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WO2007025264A2 - Composition de bronzage topique contenant une medication - Google Patents

Composition de bronzage topique contenant une medication Download PDF

Info

Publication number
WO2007025264A2
WO2007025264A2 PCT/US2006/033599 US2006033599W WO2007025264A2 WO 2007025264 A2 WO2007025264 A2 WO 2007025264A2 US 2006033599 W US2006033599 W US 2006033599W WO 2007025264 A2 WO2007025264 A2 WO 2007025264A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
mixture
skin
turmeric
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/033599
Other languages
English (en)
Other versions
WO2007025264A3 (fr
Inventor
Alexander A. Bommarito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPRAY TANNING Inc
Original Assignee
SPRAY TANNING Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/509,350 external-priority patent/US20070048233A1/en
Priority claimed from US11/509,212 external-priority patent/US20070048393A1/en
Application filed by SPRAY TANNING Inc filed Critical SPRAY TANNING Inc
Publication of WO2007025264A2 publication Critical patent/WO2007025264A2/fr
Publication of WO2007025264A3 publication Critical patent/WO2007025264A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • This invention relates to a topical, artificial skin tanning composition
  • a topical, artificial skin tanning composition comprising a mixture of a tanning solution which darkens a person's skin and turmeric or other medication which is absorbable by the person's skin.
  • topical, artificial skin tanning preparations and the use of topical medications are well known. It also is known that some topical medications, such as turmeric and extracts thereof are objectionable to many persons because they discolor the skin in a manner they consider to be unattractive. For example, turmeric products leave a distinctive, fairly bright yellow color on skin to which they have been applied. In addition, turmeric is an excellent dye and, as a consequence, it is not uncommon for clothing to become stained when worn by a person to whose skin turmeric has been applied. [0004] Making medications available for topical application is desirable for many reasons, one of which is that many persons just do not like to take medication orally, even though the oral taking of such medications may be desirable.
  • transdermal medication delivery can be medically beneficial upon delivery to a person's skin, as well as a solution to a person's reluctance to the taking of medication orally in accordance with a prescribed regimen.
  • the medical benefits of turmeric have been known for hundreds of years. Among these benefits are those resulting from treatments for burns, including sun burns, psoriasis, and osteoporosis.
  • Natural medicines including turmeric and vitamin D, may be incorporated in topical products for treating anti-inflammatory, antiseptic, antitumor, anti-allergic, and antioxidant causes, as well as cosmetic benefits such as nourishing and softening of the skin and reducing examples of aging, such as superficial wrinkling and scaling.
  • cosmetic benefits such as nourishing and softening of the skin and reducing examples of aging, such as superficial wrinkling and scaling.
  • the tendency of turmeric to discolor the skin yellow and to stain clothing inhibits the use of turmeric.
  • Tanning can be achieved by exposure to the sun, by exposure to artificial tanning rays, and by the application to the skin of a skin-tanning solution or other preparation. Tanning by exposure to the sun or by exposure to artificial tanning rays is objected to by some persons beca ⁇ se of inconvenience, thereby leaving the application of a tanning substance to the skin as the remaining alternative.
  • artificial tanning substances currently available do not provide the user with any significant benefits, other than those associated with cosmetics.
  • a tanning substance according to the invention provides not only the cosmetic benefits, but also therapeutic benefits because of the combination of the tanning substance and medications, and in addition, such substance provides some protection as a sunscreen against erythema or sunburn.
  • DHA dihydroxyacetone
  • This substance can be combined with colorants or bronzers and other ingredients, such as moisturizers, antimicrobials, thickeners, solvents, emulsifiers, fragrances, surfactants, stabilizers, and pH adjusters. All of these ingredients and how they are combined are well known in the art.
  • a significant characteristic of the invention is the provision of a topical foam, liquid, lotion, cream, and the like composition comprising a mixture of the skin tanning substance and a medication which is active on or absorbable via the human skin.
  • An appropriate composition is one that includes the aforementioned DHA and turmeric or an extract therefrom, such as curcumin.
  • Both the DHA and the turmeric react with the skin and, after the passage of a few minutes from the application of the composition to a person's skin, the chemical reaction will cause the person's skin to darken and simulate tanning.
  • the tanning solution will not react with the turmeric but will produce a deep tan coloring and mask the yellowing.
  • An appropriate, absorbable medication which may be included in the mixture is vitamin D. Good tanning levels with local absorption of vitamin D can be achieved without adverse interactions.
  • the composition also includes a coloring agent, such as NF caramel, which instantly colors a person's skin, it is easier to obtain a uniform application of the composition to the skin because the coloring of the skin will indicate to the applier where the solution has been applied, thereby minimizing the creation of streaks and different shades of coloring.
  • a coloring agent such as NF caramel
  • NF caramel is preferred over other caramels because it provides initial masking of the turmeric yellowing and has no objectionable interaction with the medications.
  • a topical, artificial skin tanning composition according to the invention comprises a mixture of a tanning substance which darkens a person's skin and a medication which is active and may be locally or systemically absorbable by such person's skin.
  • the tanning substance preferably comprises dihydroxyacetone (DHA) which may contain an appropriate amount of water and other additives such as a coloring agent capable of masking medications, biologies, and natural medicines.
  • the medication preferably comprises turmeric or extracts therefrom, such as curcumin or curcuminoids.
  • the mixture can be of such viscosity as to be sprayable in a fine mist from a spray bottle or the like.
  • the mixture also can be in the form of a solution, foam, cream, or lotion for topical application and should contain no insoluble particles such as would interfere with the activity on or absorbance by the skin.
  • the mixture also should contain appropriate solvents for the other ingredients in the composition.
  • Aqueous solvents are adequate for topical agents that easily penetrate the skin.
  • Hydroalcohol solvents will provide acceptable absorption for other agents.
  • the invention makes possible the incorporation of turmeric and its active ingredients into topical skin care foams, creams, lotions, ointments, and sprayable solutions without turning the skin yellow or staining clothing worn by the person to whose skin the substance is applied.
