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WO2007022331A3 - Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor - Google Patents

Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor Download PDF

Info

Publication number
WO2007022331A3
WO2007022331A3 PCT/US2006/032079 US2006032079W WO2007022331A3 WO 2007022331 A3 WO2007022331 A3 WO 2007022331A3 US 2006032079 W US2006032079 W US 2006032079W WO 2007022331 A3 WO2007022331 A3 WO 2007022331A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
nitric oxide
oxide synthase
subject suffering
disc disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/032079
Other languages
French (fr)
Other versions
WO2007022331A2 (en
Inventor
Peter A Zahos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Discogen LLC
Original Assignee
Discogen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Discogen LLC filed Critical Discogen LLC
Priority to EP06813496A priority Critical patent/EP1931328A4/en
Publication of WO2007022331A2 publication Critical patent/WO2007022331A2/en
Anticipated expiration legal-status Critical
Publication of WO2007022331A3 publication Critical patent/WO2007022331A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method for treating a vertebrate subject suffering from a degenerative disc disease by administering an inhibitor of nitric oxide synthase (NOS) to the subject in an amount effective to treat the subject.
PCT/US2006/032079 2005-08-16 2006-08-15 Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor Ceased WO2007022331A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06813496A EP1931328A4 (en) 2005-08-16 2006-08-15 Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US70843005P 2005-08-16 2005-08-16
US60/708,430 2005-08-16
US72755205P 2005-10-18 2005-10-18
US60/727,552 2005-10-18
US77366606P 2006-02-16 2006-02-16
US60/773,666 2006-02-16

Publications (2)

Publication Number Publication Date
WO2007022331A2 WO2007022331A2 (en) 2007-02-22
WO2007022331A3 true WO2007022331A3 (en) 2009-04-16

Family

ID=37758382

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032079 Ceased WO2007022331A2 (en) 2005-08-16 2006-08-15 Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor

Country Status (3)

Country Link
US (1) US20070043118A1 (en)
EP (1) EP1931328A4 (en)
WO (1) WO2007022331A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346519B1 (en) * 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929063A (en) * 1995-03-24 1999-07-27 Children's Hospital Medical Center Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
US7014633B2 (en) * 2000-02-16 2006-03-21 Trans1, Inc. Methods of performing procedures in the spine
BRPI0410331A (en) * 2003-05-13 2006-05-30 Depuy Spine Inc Method to Treat Degenerative Disc Disease
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
JP2008504895A (en) * 2004-06-29 2008-02-21 スパイン・ウェイブ・インコーポレーテッド Method for treating disc defects and injuries

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346519B1 (en) * 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GORGIAS, N. K. ET AL.: "An appreciation of the role of nitric oxide in pain pathophysiology.", THE GREEK E-JOUMAL OF PERIOPERATIVE MEDICINE, November 2003 (2003-11-01), Retrieved from the Internet <URL:http://www.anesthesia.gr/ejournal/docs/2003/1Gorgias.pdf> [retrieved on 20070323] *
See also references of EP1931328A4 *

Also Published As

Publication number Publication date
US20070043118A1 (en) 2007-02-22
EP1931328A4 (en) 2011-07-13
EP1931328A2 (en) 2008-06-18
WO2007022331A2 (en) 2007-02-22

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