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WO2007012984A3 - Process of producing bepromoline - Google Patents

Process of producing bepromoline Download PDF

Info

Publication number
WO2007012984A3
WO2007012984A3 PCT/IB2006/003362 IB2006003362W WO2007012984A3 WO 2007012984 A3 WO2007012984 A3 WO 2007012984A3 IB 2006003362 W IB2006003362 W IB 2006003362W WO 2007012984 A3 WO2007012984 A3 WO 2007012984A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
bepromoline
producing
hydrogen gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/003362
Other languages
French (fr)
Other versions
WO2007012984A2 (en
Inventor
Beat Weber
Stefan Rosenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma SA
Original Assignee
Galderma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0613307A priority Critical patent/BRPI0613307B8/en
Priority to ES06820980T priority patent/ES2399245T3/en
Priority to CA2616160A priority patent/CA2616160C/en
Priority to EP06820980A priority patent/EP1912961B1/en
Priority to SI200631523T priority patent/SI1912961T1/en
Priority to DK06820980.8T priority patent/DK1912961T3/en
Priority to PL06820980T priority patent/PL1912961T3/en
Application filed by Galderma SA filed Critical Galderma SA
Publication of WO2007012984A2 publication Critical patent/WO2007012984A2/en
Publication of WO2007012984A3 publication Critical patent/WO2007012984A3/en
Anticipated expiration legal-status Critical
Priority to US12/010,635 priority patent/US7795425B2/en
Priority to US12/858,273 priority patent/US8242268B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention refers to a process of manufacturing a compound of formula (Ia), said process comprising: (i) contacting a compound of formula (III) with a compound of formula (IV) in the presence of a palladium catalyst, methanol and hydrogen gas, said step (i) being conducted preferably under basic conditions with acetic acid added once the consumption of the hydrogen gas has ceased.
PCT/IB2006/003362 2005-07-28 2006-07-27 Process of producing bepromoline Ceased WO2007012984A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES06820980T ES2399245T3 (en) 2005-07-28 2006-07-27 Procedure to produce bepromoline
CA2616160A CA2616160C (en) 2005-07-28 2006-07-27 Process of producing bepromoline
EP06820980A EP1912961B1 (en) 2005-07-28 2006-07-27 Process of producing bepromoline
SI200631523T SI1912961T1 (en) 2005-07-28 2006-07-27 Process of producing bepromoline
DK06820980.8T DK1912961T3 (en) 2005-07-28 2006-07-27 Process for the preparation of bepromolin
BRPI0613307A BRPI0613307B8 (en) 2005-07-28 2006-07-27 manufacturing processes for a compound
PL06820980T PL1912961T3 (en) 2005-07-28 2006-07-27 Process of producing bepromoline
US12/010,635 US7795425B2 (en) 2005-07-28 2008-01-28 Production of bepromoline
US12/858,273 US8242268B2 (en) 2005-07-28 2010-08-17 Production of bepromoline

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291611A EP1749826A1 (en) 2005-07-28 2005-07-28 Process of producing bepromoline
EP05291611.1 2005-07-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/010,635 Continuation US7795425B2 (en) 2005-07-28 2008-01-28 Production of bepromoline

Publications (2)

Publication Number Publication Date
WO2007012984A2 WO2007012984A2 (en) 2007-02-01
WO2007012984A3 true WO2007012984A3 (en) 2007-06-14

Family

ID=35064906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003362 Ceased WO2007012984A2 (en) 2005-07-28 2006-07-27 Process of producing bepromoline

Country Status (12)

