195273A0 (en) 2006-06-16 2008-11-13 Pharmaceutical use of substituted piperidine carboxamides

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EP06115591.7 2006-06-16
EP06115591 2006-06-16

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WO2007144394A3 true WO2007144394A3 (en) 2008-04-10

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EP (1) EP2038255A2 (en)
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CA (1) CA2655282A1 (en)
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