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WO2007016950A1 - Composition réduisant les risques de maladie neurodégénérative induite par l’alcool - Google Patents

Composition réduisant les risques de maladie neurodégénérative induite par l’alcool Download PDF

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Publication number
WO2007016950A1
WO2007016950A1 PCT/EP2005/009148 EP2005009148W WO2007016950A1 WO 2007016950 A1 WO2007016950 A1 WO 2007016950A1 EP 2005009148 W EP2005009148 W EP 2005009148W WO 2007016950 A1 WO2007016950 A1 WO 2007016950A1
Authority
WO
WIPO (PCT)
Prior art keywords
food composition
dietary supplementation
dose
alcohol
supplementation according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/009148
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English (en)
Inventor
Markus Graf V. Matuschka-Greiffenclau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2006278823A priority Critical patent/AU2006278823B2/en
Priority to JP2008523251A priority patent/JP5371428B2/ja
Priority to ES06762860T priority patent/ES2386460T3/es
Priority to EA200800427A priority patent/EA012753B1/ru
Priority to AT06762860T priority patent/ATE554663T1/de
Priority to PCT/EP2006/007466 priority patent/WO2007017139A1/fr
Priority to KR1020077028054A priority patent/KR101562271B1/ko
Priority to CA2611389A priority patent/CA2611389C/fr
Priority to PT06762860T priority patent/PT1909600E/pt
Priority to DK06762860.2T priority patent/DK1909600T3/da
Priority to PL06762860T priority patent/PL1909600T3/pl
Priority to UAA200800602A priority patent/UA94713C2/uk
Priority to EP06762860A priority patent/EP1909600B1/fr
Priority to SI200631337T priority patent/SI1909600T1/sl
Priority to US11/997,127 priority patent/US8580750B2/en
Priority to CN2006800278400A priority patent/CN101232822B/zh
Priority to HRP20120489TT priority patent/HRP20120489T1/hr
Priority to HK08110628.1A priority patent/HK1117709B/en
Publication of WO2007016950A1 publication Critical patent/WO2007016950A1/fr
Anticipated expiration legal-status Critical
Priority to JP2013091972A priority patent/JP5785581B2/ja
Priority to US14/058,388 priority patent/US9402849B2/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention is directed to a composition, in particular a food composition, or dietary supplementation, which is active in respect to a reduction of alcohol induced rise of neurodegenerative disease including late-onset Alzheimer's disease.
  • the invention is directed to a composition affecting the moderation of alcohol degradation process within the human body.
  • an object of the present invention is to achieve solutions which provide a reduction of the rise of alcohol induced neurodegenerative disease including late-onset Alzheimer's disease in connection with the consumption of alcohol, in particular for people with a predisposition towards rapid alcohol degradation and subsequent accumulation of acetaldehyde due to a genetic polymorphism of human acetaldehyde-dehydrogenase enzym.
  • the present invention particularly solves the problem of a long impact of an accumulation of acetaldehyde after rapid alcohol degradation i.e. alcohol metabolism as may occur in most people of Non-Caucasian type genetic structure.
  • the particular food composition or dietary supplementation is considered to be appropriate to reduce a peak of excess acetaldehyde entering the blood stream and is intended to lower the risk of damage to vital organs and functions of the human body.
  • Oxidative stress and the following lipid peroxidation caused by oxidants, such as reactive oxygen species, are reported to play an important role in the pathogenesis of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease , and cerebral ischemia .
  • Ethanol taken into the body is eliminated by its oxidation.
  • Ethanol (CH3CH2OH) is first metabolised to acetaldehyde (CH3CHO) by alcohol dehydrogenase (ADH), and then acetaldehyde (CH3CH0) is further metabolised to acetic acid (CH3C00H) by aldehyde dehydrogenase (ALDH).
  • the first metabolite of orally ingested alcohol, acetaldehyde is a highly reactive molecule with oxidative activity, and has a cytotoxic effects and modifies proteins in the cells, leading to their dysfunction.
  • Acetaldehyde is thus thought to be the cause of several alcohol- induced neuronal changes.
  • Most of acetaldehyde generated during alcohol metabolism is promptly eliminated by ALDH2, the low Km ALDH.
  • ALDH2 has a polymorphism and its mutant ALDH2*2 allele encodes a catalitically inactive subunit
  • ALDH2*2 is prevalent in Asians and has not been found in Caucasians and Africans, who absolutely have active ALDH2*1 allele.
  • ALDH2 activity of ALDH2* 1/2*2 heterozygotes is only 6% of normal ALDH2* 1/2*1 homozygotes.
  • Deficiency of ALDH2 activity is associated with increased the risk of cancer and therefore acetaldehyde is regarded as a carcinogen.
  • the supplement mix according to the invention accelerates the disappearance of alcohol and acetaldehyde after drinking in not only ALDH2* 1/2*1 homozygotes but ALDH2* 1/2*2 heterozygotes.
  • This supplement the is the first mixture ever known, which effectively accelerates alcohol metabolism. Therefore, the supplement according to the invention is expected to decrease the risk of late-onset Alzheimer's disease, if any of other neurodegenerative diseases, for alcohol drinkers with ALDH2*2 allele.
  • the niacin-fraction (Vitamin B3) included in the composition functions as nicotinamide adenine dinucleotide (NAD), which is effective towards a coenzyme to alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH).
  • NAD nicotinamide adenine dinucleotide
  • ADH alcohol dehydrogenase
  • ADH alcohol dehydrogenase
  • ADH aldehyde dehydrogenase
  • the composition also includes Pantotheic acid.
  • Pantotheic acid functions as coenzyme A (CoA), which is considered necessary to metabolize acetic acid.