  • Turmeric is commercially available as a dry powder having the standard characteristics known in pharmacognosy.
  • turmeric can vary in its concentration of active ingredients due to growing conditions and harvesting techniques, a known source and standard of turmeric can and should be used.
  • a suitable powder source is McCormick & Co., among others, and a suitable source of turmeric extract is Camden Gray Company, among others.
  • turmeric powder is weighed and a known weight of such powder is added to a solvent system for extraction of the active ingredients (curcumin, curcuminoids) of the turmeric.
  • solvent systems are well known and a good review thereof is available in the Journal of Agriculture and Food Chemistry (2003).
  • a typical procedure combines lOOcc of ethanol with lOOcc of isopropyl alcohol and lOOcc of acetone with 30 grams of turmeric powder.
  • Other procedures and concentrations may be used.
  • the active ingredients of turmeric are in the soluble liquid portion of the mixture. If allowed to dry, two distinct layers will be formed. The top layer will include the color red mixed with the characteristic yellow color.
  • the liquid phase containing the many active ingredients of turmeric is used. They are added to a composition containing blueberries, coffee berries or beans, green tea extract, or pomegranate extract formulated to receive the turmeric and eliminate or mask its characteristic yellow color.
  • the blueberries or skins thereof are broken and mixed well with lemon or other citrus juice in about equal parts.
  • the mixture is heated to a level below the boiling temperature of the mixture until the ingredients are thoroughly mixed.
  • the heating step assists in the proper color development or biochemical extraction of the active phytochemicals.
  • the liquid phase of the mixture is separated from the solid phase by allowing the mixture to stand, or by filtration.
  • the liquid phase then is combined with the turmeric or extract at the desired concentration.
  • the filtrate may be at ambient or a somewhat higher temperature as a result of heating.
  • Acceptable concentrations range from about 0.5cc to 4.0cc of turmeric extract to lOcc blueberry lemon juice mixture.
  • the resulting solution provides an adequate therapeutic concentration of the turmeric active ingredients for topical use without the yellow staining characteristics.
  • the solution containing the turmeric extract and blueberry-lemon juice mixture may be incorporated into an ointment base which accepts a liquid solution.
  • an ointment base such as a hydrophilic absorption base available under the trademark AQUAPHOR from Biersdof, Inc.
  • AQUAPHOR available under the trademark AQUAPHOR from Biersdof, Inc.
  • AQUAPHOR available under the trademark AQUAPHOR from Biersdof, Inc.
  • a mixture containing the other ingredients referred to above may be prepared in substantially the same way.
  • Such other ingredients also may be included with the blueberry-based substance in desired proportions if an increase in the concentration of turmeric is desired.
  • the combining of the ingredients is easily accomplished in known ways by persons skilled in the art.
  • the turmeric active ingredients referred to above are combined only with common body solutions, lotions, ointments, or the like, the resultant substance will have a yellow appearance and, if applied to a person's skin, will stain the skin yellow.
  • combining the same concentration of the turmeric active ingredients with the blueberry-lemon juice mixture and then incorporating the combination in a solution, lotion, ointment, or the like results in a product having a blue, tan, or brown appearance according to the concentration of the turmeric.
  • the resulting product does not possess the staining properties common to blueberries or turmeric or the active ingredients thereof.
  • blueberries and lemon juice are preferred, it is possible to use huckleberries, coffee beans, green tea extract, pomegranate, bilberries, bearberries, moonseed berries, mountain currant (ribes novadense), and blue/ purple grapes of many varieties, in lieu of the blueberries.
  • lemon juice other citrus juices may be used.
  • Other coloring, natural or synthetic also may be used without departing from the scope of the invention.
  • the composition mixture may contain the tanning substance, DHA, with colorants to reveal application areas concurrently with application and assist in masking the color of medications, biologic, and natural medicines.
  • Color additives can include NF caramel, at approximately .01% to 5%; yellow 5 food coloring at approximately 0.01 to 1%; blue 1 food coloring at approximately 0.01 to 3%; or red 4 food coloring at approximately 0.01% to 3%, or other natural colors as needed. AU percentages are by volume.
  • the composition also can contain vitamin D at an approximate concentration of 100 IU to 2000 IU/ml.
  • the composition may contain turmeric or extracts thereof at approximately 0.1% to 15%, by volume, utilizing solvent extraction by means of water, ethanol, isopropyl alcohol, acetone, and their mixtures in all proportions or hydrodistillation or supercritical extraction using carbon dioxide and cosolvents.
  • the tanning composition includes both vitamin D and turmeric products, the vitamin D should be at a concentration of about 100 IU to 2000 IU/ml and the turmeric products at the percentages specified.
  • the tanning composition can include other medications, such as biologic or natural medications, for topical use at therapeutic concentrations. For example, ibuprofen in a concentration of 10% - 20% can be dissolved in a hydroalcohol base solution having a pH of about 5.0.
  • Natural medications such as green tea, pomegranate, coffee beans, and amino acids have been included in the composition at volume percentages from 0.01 to 6.0 with good results. Glutamine as an amino acid and pomegranate may be included in such product. No reactions or breakdowns of DHA have occurred in stability testings at the preferred concentrations.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition de bronzage cutané artificiel topique comprenant un mélange de substance de bronzage qui brunit la peau d'une personne et d'une médication qui est active sur la peau et/ou absorbable par la peau de cette personne. La substance de bronzage peut-être dihydroxyacétone, la médication peut-être turméric et le mélange est un mélange qui peut être pulvérisé ou appliqué directement sur la peau d'une personne. Toute couleur non souhaitable de la médication est masquée par la substance de bronzage.
PCT/US2006/033599 2005-08-26 2006-08-25 Composition de bronzage topique contenant une medication Ceased WO2007025264A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US71147405P 2005-08-26 2005-08-26
US60/711,474 2005-08-26
US71356005P 2005-09-01 2005-09-01
US60/713,560 2005-09-01
US11/509,350 US20070048233A1 (en) 2005-08-26 2006-08-24 Artificial tanning composition containing medication
US11/509,212 2006-08-24
US11/509,350 2006-08-24
US11/509,212 US20070048393A1 (en) 2005-09-01 2006-08-24 Topical turmeric skin care products