Country Link
US (2) US7795425B2 (en)
EP (2) EP1749826A1 (en)
AR (1) AR054873A1 (en)
BR (1) BRPI0613307B8 (en)
CA (1) CA2616160C (en)
CY (1) CY1113779T1 (en)
DK (1) DK1912961T3 (en)
ES (1) ES2399245T3 (en)
PL (1) PL1912961T3 (en)
PT (1) PT1912961E (en)
SI (1) SI1912961T1 (en)
WO (1) WO2007012984A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749826A1 (en) * 2005-07-28 2007-02-07 Galderma S.A. Process of producing bepromoline
EP1935889A1 (en) * 2006-12-21 2008-06-25 Galderma S.A. Process of producing amorolfine
ITFI20090032A1 (en) * 2009-02-20 2010-08-21 Synteco S P A Prodotti Di Sintesi Per L Ind INDUSTRIAL PRODUCTION PROCESS OF CHLORIDATED AMOROLFIN
WO2011066735A1 (en) * 2009-12-01 2011-06-09 Zhejiang Hisoar Pharmaceutical Co., Ltd An Amorolfine HCl Crystal and the Preparation thereof
CN102887872B (en) * 2011-12-30 2015-06-24 浙江海翔药业股份有限公司 Method for preparing amorolfine hydrochloride
CN109232458A (en) * 2018-06-15 2019-01-18 南通常佑药业科技有限公司 A kind of preparation method of chirality morpholinium compound

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046280A (en) * 1955-11-24 1962-07-24 Philips Corp Primary, secondary and tertiary amines having a spasmolytic effect and method of producing these compounds
US4202894A (en) * 1976-11-22 1980-05-13 Hoffmann-La Roche Inc. Piperidines morpholines, etc., and fungicidal compositions thereof
FR2463767A1 (en) * 1979-08-17 1981-02-27 Hoffmann La Roche NOVEL CIS-4- (3-PHENYL-2-METHYL-PROPYL) -2,6-DIMETHYL-MORPHOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME
GB1591267A (en) * 1976-12-15 1981-06-17 Basf Ag Morpholine derivatives and their use as fungicides
US4283534A (en) * 1979-04-11 1981-08-11 Basf Aktiengesellschaft Reductive alkylation of nitrogen heterocycles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749826A1 (en) * 2005-07-28 2007-02-07 Galderma S.A. Process of producing bepromoline
EP1935889A1 (en) * 2006-12-21 2008-06-25 Galderma S.A. Process of producing amorolfine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046280A (en) * 1955-11-24 1962-07-24 Philips Corp Primary, secondary and tertiary amines having a spasmolytic effect and method of producing these compounds
US4202894A (en) * 1976-11-22 1980-05-13 Hoffmann-La Roche Inc. Piperidines morpholines, etc., and fungicidal compositions thereof
GB1591267A (en) * 1976-12-15 1981-06-17 Basf Ag Morpholine derivatives and their use as fungicides
US4283534A (en) * 1979-04-11 1981-08-11 Basf Aktiengesellschaft Reductive alkylation of nitrogen heterocycles
FR2463767A1 (en) * 1979-08-17 1981-02-27 Hoffmann La Roche NOVEL CIS-4- (3-PHENYL-2-METHYL-PROPYL) -2,6-DIMETHYL-MORPHOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME
EP0024334A1 (en) * 1979-08-17 1981-03-04 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Morpholine derivatives, process for their production, pharmaceutical preparations containing these derivatives

Also Published As

Publication number Publication date
EP1912961B1 (en) 2012-12-05
US7795425B2 (en) 2010-09-14
SI1912961T1 (en) 2013-04-30
CA2616160A1 (en) 2007-02-01
CA2616160C (en) 2014-02-11
ES2399245T3 (en) 2013-03-26
BRPI0613307B8 (en) 2021-05-25
BRPI0613307A2 (en) 2010-12-28
PL1912961T3 (en) 2013-04-30
US20080269483A1 (en) 2008-10-30
EP1912961A2 (en) 2008-04-23
BRPI0613307B1 (en) 2021-04-06
WO2007012984A2 (en) 2007-02-01
DK1912961T3 (en) 2013-02-11
CY1113779T1 (en) 2016-07-27
AR054873A1 (en) 2007-07-25
US8242268B2 (en) 2012-08-14
EP1749826A1 (en) 2007-02-07
PT1912961E (en) 2013-02-04
US20100311967A1 (en) 2010-12-09

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