  • Acetic acid is activated in conjugation with CoA to form acetyl-CoA, which is metabolized in TCA cycle.
  • elimination of a product (acetic acid) is effective towards an acceleration of the metabolism of a substrate (acetaldehyde).
  • this food composition or supplements should be taken about 5 minutes prior to consumption of alcohol and in case of high alcohol consumption again whilst consuming alcohol.
  • the mass of the food composition taken by the consumer should be in the range of about 70 to 120% of the mass of the alcohol included in the consumed drinks.
  • a standard dose might include about 10. Og dextrose, l.Og Vitamin C, 1.5g L-glutamine, 500mg cysteine, 40mg riboflavin, 100 mg succinic acid, 100 mg fumaric acid, 60mg coenzyme QlO, and about 10 mg Niacin (Vitamin B3).
  • the relation of the components of the composition is oriented towards the above given relation.
  • the overall dosage may be adapted to the body mass weight of the consumer.
  • the particular food composition, or dietary supplementation is intended to prevent too much acetaldehyde passing into the mitochondrial matrix and to suppress self- blockade of the enzymatic activity of ALDH and thus facilitate its the decomposition of acetaldehyde.
  • the physiological risks in connection with alcohol consumption may therefore be significantly reduced by the use of the food composition according to the present invention, as this food composition or dietary supplementation facilitates in a synergetic manner an early decrease of the level of acetaldehyde after drinking and simultaneously provides a protective effect in respect of the suppression of the generation of free radicals.
  • Said food composition or dietary supplementation is preferably in such a form, preferably as ingredients of a kind of aperitif, that it allows the food composition to be consumed within a restaurant or a bar prior to consuming alcoholic drinks.
  • a dosage for a person with a body weight of about 80 kg includes a dextrose fraction of approx. 75%, wherein the said dosage may have an overall weight of about 10 to 15, preferably 13.3g.
  • Such a dosage is to provide a considerable moderation in degrading about 18ml alcohol.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same, includes a dextrose fraction of about 75.2 mass%, i.e. a quantity of dextrose in the range from 7.2 to 12.8g, preferably 10.0 g within a dose of 13,3g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a Vitamin C fraction of about 7.5 mass% i.e a quantity of Vitamin C in the range from 0.78 to 1.18 g, preferably 1.Og, within a dose of 13.3g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a L-glutamine fraction of about 11.27 mass%, i.e. a quantity of said L-glutamine fraction in the range from 1.23 to 1.7 g, preferably 1.5g, within a dose of 13.3g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a cysteine fraction of about 3.76 mass%, i.e. a quantity of said cysteine fraction in the range from 460 to 540 mg, preferably 500mg, within a dose of 13.3 g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a riboflavin fraction of about 0.30 mass% i.e. a quantity of said riboflavin in the range from 32 to 48 mg, preferably 40mg, within a dose of 13.3g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a succinic acid (Bernsteinsaure) fraction of about 0.752 mass%, i.e. a quantity of said succinic acid in the range from 90 to 110 mg, preferably lOOmg, within a dose of 133g.
  • a succinic acid Boesteinsaure
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a fumaric acid (Fumarsaure) fraction of about 0.752 mass%, i.e. a quantity of said fumaric acid in the range from 90 to 110 mg, preferably lOOmg, within a dose of 13.3g.
  • a fumaric acid Frumarsaure
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same includes a coenzyme fraction of about 0,451 mass%, i.e. a quantity of said coenzyme fraction in the range from 50 to 70 mg, preferably 60mg, within a dose of 13.3g.
  • the food composition or dietary supplementation is preferably constituted in a manner wherein a dosage of same is in the form of tablets.
  • each tablet is so shaped and dimensioned that it allows said tablet to be easily swallowed.
  • said tablets are in such a form that one dosage includes a plurality of those tablets.
  • the tablets may be accommodated within a dosage receptacle which includes a number of those tablets. It is possible for the food composition to be in the form of small tablets or balls, and to keep same in a small tube, while the volume of the food composition taken by the consumer can be determined with respect to the volume of alcohol which is expected to be consumed.
  • the food composition or dietary supplementation may also be in a form similar to sugar-cubes, or might be in the form of cryopowder.
  • the food composition or dietary supplementation may be separated into separate subunits. It is possible to provide one unit, for example a capsule including the Vitamin C fraction, cysteine, riboflavin, succinic acid, fumaric acid and coenzyme QlO, whilst most of the dextrose fraction is kept in separate units, capsules, tablets or the like.
  • the food-composition or dietary supplementation may also be in the form of a liquid, in particular a sirup-type liquid. It is possible to provide the food composition in the appearance of a soft drink in a small bottle.
  • Glucose is rapidly oxidised in the cytosol of liver cells using the same cytosol NAD+ pool used by ethanol to be converted into acetaldehyde. Because the amount of cytosolic NAD+ is limited and can only constantly be reproduced from NADH+H much less acetaldehyde accumulates.
  • the second achievement is also believed to be achieved by the intake of a large dose of glucose.
  • Glucose augments the enzymatic activity of ADH as well as of ALDH.
