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WO2007038868A3 - Nouveau compose d'enediyne et ses utilisations - Google Patents

Nouveau compose d'enediyne et ses utilisations Download PDF

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Publication number
WO2007038868A3
WO2007038868A3 PCT/CA2006/001634 CA2006001634W WO2007038868A3 WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3 CA 2006001634 W CA2006001634 W CA 2006001634W WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
uncialamycin
methods
compound
kill
Prior art date
Application number
PCT/CA2006/001634
Other languages
English (en)
Other versions
WO2007038868A2 (fr
Inventor
Julian E Davies
Raymond J Anderson
Hao Wang
Koaru Warabi
Xin Hui Huang
Original Assignee
Univ British Columbia
Julian E Davies
Raymond J Anderson
Hao Wang
Koaru Warabi
Xin Hui Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia, Julian E Davies, Raymond J Anderson, Hao Wang, Koaru Warabi, Xin Hui Huang filed Critical Univ British Columbia
Publication of WO2007038868A2 publication Critical patent/WO2007038868A2/fr
Publication of WO2007038868A3 publication Critical patent/WO2007038868A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un nouveau composé d'énédiyne, l'uncialamycine, et ses analogues. Elle concerne également des méthodes d'utilisation du composé pour traiter des infections bactériennes, inhiber la croissance bactérienne, et tuer des bactéries. Le composé de l'invention peut également être utilisé pour traiter des tumeurs, empêcher la croissance de cellules tumorales, tuer des cellules tumorales, traiter des cancers, empêcher la croissance de cellules cancéreuses, et tuer des cellules cancéreuses. L'invention concerne aussi des méthodes de production d'analogues d'uncialamycine. Elle concerne en outre des compositions comprenant l'uncialamycine et des méthodes d'administration des compositions de l'invention.
PCT/CA2006/001634 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations WO2007038868A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72240705P 2005-10-03 2005-10-03
US60/722,407 2005-10-03

Publications (2)

Publication Number Publication Date
WO2007038868A2 WO2007038868A2 (fr) 2007-04-12
WO2007038868A3 true WO2007038868A3 (fr) 2007-11-08

Family

ID=37906518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2006/001634 WO2007038868A2 (fr) 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations

Country Status (1)

Country Link
WO (1) WO2007038868A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2814829B1 (fr) * 2012-02-13 2016-12-07 Bristol-Myers Squibb Company Composés d'ènediyne, leurs conjugués ainsi qu'utilisations et procédés s'y rattachant
CN105899515B (zh) * 2013-08-14 2020-01-14 威廉马歇莱思大学 uncialamycin的衍生物、合成方法及其作为抗肿瘤剂的用途
EA201691589A1 (ru) 2014-03-20 2017-02-28 Бристол-Маерс Сквибб Компани Стабилизированные основанные на фибронектине каркасные молекулы
CA2968357A1 (fr) 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Anticorps anti-cd73 et leurs utilisations
CN107250157B (zh) 2014-11-21 2021-06-29 百时美施贵宝公司 包含修饰的重链恒定区的抗体
CN107406494B (zh) 2014-11-25 2022-03-25 百时美施贵宝公司 用于成像的新型pd-l1结合多肽
WO2016112282A1 (fr) * 2015-01-08 2016-07-14 The Scripps Research Institute Candidats médicamenteux anticancéreux
US10676773B2 (en) 2015-03-10 2020-06-09 Bristol-Myers Squibb Company Antibodies conjugatable by transglutaminase and conjugates made therefrom
TN2019000101A1 (en) 2015-05-29 2020-07-15 Bristol Myers Squibb Co Antibodies against ox40 and uses thereof.
CN108025071B (zh) * 2015-09-17 2022-11-01 斯克利普斯研究院 双重可变结构域免疫缀合物及其用途
ES2809125T3 (es) 2015-09-23 2021-03-03 Bristol Myers Squibb Co Moléculas de armazón a base de fibronectina de unión a glipicano-3
JP2019505575A (ja) 2015-12-21 2019-02-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 部位特異的な結合のための変異型抗体
IL295230A (en) 2016-03-04 2022-10-01 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
WO2018048975A1 (fr) 2016-09-09 2018-03-15 Bristol-Myers Squibb Company Utilisation d'un anticorps anti-pd-1 en combinaison avec un anticorps anti-mésothéline dans le traitement du cancer
EP4098662A1 (fr) 2017-05-25 2022-12-07 Bristol-Myers Squibb Company Anticorps comprenant des régions constantes de chaîne lourde modifiées
JP2022513653A (ja) 2018-11-28 2022-02-09 ブリストル－マイヤーズ スクイブ カンパニー 修飾された重鎖定常領域を含む抗体
SG11202105565UA (en) 2018-11-30 2021-06-29 Bristol Myers Squibb Co Antibody comprising a glutamine-containing light chain c-terminal extension, conjugates thereof, and methods and uses
EP3894443A2 (fr) 2018-12-12 2021-10-20 Bristol-Myers Squibb Company Anticorps modifiés pour la conjugaison de la transglutaminase, conjugués associés, et méthodes et utilisations
US20240377413A1 (en) 2019-09-16 2024-11-14 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
CN116813627B (zh) * 2023-06-15 2025-08-12 哈药慈航制药股份有限公司 一种天赐霉素类似物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVIES ET AL.: "UNCIALAMYCIN, A NEW ENEDIYNE ANTIBIOTIC", ORGANIC LETTERS, vol. 7, no. 23, 13 October 2005 (2005-10-13), pages 5233 - 5236, XP055154051, DOI: doi:10.1021/ol052081f *

Also Published As

Publication number Publication date
WO2007038868A2 (fr) 2007-04-12

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