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WO2007017895A3 - Stabilized oral pharmaceutical compositions of cephalosporins - Google Patents

Stabilized oral pharmaceutical compositions of cephalosporins Download PDF

Info

Publication number
WO2007017895A3
WO2007017895A3 PCT/IN2006/000160 IN2006000160W WO2007017895A3 WO 2007017895 A3 WO2007017895 A3 WO 2007017895A3 IN 2006000160 W IN2006000160 W IN 2006000160W WO 2007017895 A3 WO2007017895 A3 WO 2007017895A3
Authority
WO
WIPO (PCT)
Prior art keywords
cephalosporin
oral pharmaceutical
stability
pharmaceutical compositions
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2006/000160
Other languages
French (fr)
Other versions
WO2007017895A2 (en
Inventor
Himadri Sen
Makarand Avachat
Sanjay Wagh
Bharat Metkar
Abhijit Dhamne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lupin Ltd
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Priority to EP06809918A priority Critical patent/EP1883393A2/en
Priority to JP2008509579A priority patent/JP2008540403A/en
Publication of WO2007017895A2 publication Critical patent/WO2007017895A2/en
Publication of WO2007017895A3 publication Critical patent/WO2007017895A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oral pharmaceutical compositions of cephalosporins, particularly Cefpodoxime, aproces for preparing the same and a method for enhancing the stability of these oral pharmaceutical compositions. The oral pharmaceutical composition of a cephalosporin, is stable and has adequate bio-availability, and comprises the cephalosporin and maize starch. The process for preparing an oral pharmaceutical composition of a cephalosporin comprises the steps of reducing the size of the cephalosporin and mixing with maize starch and one or more excipients. The method of enhancing the stability profile of a cephalosporin in a pharmaceutical composition comprises contacting the cephalosporin with a stability - enhancing amount of maize starch with a moisture content of not more than 2%. The oral suspension exhibits an improved stability profile as compared to an oral suspension pharmaceutical composition comprising the said cephalosporin which does not contain maize starch in a stability - enhancing amount.
PCT/IN2006/000160 2005-05-05 2006-05-05 Stabilized oral pharmaceutical compositions of cephalosporins Ceased WO2007017895A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06809918A EP1883393A2 (en) 2005-05-05 2006-05-05 Stabilized oral pharmaceutical compositions of cephalosporins
JP2008509579A JP2008540403A (en) 2005-05-05 2006-05-05 Stabilized oral pharmaceutical composition of cephalosporin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN556MU2005 2005-05-05
IN556/MUM/2005 2005-05-05

Publications (2)

Publication Number Publication Date
WO2007017895A2 WO2007017895A2 (en) 2007-02-15
WO2007017895A3 true WO2007017895A3 (en) 2007-04-19

Family

ID=37672426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000160 Ceased WO2007017895A2 (en) 2005-05-05 2006-05-05 Stabilized oral pharmaceutical compositions of cephalosporins

Country Status (3)

Country Link
EP (1) EP1883393A2 (en)
JP (1) JP2008540403A (en)
WO (1) WO2007017895A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201007107A1 (en) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Formulations of cefpodoxime proxetil containing taste regulating agent.
TR201007106A1 (en) * 2010-08-25 2012-03-21 Bi̇lgi̇ç Mahmut Cefpodoxime proxetil formulations.
TR201009167A2 (en) * 2010-11-05 2012-05-21 Bi̇lgi̇ç Mahmut Pharmaceutical granules containing cephalosporin.
TR201009168A2 (en) * 2010-11-05 2012-05-21 Bi̇lgi̇ç Mahmut Water dispersible cefpodoxime proxetil formulations.
JP2013147488A (en) * 2011-12-21 2013-08-01 Taisho Pharmaceutical Co Ltd Solid preparation
CA2914468A1 (en) * 2013-07-18 2015-01-22 Sandoz Ag Powder mixtures for antibiotic dry syrup formulations
CN103479589B (en) * 2013-09-22 2016-04-13 海南葫芦娃制药有限公司 cefpodoxime proxetil dispersible tablet and preparation method thereof
WO2017046756A1 (en) * 2015-09-18 2017-03-23 Lupin Limited Proxetil and axetil esters of cefixime

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1132583A (en) * 1964-12-16 1968-11-06 Glaxo Lab Ltd Pharmaceutical compositions containing cephalosporins
US3931404A (en) * 1972-12-06 1976-01-06 Hoechst Aktiengesellschaft High dosage orally administrable cephalosporin antibiotic preparations
US3945994A (en) * 1973-02-08 1976-03-23 Gist-Brocades N.V. Novel acid compounds
WO2002067943A1 (en) * 2001-02-27 2002-09-06 Ranbaxy Laboratories Limited Oral pharmaceutical composition of cefpodoxime proxetil
WO2004022727A1 (en) * 2002-09-06 2004-03-18 Vri Biomedical Ltd Probiotic bacterium: lactobacillus fermentum

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1132583A (en) * 1964-12-16 1968-11-06 Glaxo Lab Ltd Pharmaceutical compositions containing cephalosporins
US3931404A (en) * 1972-12-06 1976-01-06 Hoechst Aktiengesellschaft High dosage orally administrable cephalosporin antibiotic preparations
US3945994A (en) * 1973-02-08 1976-03-23 Gist-Brocades N.V. Novel acid compounds
WO2002067943A1 (en) * 2001-02-27 2002-09-06 Ranbaxy Laboratories Limited Oral pharmaceutical composition of cefpodoxime proxetil
WO2004022727A1 (en) * 2002-09-06 2004-03-18 Vri Biomedical Ltd Probiotic bacterium: lactobacillus fermentum

Also Published As

Publication number Publication date
WO2007017895A2 (en) 2007-02-15
JP2008540403A (en) 2008-11-20
EP1883393A2 (en) 2008-02-06

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