  • a large glucose load occurs in the cytosol of liver cells then there is no possibility that the acetaldehyde reaches levels which could lead to inactivation of ALDH or to mitochondrial destruction.
  • Riboflavin will quickly be transformed to FMN, which together with coenzyme Qi 0 is the determining substance for the speed of the reoxidation of NADH+H + to NAD + in the mitochondrial matrix.
  • Acetaldehyde needs NAD+ when it is metabolised to acetic acid.
  • NAD + is transformed into NADH+H + .
  • NADH+H + has to be re-transformed into NAD + to serve again for acetaldehyde decomposition.
  • coenzyme Qio also makes also sense because its level decreases in the human body with progressing age.
  • the activation of the Krebs (citrate) cycle is believed to be achieved by the inclusion of succinic acid and fumaric acid. Both substances activate the second half of the citrate cycle and thereby activate the aerobic oxidation process in mitochondria.
  • L-glutamine helps to speed up the mitochondria-cytosolic malate- asparate shuttle, which plays a key role in the course of intoxication by acetaldehyde. It also speeds up the succinate oxidation process by preventing oxalic and acetic inhibition of succinate dehydrogenase.
  • cysteine Ascorbic acid and also of L-glutamine.
  • Cysteine should provide a strong anti-oxidant effect as well as ascorbic acid.
  • the human body transforms cysteine to gluthatione which specially protects against the toxic effects of acetaldehyde. To reach an optimal level of gluthatione and to avoid cysteine being transformed to cystine, it is important to combine cysteine with glutamine and give twice as much ascorbic acid as cysteine.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition, notamment une composition alimentaire, ou bien un complément diététique qui est actif en matière de support et/ou de modération d’un processus de dégradation d’alcool dans le corps humain. La présente invention concerne en particulier le problème de dégradation rapide d’alcool c’est-à-dire le métabolisme de l’alcool tel qu’il peut se produire chez la plupart des sujets de structure génétique de type non caucasien. Dans cette perspective, un objet de la présente invention entend proposer des solutions permettant de réduire le stress physiologique lié à la consommation d’alcool notamment chez les sujets ayant une prédisposition à une dégradation rapide de l’alcool. Selon la présente invention cet objet est satisfait par une composition alimentaire ou bien un complément diététique comprenant les substances suivantes: niacine, dextrose, Vitamine C, Cystéine de L-glutamine, riboflavine, acide succinique, acide fumarique, et coenzyme Q 10, toutes les substances dans les doses adéquates du point de vue physiologique notamment. La composition permet de réduire les maladies neurodégénératives induites par l’alcool.
PCT/EP2005/009148 2005-07-29 2005-08-24 Composition réduisant les risques de maladie neurodégénérative induite par l’alcool Ceased WO2007016950A1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
PT06762860T PT1909600E (pt) 2005-07-29 2006-07-27 Composição para moderar o metabolismo do álcool e para reduzir o risco de doenças induzidas pelo álcool
PL06762860T PL1909600T3 (pl) 2005-07-29 2006-07-27 Kompozycja spowalniająca metabolizm alkoholu i ograniczająca ryzyko chorób wywołanych alkoholem
ES06762860T ES2386460T3 (es) 2005-07-29 2006-07-27 Composición para moderar el metabolismo del alcohol y para reducir el riesgo de enfermedades inducidas por el alcohol
EA200800427A EA012753B1 (ru) 2005-07-29 2006-07-27 Композиция для сдерживания алкогольного метаболизма и для уменьшения риска заболеваний, вызванных алкоголем
AT06762860T ATE554663T1 (de) 2005-07-29 2006-07-27 Zusammensetzung zur steuerung des alkohol metabolismus und zur reduktion des risikos von alkoholbedingten krankheiten
PCT/EP2006/007466 WO2007017139A1 (fr) 2005-07-29 2006-07-27 Composition destinée à modérer le métabolisme de l’alcool et à réduire le risque de maladies induites par l’alcool
KR1020077028054A KR101562271B1 (ko) 2005-07-29 2006-07-27 알콜대사를 완화하고 알콜유도성 질환의 위험을 감소하기위한 조성물
EP06762860A EP1909600B1 (fr) 2005-07-29 2006-07-27 Composition destinée à modérer le métabolisme de l'alcool et à réduire le risque de maladies induites par l'alcool
JP2008523251A JP5371428B2 (ja) 2005-07-29 2006-07-27 アルコール代謝を和らげる、およびアルコール誘発性疾患のリスクを減少させるための組成物
DK06762860.2T DK1909600T3 (da) 2005-07-29 2006-07-27 Sammensætning til moderering af alkoholmetabolisme og til at reducere risikoen for alkoholforårsagede sygdomme
UAA200800602A UA94713C2 (uk) 2005-07-29 2006-07-27 Композиція для стримування метаболізму алкоголю та для зменшення ризику спричинених алкоголем захворювань
AU2006278823A AU2006278823B2 (en) 2005-07-29 2006-07-27 Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases
CA2611389A CA2611389C (fr) 2005-07-29 2006-07-27 Composition destinee a moderer le metabolisme de l'alcool et a reduire le risque de maladies induites par l'alcool
SI200631337T SI1909600T1 (sl) 2005-07-29 2006-07-27 Zmes za nadzor metabolizma alkohola in za zmanjšanje nevarnosti z alkoholom induciranih bolezni
US11/997,127 US8580750B2 (en) 2005-07-29 2006-07-27 Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases
CN2006800278400A CN101232822B (zh) 2005-07-29 2006-07-27 用于减缓乙醇代谢和用于降低乙醇诱导的疾病风险的组合物
HRP20120489TT HRP20120489T1 (hr) 2005-07-29 2006-07-27 Pripravak za ublažavanje metabolizma alkohola i za smanjivanje rizika od bolesti uzrokovanih alkoholom
HK08110628.1A HK1117709B (en) 2005-07-29 2006-07-27 Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases
JP2013091972A JP5785581B2 (ja) 2005-07-29 2013-04-25 アルコール代謝を和らげる、およびアルコール誘発性疾患のリスクを減少させるための組成物
US14/058,388 US9402849B2 (en) 2005-07-29 2013-10-21 Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05016567 2005-07-29
EPEP05016567 2005-07-29