Publications (2)

Publication Number Publication Date
WO2007025264A2 true WO2007025264A2 (fr) 2007-03-01
WO2007025264A3 WO2007025264A3 (fr) 2007-10-25

Family

ID=37772514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033599 Ceased WO2007025264A2 (fr) 2005-08-26 2006-08-25 Composition de bronzage topique contenant une medication

Country Status (1)

Country Link
WO (1) WO2007025264A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120134938A1 (en) * 2010-11-30 2012-05-31 Perricone Nicholas V Melanin Promoting Topical Composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE588291A (fr) * 1959-03-09
AU7880700A (en) * 1999-08-16 2001-03-13 Dung Phan Compositions and methods of treatment for skin conditions using extracts of turmeric
US6521668B2 (en) * 1999-12-14 2003-02-18 Avon Products, Inc. Cosmetic composition and methods of use
US6300299B1 (en) * 2001-02-06 2001-10-09 E. I. Du Pont De Nemours And Company Process for cleaning turmeric stains
US6875426B2 (en) * 2002-03-28 2005-04-05 L'oreal Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120134938A1 (en) * 2010-11-30 2012-05-31 Perricone Nicholas V Melanin Promoting Topical Composition
WO2012074672A1 (fr) * 2010-11-30 2012-06-07 N.V. Perricone Llc Composition topique pour favoriser la mélanine
US8414869B2 (en) 2010-11-30 2013-04-09 N.V. Perricone Llc Melanin promoting topical composition
CN103338741A (zh) * 2010-11-30 2013-10-02 N.V.佩里科恩有限责任公司 促进黑色素的局部组合物
JP2013544283A (ja) * 2010-11-30 2013-12-12 エヌ・ブイ・ペリコーン・リミテッド・ライアビリティ・カンパニー メラニン促進局所用組成物
EP2645983A4 (fr) * 2010-11-30 2014-04-23 Perricone Nv Llc Composition topique pour favoriser la mélanine
AU2011337131B2 (en) * 2010-11-30 2015-11-19 N.V. Perricone Llc Melanin promoting topical composition

Also Published As

Publication number Publication date
WO2007025264A3 (fr) 2007-10-25

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