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WO2007141805A3 - Novel process for the preparation of sildenafil citrate - Google Patents

Novel process for the preparation of sildenafil citrate Download PDF

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Publication number
WO2007141805A3
WO2007141805A3 PCT/IN2007/000219 IN2007000219W WO2007141805A3 WO 2007141805 A3 WO2007141805 A3 WO 2007141805A3 IN 2007000219 W IN2007000219 W IN 2007000219W WO 2007141805 A3 WO2007141805 A3 WO 2007141805A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
novel process
sildenafil citrate
methyl
sildenafil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000219
Other languages
French (fr)
Other versions
WO2007141805A2 (en
Inventor
Seeta Ramanjaneyulu Gorantla
Mohan Bhandari
Venkata Sunil Kumar Indukuri
Srinivas Simhadri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Priority to EP07805617A priority Critical patent/EP2024369A4/en
Publication of WO2007141805A2 publication Critical patent/WO2007141805A2/en
Publication of WO2007141805A3 publication Critical patent/WO2007141805A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed herein the process for producing 5-[2-ethoxy-5-(4-methyl)piperazine-l-yl- sulfonyl)phenyl]- 1 -methyl-3-n-propyl- 1 ,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one or its salt thereof employing novel intermediate.
PCT/IN2007/000219 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate Ceased WO2007141805A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07805617A EP2024369A4 (en) 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN960/CHE/2006 2006-06-05
IN960CH2006 2006-06-05

Publications (2)

Publication Number Publication Date
WO2007141805A2 WO2007141805A2 (en) 2007-12-13
WO2007141805A3 true WO2007141805A3 (en) 2008-02-21

Family

ID=38801906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000219 Ceased WO2007141805A2 (en) 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate

Country Status (2)

Country Link
EP (1) EP2024369A4 (en)
WO (1) WO2007141805A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI462739B (en) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Preparation and medical use of Sildenafil-homologous quaternary ammonium piperazine salt
AT512084A1 (en) 2011-10-20 2013-05-15 Univ Wien Tech DIAZABICYCLO AND DIAZASPIRO ALKAN DERIVATIVES AS PHOSPHODIESTERASE-5 INHIBITORS
CN102690273B (en) * 2012-06-07 2014-11-05 杭州奥默医药技术有限公司 Preparation method of sildenafil
CN103664961B (en) * 2013-12-18 2015-12-09 成都医路康医学技术服务有限公司 A kind of synthesis technique of Virga
CN103772394A (en) * 2014-03-04 2014-05-07 南京友杰医药科技有限公司 Synthesis method of ethyl-removed sildenafil
CN105777669B (en) * 2016-04-21 2018-03-20 锦州医科大学 The method that 2 ethyoxyl 5 (the base sulfonyl of 4 methyl piperazine 1) benzoic acid are prepared with gaultherolin
CN111116591A (en) * 2018-10-30 2020-05-08 天津科伦药物研究有限公司 Method for preparing sildenafil citrate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0994115A2 (en) * 1998-10-12 2000-04-19 Pfizer Limited Process for preparation of pyrazolo-(4,3-d)pyrimidin-7-ones and intermediates thereof
EP1129093A1 (en) * 1998-11-11 2001-09-05 Dong A Pharmaceutical Co. Ltd. Pyrazolopyrimidinone derivatives for the treatment of impotence
EP1400522A1 (en) * 2001-06-29 2004-03-24 Baoshun Liu New compounds for treating impotence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0994115A2 (en) * 1998-10-12 2000-04-19 Pfizer Limited Process for preparation of pyrazolo-(4,3-d)pyrimidin-7-ones and intermediates thereof
EP1129093A1 (en) * 1998-11-11 2001-09-05 Dong A Pharmaceutical Co. Ltd. Pyrazolopyrimidinone derivatives for the treatment of impotence
EP1400522A1 (en) * 2001-06-29 2004-03-24 Baoshun Liu New compounds for treating impotence

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2024369A4 *

Also Published As

Publication number Publication date
WO2007141805A2 (en) 2007-12-13
EP2024369A4 (en) 2010-10-27
EP2024369A2 (en) 2009-02-18

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