Publications (1)

Publication Number Publication Date
WO2007016950A1 true WO2007016950A1 (fr) 2007-02-15

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Application Number Title Priority Date Filing Date
PCT/EP2005/009148 Ceased WO2007016950A1 (fr) 2005-07-29 2005-08-24 Composition réduisant les risques de maladie neurodégénérative induite par l’alcool

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012095509A1 (fr) * 2011-01-14 2012-07-19 Tima Foundation Composition visant à accélérer le métabolisme de l'alcool et à réduire le risque de maladies induites par l'alcool
EP2594141A1 (fr) * 2011-11-15 2013-05-22 TIMA Foundation Composition pour la protection contre les effets d'endommagement cellulaire
WO2013072441A1 (fr) * 2011-11-15 2013-05-23 Tima Foundation Composition pour la protection contre des effets qui endommagent les cellules

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP0652012A1 (fr) * 1989-03-27 1995-05-10 Albert Naito Combinaison de sucres avec des acides aminés et autres composés
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Cited By (6)

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WO2012095509A1 (fr) * 2011-01-14 2012-07-19 Tima Foundation Composition visant à accélérer le métabolisme de l'alcool et à réduire le risque de maladies induites par l'alcool
EP2594141A1 (fr) * 2011-11-15 2013-05-22 TIMA Foundation Composition pour la protection contre les effets d'endommagement cellulaire
WO2013072441A1 (fr) * 2011-11-15 2013-05-23 Tima Foundation Composition pour la protection contre des effets qui endommagent les cellules
CN104053368A (zh) * 2011-11-15 2014-09-17 蒂马基金会 抵御细胞损伤效应的组合物
JP2014533295A (ja) * 2011-11-15 2014-12-11 ティーマ ファウンデーション 細胞傷害作用からの防御のための組成物
US9089548B2 (en) 2011-11-15 2015-07-28 Tima Foundation Composition for protection against cell-damaging effects

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