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WO2007141718A3 - Method and apparatus for providing samples of volatiles to analysis using a multi-port valve and cryo-modulation - Google Patents

Method and apparatus for providing samples of volatiles to analysis using a multi-port valve and cryo-modulation Download PDF

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Publication number
WO2007141718A3
WO2007141718A3 PCT/IB2007/052063 IB2007052063W WO2007141718A3 WO 2007141718 A3 WO2007141718 A3 WO 2007141718A3 IB 2007052063 W IB2007052063 W IB 2007052063W WO 2007141718 A3 WO2007141718 A3 WO 2007141718A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatiles
cryo
modulation
analysis
port valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/052063
Other languages
French (fr)
Other versions
WO2007141718A2 (en
Inventor
Olivier Haefliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich SA
Original Assignee
Firmenich SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich SA filed Critical Firmenich SA
Priority to EP07736065A priority Critical patent/EP2032965A2/en
Publication of WO2007141718A2 publication Critical patent/WO2007141718A2/en
Publication of WO2007141718A3 publication Critical patent/WO2007141718A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2226—Sampling from a closed space, e.g. food package, head space
    • G01N2001/2229—Headspace sampling, i.e. vapour over liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/202—Injection using a sampling valve rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The present invention is related to a sampling technique for volatiles and its use to concentrate and/or detect and/or separate chemical components of complex mixtures thereof that enable the automatic on-line sampling and real-time analysis of volatiles present at low concentrations, for example in the headspace. The method and apparatus according to the invention comprise loading means equipped with a multiport-valve and mobile cryo-modulation means.
PCT/IB2007/052063 2006-06-09 2007-06-01 Method and apparatus for providing samples of volatiles to analysis using a multi-port valve and cryo-modulation Ceased WO2007141718A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07736065A EP2032965A2 (en) 2006-06-09 2007-06-01 Method and apparatus for on-line monitoring of volatiles to analysis using a multi-port valve and cryo-modulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006051848 2006-06-09
IBPCT/IB2006/051848 2006-06-09

Publications (2)

Publication Number Publication Date
WO2007141718A2 WO2007141718A2 (en) 2007-12-13
WO2007141718A3 true WO2007141718A3 (en) 2008-02-14

Family

ID=38650087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/052063 Ceased WO2007141718A2 (en) 2006-06-09 2007-06-01 Method and apparatus for providing samples of volatiles to analysis using a multi-port valve and cryo-modulation

Country Status (2)

Country Link
EP (1) EP2032965A2 (en)
WO (1) WO2007141718A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9810675B2 (en) 2013-03-15 2017-11-07 The Regents Of The University Of California System and method for non-invasively and non-destructively authenticating bottled beverages
CN103344728B (en) * 2013-06-18 2014-10-15 华东师范大学 In-situ headspace sample injector
CN103604897B (en) * 2013-10-31 2014-12-03 陕西延长石油(集团)有限责任公司研究院 On-line multidimensional gas chromatographic analysis device universal for low carbon catalytic conversion reaction
CN104914198B (en) * 2014-03-11 2017-03-15 上海兰博贸易有限公司 Gas automatic sampling device and its using method
CN105784889B (en) * 2014-12-25 2018-11-30 中国科学院广州能源研究所 The quick analysis system and method for thick gas tar oil content
CN105891367B (en) * 2016-04-27 2018-06-15 中国烟草总公司郑州烟草研究院 A kind of gas-chromatography of essence spice for cigarette-quadrupole rod flight time mass spectrum/flame ion detection method
CN106226446B (en) * 2016-09-21 2018-01-30 贵州省环境科学研究设计院 A kind of gas-chromatography dilutes inlet duct
US10717056B1 (en) 2019-09-09 2020-07-21 Michael Cem Gokay Method and apparatus for purification of cannabinoid extracts
CN112002449B (en) * 2020-07-27 2024-09-10 中核武汉核电运行技术股份有限公司 Off-line vacuum sipping detection and safety control system and control method
CN112113810A (en) * 2020-08-11 2020-12-22 中国原子能科学研究院 High-pressure oxidation treatment device for organic samples
CN112578728B (en) * 2020-12-15 2021-12-07 中国环境科学研究院 Switching device and method for switching gas of ICP spectrometer
CN114778717A (en) * 2022-03-28 2022-07-22 暨南大学 Online measurement method for biogenic volatile organic compounds

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043202A (en) * 1976-03-19 1977-08-23 Sun Oil Company Of Pennsylvania Sample injection system for analyzers
WO2003102573A1 (en) * 2002-05-29 2003-12-11 Dani Instruments S.P.A. Method and device for partializing a gaseous sample in chromatographic introduction
EP1457774A1 (en) * 2003-03-11 2004-09-15 Hitachi High-Technologies Corporation Separation analyser
US20050053522A1 (en) * 2003-09-10 2005-03-10 King Mackenzie E. Sampling management for a process analysis tool to minimize sample usage and decrease sampling time
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
WO2005111599A1 (en) * 2004-05-17 2005-11-24 Firmenich Sa New multidimensional gas chromatography apparatus and analyte transfer procedure using a multiple-cool strand interface

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043202A (en) * 1976-03-19 1977-08-23 Sun Oil Company Of Pennsylvania Sample injection system for analyzers
WO2003102573A1 (en) * 2002-05-29 2003-12-11 Dani Instruments S.P.A. Method and device for partializing a gaseous sample in chromatographic introduction
EP1457774A1 (en) * 2003-03-11 2004-09-15 Hitachi High-Technologies Corporation Separation analyser
US20050053522A1 (en) * 2003-09-10 2005-03-10 King Mackenzie E. Sampling management for a process analysis tool to minimize sample usage and decrease sampling time
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
WO2005111599A1 (en) * 2004-05-17 2005-11-24 Firmenich Sa New multidimensional gas chromatography apparatus and analyte transfer procedure using a multiple-cool strand interface

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GORECKI ET AL: "The evolution of comprehensive two-dimensional gas chromatography (GCxGC)", JOURNAL OF SEPARATION SCIENCE, WILEY VCH, WEINHEIM, DE, vol. 27, April 2004 (2004-04-01), pages 359 - 379, XP002337494, ISSN: 1615-9306 *
MARRIOTT P ET AL: "Cryogenic solute manipulation in gas chromatography - the longitudinal modulation approach", TRAC, TRENDS IN ANALYTICAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 2, February 1999 (1999-02-01), pages 114 - 125, XP004155356, ISSN: 0165-9936 *
MARRIOTT P ET AL: "TARGETED MULTIDIMENSIONAL GAS CHROMATOGRAPHY USING MICROSWITCHING AND CRYOGENIC MODULATION", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 75, no. 20, 15 October 2003 (2003-10-15), pages 5532 - 5538, XP001186437, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
WO2007141718A2 (en) 2007-12-13
EP2032965A2 (en) 2009-03-11

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