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WO2007014054A3 - Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 - Google Patents

Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 Download PDF

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Publication number
WO2007014054A3
WO2007014054A3 PCT/US2006/028419 US2006028419W WO2007014054A3 WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3 US 2006028419 W US2006028419 W US 2006028419W WO 2007014054 A3 WO2007014054 A3 WO 2007014054A3
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WO
WIPO (PCT)
Prior art keywords
benzenesulfonamide
inhibitor
chemokine receptor
ccr2 chemokine
ccr2
Prior art date
Application number
PCT/US2006/028419
Other languages
English (en)
Other versions
WO2007014054A2 (fr
Inventor
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
Original Assignee
Glaxo Group Limted
Carl Brooks
Pamela A Cleary
Krista B Goodman
Simon Peace
Joanne Philp
Clark A Sehon
Christian Smethurst
Stephen Paul Watson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515194A external-priority patent/GB0515194D0/en
Priority claimed from GB0519492A external-priority patent/GB0519492D0/en
Application filed by Glaxo Group Limted, Carl Brooks, Pamela A Cleary, Krista B Goodman, Simon Peace, Joanne Philp, Clark A Sehon, Christian Smethurst, Stephen Paul Watson filed Critical Glaxo Group Limted
Publication of WO2007014054A2 publication Critical patent/WO2007014054A2/fr
Publication of WO2007014054A3 publication Critical patent/WO2007014054A3/fr

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    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I): ou un sel acceptable sur le plan pharmaceutique, un solvate ou une combinaison de ceux-ci, ainsi que des compositions de procédés d'utilisation de ces composés, R1, R2, R3 et m y étant décrits.
PCT/US2006/028419 2005-07-22 2006-07-21 Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 WO2007014054A2 (fr)

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US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7932252B2 (en) 2004-05-12 2011-04-26 Chemocentryx, Inc. Aryl sulfonamides
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
EP2049515B1 (fr) 2006-07-14 2011-01-26 ChemoCentryx, Inc. Triazolyl pyridyl benzènesulfonamides en tant que modulateurs du ccr2 ou ccr9 pour le traitement l'athérosclérose
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
ES2376668T3 (es) 2006-09-05 2012-03-15 Kyowa Hakko Kirin Co., Ltd. Derivado de imidazol.
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
KR101849560B1 (ko) 2007-07-12 2018-04-17 케모센트릭스, 인크. 염증의 치료를 위한 ｃｃｒ2 조절물질로서 융합된 헤테로아릴 피리딜과 페닐 벤젠술폰아마이드
EP2204366A1 (fr) * 2008-12-19 2010-07-07 Bayer CropScience AG Pyridazinones substitués par phényle agissant en tant qu'herbicide et insecticide
WO2011051198A2 (fr) 2009-10-30 2011-05-05 Bayer Cropscience Ag Dérivés de pyridine en tant qu'agents phytoprotecteurs
EP2588465B1 (fr) 2010-06-30 2017-01-25 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
EP2791121B1 (fr) * 2011-12-12 2016-08-03 Allergan, Inc. Dérivés de benzisothiazol-3(1h)-one-5-sulfonyle en tant que modulateurs de récepteur de chimiokine
US9035071B2 (en) * 2011-12-27 2015-05-19 Allergan, Inc. Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response
CN104066731B (zh) 2011-12-27 2016-06-15 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
JP6494240B2 (ja) * 2013-11-04 2019-04-03 ファイザー・インク カリケアマイシン誘導体を合成するための中間体および方法
KR102754341B1 (ko) 2016-11-23 2025-01-13 케모센트릭스, 인크. 국소 분절 사구체경화증의 치료 방법
CN111479805B (zh) * 2017-08-29 2024-08-13 罗格斯新泽西州立大学 治疗性吲唑
EP3694504A4 (fr) 2017-10-11 2021-07-14 ChemoCentryx, Inc. Traitement de la glomérulosclérose segmentaire focale avec des antagonistes du ccr2
EP4157249A4 (fr) * 2020-05-29 2024-07-24 Novomedix, LLC Biarylsulfonamides et compositions pharmaceutiques associées, et leur utilisation pour le traitement de maladies pulmonaires fibrotiques
IT202200021522A1 (it) * 2022-10-19 2024-04-19 Pirelli Composizioni elastomeriche per pneumatici comprendenti nuovi agenti funzionalizzanti reticolanti, mescole elastomeriche e pneumatici che li comprendono

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