[go: up one dir, main page]

WO2007034278A3 - Antagonistes du recepteur du c3a - Google Patents

Antagonistes du recepteur du c3a Download PDF

Info

Publication number
WO2007034278A3
WO2007034278A3 PCT/IB2006/002561 IB2006002561W WO2007034278A3 WO 2007034278 A3 WO2007034278 A3 WO 2007034278A3 IB 2006002561 W IB2006002561 W IB 2006002561W WO 2007034278 A3 WO2007034278 A3 WO 2007034278A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
imidazole derivatives
fused imidazole
treating
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/002561
Other languages
English (en)
Other versions
WO2007034278A2 (fr
Inventor
Michelle Marie Claffey
Steven Wayne Goldstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of WO2007034278A2 publication Critical patent/WO2007034278A2/fr
Publication of WO2007034278A3 publication Critical patent/WO2007034278A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention porte sur des composés imidazo[4,5-c] pyridine à substitution aryle. Ces composés sont utiles dans des compositions pharmaceutiques comme antagonistes du C3a pour traiter différentes affections médicales associées à la cascade du complément. L'invention porte également sur des méthodes de traitement correspondantes.
PCT/IB2006/002561 2005-09-19 2006-09-18 Antagonistes du recepteur du c3a Ceased WO2007034278A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71845105P 2005-09-19 2005-09-19
US60/718,451 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007034278A2 WO2007034278A2 (fr) 2007-03-29
WO2007034278A3 true WO2007034278A3 (fr) 2007-05-18

Family

ID=37779396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002561 Ceased WO2007034278A2 (fr) 2005-09-19 2006-09-18 Antagonistes du recepteur du c3a

Country Status (1)

Country Link
WO (1) WO2007034278A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2485113C2 (ru) * 2007-11-02 2013-06-20 Хатчисон Медифарма Энтерпрайзис Ингибиторы цитокинов

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4738419B2 (ja) * 2005-11-30 2011-08-03 富士フイルムＲｉファーマ株式会社 アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
US20110021513A1 (en) * 2006-09-07 2011-01-27 Biogen Idec Ma Inc. Modulators of interleukin-1 receptor-associated kinase
EP2184273A1 (fr) 2008-11-05 2010-05-12 Bayer CropScience AG Composés substitués par l'halogène comme pesticides
PH12012501841B1 (en) * 2010-03-18 2018-01-12 Inst Nat Sante Rech Med Anti-infective compounds
WO2011137587A1 (fr) * 2010-05-06 2011-11-10 Hutchison Medipharma Limited Inhibiteurs de cytokines
AU2012272706B2 (en) 2011-06-22 2017-07-06 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
WO2014172190A1 (fr) 2013-04-15 2014-10-23 E. I. Du Pont De Nemours And Company Amides fongicides
EP3302710A4 (fr) 2015-06-03 2019-02-20 The University of Queensland Agents mobilisateurs et leurs utilisations
CN111377917B (zh) * 2018-12-29 2022-12-06 武汉朗来科技发展有限公司 杂环类化合物、中间体、其制备方法及应用
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺
WO2025166319A1 (fr) 2024-02-02 2025-08-07 The Broad Institute, Inc. Inhibiteurs de la cascade du complément

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001030778A1 (fr) * 1999-10-27 2001-05-03 Novartis Ag Composes thiazole et imidazo [4,5-b] pyridine et leur utilisation pharmaceutique
EP1104762A1 (fr) * 1998-08-03 2001-06-06 Laboratorios S.A.L.V.A.T., S.A. Imidazo 1,2a]azines substituees servant d'inhibiteurs selectifs de la cox-2
WO2001057038A1 (fr) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Composes heterocycliques et leur utilisation comme inhibiteurs de parp
WO2003051890A1 (fr) * 2001-12-14 2003-06-26 Aegera Therapeutics Inc. Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides
WO2004111061A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4,-thiadiazole-2-sulfonamides acyles et non acyles, et utilisations associees
WO2004111060A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4-thiadiazole sulfoxydes et sulfones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1104762A1 (fr) * 1998-08-03 2001-06-06 Laboratorios S.A.L.V.A.T., S.A. Imidazo 1,2a]azines substituees servant d'inhibiteurs selectifs de la cox-2
WO2001030778A1 (fr) * 1999-10-27 2001-05-03 Novartis Ag Composes thiazole et imidazo [4,5-b] pyridine et leur utilisation pharmaceutique
WO2001057038A1 (fr) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Composes heterocycliques et leur utilisation comme inhibiteurs de parp
WO2003051890A1 (fr) * 2001-12-14 2003-06-26 Aegera Therapeutics Inc. Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides
WO2004111061A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4,-thiadiazole-2-sulfonamides acyles et non acyles, et utilisations associees
WO2004111060A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4-thiadiazole sulfoxydes et sulfones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2485113C2 (ru) * 2007-11-02 2013-06-20 Хатчисон Медифарма Энтерпрайзис Ингибиторы цитокинов

Also Published As

Publication number Publication date
WO2007034278A2 (fr) 2007-03-29

Similar Documents

Publication Publication Date Title
WO2007034282A3 (fr) Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a
IL185611A0 (en) Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same
EA201000615A1 (ru) Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы)
IL204693A0 (en) Imidazo[1, 2 - a] pyrimidine derivatives for the treatment of diseases such as diabetes
MX2009012567A (es) 3-(imidazolil)-pirazolo[3,4-b]piridinas.
WO2007028135A3 (fr) Composes a base d'imidazopyridine
WO2007027734A3 (fr) Heterocycles d'azote pontes et bicycliques
ZA201000212B (en) Fused heteroaryl pyridyl and phenyl benzenesulfonamides as ccr2 modulators for the treatment of inflammation
MX2009004715A (es) Compuestos heterociclicos como agentes antiinflamatorios.
WO2007106469A3 (fr) Derives bicycliques de l'acide carboxylique utiles dans le traitement de troubles metaboliques
WO2006126081A3 (fr) Pyridine [2,3-b] pyrazinones
GEP20135780B (en) Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents
WO2009016564A3 (fr) Dérivés de 2-aza-bicyclo[3.3.0]octane
PL1904494T3 (pl) Związki imidazo[1,2-A]pirydynowe jako inhibitory VEGF-R2
WO2006067614A3 (fr) Derives heteroaromatiques utiles en tant qu'agents anticancereux
WO2006104826A3 (fr) Composes antagonistes du recepteur du glucagon, compositions renfermant de tels composes et methodes d'utilisation
WO2006126082A3 (fr) Pyridine [3,4-b] pyrazinones
WO2008048867A3 (fr) Composés hétoroaromatiques bicycliques
WO2007044804A3 (fr) Derives de piperidine et leurs procedes d'utilisation
WO2009156951A3 (fr) Composés de 5,6,7,8-tétrahydro-imidazo[1,5-a]pyrazine
EP1814885A4 (fr) Nouveaux composes bicycliques heterocycliques, leur procede de preparation et compositions les contenant
WO2006059149A8 (fr) Derives de l'arylsulfonylnaphtalene utilises en tant qu'antagonistes de 5ht2a
WO2007034278A3 (fr) Antagonistes du recepteur du c3a
NZ552137A (en) New 4-benzylidene-piperidin derivatives
WO2007104485A3 (fr) Composés imidazo[2,1-b]thiazole substitués et utilisation dans la fabrication de médicaments

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06808851

Country of ref document: EP

Kind code of ref document: A2