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WO2007017652A3 - Arylakylamines for the treatment of cancer - Google Patents

Arylakylamines for the treatment of cancer Download PDF

Info

Publication number
WO2007017652A3
WO2007017652A3 PCT/GB2006/002930 GB2006002930W WO2007017652A3 WO 2007017652 A3 WO2007017652 A3 WO 2007017652A3 GB 2006002930 W GB2006002930 W GB 2006002930W WO 2007017652 A3 WO2007017652 A3 WO 2007017652A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
treatment
arylakylamines
pyridineethanamine
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/002930
Other languages
French (fr)
Other versions
WO2007017652A2 (en
Inventor
Reginald Bowie Ewesuedo
Gerardus Johannes Cl Kolvenbag
Dennis Joseph Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
AstraZeneca AB
Original Assignee
AstraZeneca UK Ltd
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd, AstraZeneca AB filed Critical AstraZeneca UK Ltd
Publication of WO2007017652A2 publication Critical patent/WO2007017652A2/en
Publication of WO2007017652A3 publication Critical patent/WO2007017652A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the use of arylalkyl-amines and -amides, particularly (S)-α-phenyl-2-pyridineethanamine, or pharmaceutically acceptable salts thereof, in the treatment of cancer in a warm-blooded animal such as man. Further aspects of the invention include a method of treating cancer, and to the use of arylalkyl-amines and -amides, particularly (S)-α-phenyl-2-pyridineethanamine, or pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in a method of treating cancer.
PCT/GB2006/002930 2005-08-10 2006-08-08 Arylakylamines for the treatment of cancer Ceased WO2007017652A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70691605P 2005-08-10 2005-08-10
US60/706,916 2005-08-10

Publications (2)

Publication Number Publication Date
WO2007017652A2 WO2007017652A2 (en) 2007-02-15
WO2007017652A3 true WO2007017652A3 (en) 2007-05-31

Family

ID=37727678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002930 Ceased WO2007017652A2 (en) 2005-08-10 2006-08-08 Arylakylamines for the treatment of cancer

Country Status (1)

Country Link
WO (1) WO2007017652A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4208438A4 (en) * 2020-08-28 2025-01-22 The Regents of the University of California COMPOSITIONS AND METHODS FOR TREATING AMYLOID-RELATED PATHOLOGICAL CONDITIONS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011995A1 (en) * 1988-08-12 1991-08-22 Fisons Corporation Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
WO1993020052A1 (en) * 1992-04-03 1993-10-14 Fisons Corporation Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders
WO2000024395A1 (en) * 1998-10-28 2000-05-04 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011995A1 (en) * 1988-08-12 1991-08-22 Fisons Corporation Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
WO1993020052A1 (en) * 1992-04-03 1993-10-14 Fisons Corporation Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders
WO2000024395A1 (en) * 1998-10-28 2000-05-04 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GREENE J G ET AL: "ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology.", EXPERIMENTAL NEUROLOGY JAN 1996, vol. 137, no. 1, January 1996 (1996-01-01), pages 66 - 72, XP002421391, ISSN: 0014-4886 *
HARTWELL, JONATHAN L. ET AL: "Chemical treatment of tumors. XI. Some .alpha.,.beta.- diphenylethylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 67, 1606-8 CODEN: JACSAT; ISSN: 0002-7863, 1945, XP002421390 *
LEITER J ET AL: "Negative results with diphenylethylamines in producing damage in sarcoma 37.", CANCER RESEARCH 1955, vol. Suppl. 2, 1955, pages 109 - 123, XP002421389, ISSN: 0008-5472 *
OWARI S: "Effect of alpha,beta-diphenylethylamines upon Yoshida sarcoma.", PHARMACEUTICAL BULLETIN JUN 1953, vol. 1, no. 2, June 1953 (1953-06-01), pages 174 - 176, XP009079500 *

Also Published As

Publication number Publication date
WO2007017652A2 (en) 2007-02-15

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