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WO2007024744A3 - Heterocyclic carboxamide compounds as steroid nuclear receptor ligands - Google Patents

Heterocyclic carboxamide compounds as steroid nuclear receptor ligands Download PDF

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Publication number
WO2007024744A3
WO2007024744A3 PCT/US2006/032459 US2006032459W WO2007024744A3 WO 2007024744 A3 WO2007024744 A3 WO 2007024744A3 US 2006032459 W US2006032459 W US 2006032459W WO 2007024744 A3 WO2007024744 A3 WO 2007024744A3
Authority
WO
WIPO (PCT)
Prior art keywords
nuclear receptor
receptor ligands
carboxamide compounds
steroid nuclear
heterocyclic carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/032459
Other languages
French (fr)
Other versions
WO2007024744A2 (en
Inventor
Brenton T Flatt
Xiao Hui Gu
Richard Martin
Raju Mohan
Brett Murphy
Michael Charles Nyman
William C Stevens
Tie Lin Wang
Lynne Canne Bannen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exelixis Inc
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of WO2007024744A2 publication Critical patent/WO2007024744A2/en
Publication of WO2007024744A3 publication Critical patent/WO2007024744A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Heterocyclic carboxamide compounds are described herein as being useful in modulating the activity of steroid nuclear receptors. Pharmaceutical compositions containing the compounds, methods of using the compounds and processes for making the compounds are also described.
PCT/US2006/032459 2005-08-21 2006-08-18 Heterocyclic carboxamide compounds as steroid nuclear receptor ligands Ceased WO2007024744A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71027305P 2005-08-21 2005-08-21
US60/710,273 2005-08-21

Publications (2)

Publication Number Publication Date
WO2007024744A2 WO2007024744A2 (en) 2007-03-01
WO2007024744A3 true WO2007024744A3 (en) 2007-06-07

Family

ID=37684876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032459 Ceased WO2007024744A2 (en) 2005-08-21 2006-08-18 Heterocyclic carboxamide compounds as steroid nuclear receptor ligands

Country Status (1)

Country Link
WO (1) WO2007024744A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0815668A2 (en) * 2007-08-22 2017-05-23 Allergan Inc pyrrol compounds having sphingosine-1-phosphate receptor antagonist and agonist biological activity.
JO3215B1 (en) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag Carboxamide or Sulfonamide Substituted Nitrogen-Containing 5-Membered Heterocycles as Modulators for the Orphan Nuclear Receptor RORy
WO2014108336A1 (en) 2013-01-10 2014-07-17 Grünenthal GmbH Pyrazolyl-based carboxamides ii as crac channel inhibitors
WO2014108337A1 (en) 2013-01-10 2014-07-17 Grünenthal GmbH Pyrazolyl-based carboxamides i as crac channel inhibitors
WO2015197187A1 (en) 2014-06-24 2015-12-30 Grünenthal GmbH Pyrazolyl-based carboxamides v
ES2950757T3 (en) 2017-10-06 2023-10-13 Forma Therapeutics Inc Inhibition of ubiquitin 30-specific peptidase
BR112020021921A2 (en) 2018-05-17 2021-01-26 Forma Therapeutics, Inc. fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors
LT3860989T (en) 2018-10-05 2023-06-12 Forma Therapeutics, Inc. FUSION PYROLINES THAT ACT AS INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 30 (UPS30)
JP2023519892A (en) 2020-03-27 2023-05-15 ランドス バイオファーマ インコーポレイテッド PLXDC2 ligand
WO2024059524A1 (en) * 2022-09-12 2024-03-21 Hotspot Therapeutics, Inc. Pyrazolylcarboxamide compounds and their use in therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007887A2 (en) * 2001-07-20 2003-01-30 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
WO2003027076A2 (en) * 2001-09-21 2003-04-03 Solvay Pharmaceuticals B.V. 1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1- antagonistic activity
WO2003063781A2 (en) * 2002-01-29 2003-08-07 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
WO2004085419A1 (en) * 2003-03-24 2004-10-07 Basf Aktiengesellschaft Trifluoromethyl-thiophene carboxylic acid anilides and use thereof as fungicides
WO2006076202A1 (en) * 2005-01-10 2006-07-20 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptors ligands

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007887A2 (en) * 2001-07-20 2003-01-30 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
WO2003027076A2 (en) * 2001-09-21 2003-04-03 Solvay Pharmaceuticals B.V. 1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1- antagonistic activity
WO2003063781A2 (en) * 2002-01-29 2003-08-07 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
WO2004085419A1 (en) * 2003-03-24 2004-10-07 Basf Aktiengesellschaft Trifluoromethyl-thiophene carboxylic acid anilides and use thereof as fungicides
WO2006076202A1 (en) * 2005-01-10 2006-07-20 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptors ligands

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANTOLINI M ET AL: "Analogues of 4,5-bis(3,5-dichlorophenyl)-2- trifluoromethyl-1H-imidazole as potential antibacterial agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 7, 5 April 1999 (1999-04-05), pages 1023 - 1028, XP004162577 *
CAPUANO L ET AL: "Chemie der 2,3-Dihydro-2,3-diiminofurane", LIEBIGS ANNALEN DER CHEMIE, vol. 12, 1982, pages 2178 - 2188, XP002188095 *
DYCK B ET AL: "Potent imidazole and triazole CB1 receptor antagonists related to SR141716", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 5, 8 March 2004 (2004-03-08), pages 1151 - 1154, XP001197288 *
GOMPPER R ET AL: "Umsetzung von Imidazolen mit Isocyanaten", CHEMISCHE BERICHTE, vol. 92, no. 3, 12 March 1959 (1959-03-12), pages 550 - 563, XP002378856 *
KUDO N ET AL: "Synthesis and herbicidal activity of 1,5-diarylpyrazole derivatives", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 47, no. 6, 1999, pages 857 - 868, XP001026111 *
LAN R ET AL: "Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 4, 1999, pages 769 - 776, XP002145465 *
PAPADOPOULOS E P: "Reactions of imidazoles with isocyanates at elevated temperature", JOURNAL OF ORGANIC CHEMISTRY, vol. 42, no. 24, 25 November 1977 (1977-11-25), pages 3925 - 3929, XP002378857 *
SHIM J-Y ET AL: "Molecular interaction of the antagonist N-(piperidin-1-yl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 7, March 2002 (2002-03-01), pages 1447 - 1459, XP002968557 *
TRANBERG C E ET AL: "2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 45, no. 2, 19 December 2002 (2002-12-19), pages 382 - 389, XP002378855, ISSN: 0022-2623 *
UEDA T ET AL: "A novel ring transformation of 5-acylaminouracils and 5-acylamino-pyrimidin-4(3H)-ones into imidazoles", TETRAHEDRON LETTERS, vol. 29, no. 36, 1988, pages 4607 - 4610, XP001038533 *

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Publication number Publication date
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