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WO2007011923A2 - Dispositif d'administration de fluide - Google Patents

Dispositif d'administration de fluide Download PDF

Info

Publication number
WO2007011923A2
WO2007011923A2 PCT/US2006/027800 US2006027800W WO2007011923A2 WO 2007011923 A2 WO2007011923 A2 WO 2007011923A2 US 2006027800 W US2006027800 W US 2006027800W WO 2007011923 A2 WO2007011923 A2 WO 2007011923A2
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
chamber
delivery device
piston
fluid delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/027800
Other languages
English (en)
Other versions
WO2007011923A3 (fr
Inventor
John Gordon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microlin LLC
Original Assignee
Microlin LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microlin LLC filed Critical Microlin LLC
Priority to JP2008521713A priority Critical patent/JP2009501574A/ja
Priority to EP06787673A priority patent/EP1904746A2/fr
Publication of WO2007011923A2 publication Critical patent/WO2007011923A2/fr
Publication of WO2007011923A3 publication Critical patent/WO2007011923A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Definitions

  • FIG. 1 is a plan view of an embodiment of a fluid delivery device.
  • FIG. 2 is a plan view of another embodiment of a fluid delivery device having a master piston and a slave piston.
  • FIG. 3 is a top plan view of still another embodiment of a fluid delivery device having three pistons with varying cross-sectional areas.
  • FIG. 4 is a plan view of yet another embodiment of a fluid delivery device.
  • FIG. 5 is a plan view of yet another embodiment of a fluid delivery device having remote fluid delivery components.
  • the fluid may include a medicament and may be delivered in an implantable device to a part of the human body of a patient, such as into a part of the human body or onto a part of the human body. Some embodiments may also, or alternatively, provide for suction of a fluid, such as from a part of the body to a reservoir or other chamber. In a particular subset of embodiments, the force to drive the fluid may be provided by an electroosmotic pump or gas generation pump. In some embodiments, the fluid delivery rate may be adjusted by varying the resistance of the pump circuit. Some embodiments of the invention may also facilitate suction of a fluid concurrently with the delivery of a medicament or other beneficial fluid.
  • FIG. 1 depicts a fluid delivery device 10.
  • Device 10 includes a fluid power source 20, which is configured to drive a piston 30. Piston 30 is slidably received in fluid chamber 35.
  • Fluid chamber 35 may contain a fluid having a medicament or other beneficial chemical or material.
  • Port 38 is in fluid communication with fluid chamber 35 and is connected with catheter 40.
  • Fluid power source 20 may comprise, for example, an electroosmotic or osmotic engine, or a gas generation cell.
  • that engine may include a first electrode, a second electrode, an ion exchange membrane positioned between the first and second electrodes, and a coupling between the first and second electrodes.
  • the coupling between the electrodes may comprise a resistor or resistors.
  • the res ⁇ stor(s) may be replaceable or adjustable so as to vary the rate at which the electroosmotic engine operates and thereby vary the power conveyed to the piston(s) by simply replacing the resistor with an alternative resistor with the desired properties, or otherwise adjusting the resistance between the electrodes.
  • FIG. 2 another embodiment of a fluid delivery device 100 is depicted.
  • Fluid delivery device 100 also includes a fluid power source 110.
  • Fluid power source may comprise any of the various devices or structures described above.
  • fluid delivery device 100 includes a master piston 120 and a slave piston 130. It should be understood that, whereas a single slave piston is shown in the embodiment of FIG. 2, other embodiments are contemplated in which additional slave pistons are provided. In fact, virtually any number of slave pistons may be provided, limited in number only by logistical and/or practical considerations.
  • Slave piston 130 is coupled to master piston 120 to move in unison with master piston 120.
  • coupling 125 is used to couple master piston 120 to slave piston 130. More specifically, coupling 125 connects piston rod 121 to piston rod 131.
  • Fluid power source 110 is configured to drive the master piston 120, which may be used to deliver a fluid out of drive piston chamber Tl ' l, through port 123, and into catheter 140. As master piston 120 moves in response to the force provided by fluid power source 110, slave piston 130 also moves within slave piston chamber 132.
  • Chambers 122 and 132 are also each sealed with a sealing gland — sealing glands 126 and 136, respectively, so as to allow the piston rods to exit the chambers as the pistons are forced upward (from the view of FIG. 2) while maintaining the chambers as sealed. Any of the chambers discussed herein can be considered examples of means for housing a fluid. Because chambers 122 and 132 are independently fluidly sealed, chamber 132 can deliver a second fluid concurrently with the delivery of the fluid delivered from chamber 122. For example, a second fluid stored in slave piston chamber 132 can be delivered through port 133 and into a second catheter 150. Of course, the fluids delivered from the two chambers may be identical or different, depending upon the application and desired outcome.
  • a partial vacuum or vacuums are created, which can be used for the purpose of providing a suction force through another delivery device or component, such as a catheter.
  • a medicament or other beneficial fluid may be driven by the driving piston and/or suctioned by another piston(s) concurrently.
  • a medicament or other beneficial fluid may be driven by the driving piston and/or an undesirable fluid may suctioned from a site by another piston(s) concurrently.
  • the suction force may be used to relieve pressure and/or remove toxins from a body site.
  • fluid delivery device 100 includes a third catheter 160 positioned on the opposite side of chamber 132 relative to slave piston 130. With respect to chamber 132, device 100 is therefore configured to provide both a driving force to deliver a fluid out of chamber 132 through catheter 150, and a suction force to deliver another fluid into chamber 132 through catheter 160.
  • the driving and suction forces in the embodiment of FIG. 2 are provided simultaneously by the fluid power source 110.
  • Providing a suction feature as disclosed herein may be beneficial if, for example, a fluid needs to be removed from a portion of a patient's body over an extended period of time using, for example, an implanted device.
  • one or more of the slave piston chambers may have one or more vents used instead of a suction catheter(s). Such vents will allow fluids to be delivered from the slave piston chambers without generating a partial vacuum.
  • different beneficial fluids may also be delivered at different rates as desired. More specifically, the rates of delivery may vary proportionally to one other by providing pistons and chambers with varying cross-sectional areas. Each of the various fluids to be delivered may therefore be associated with a different-sized piston in accordance with the desired delivery rate for each particular fluid. As mentioned above, each of the various pistons may be driven from the same driver — i.e., a single fluid power source connected to a single master piston.
  • Fluid delivery device 200 includes three separate chambers, each of which corresponds with a separate piston.
  • drive piston chamber 232 has a cross-sectional area in between that of slave piston chambers 222 and 242. The rate of fluid delivery from each of the chambers will therefore be greatest for chamber 242 through catheter 260, less for chamber 232 through catheter 250, and least for chamber 222 through catheter 240.
  • a fluid power source such as an electroosmotic pump, as previously disclosed.
  • Fluid delivery device 300 is again powered by a fluid power source 310.
  • Fluid power source 310 is positioned and configured to drive master piston 320, which is positioned within chamber 322.
  • Master piston 320 is connected with piston rod 321.
  • Two slave pistons — slave piston 330 and slave piston 340 — are coupled with master piston 320.
  • Slave piston 330 is positioned within chamber 332 and slave piston 340 is positioned within chamber 342.
  • Piston rods 331 and 341 are each coupled to a coupling bar 336 which is, in turn, coupled to piston rod 321 to thereby couple master piston 320 with each of the respective slave pistons.
  • Coupling bar 336, and coupling 125 in the embodiment shown in FIG. 2 are both examples of means for coupling a first driving means to a second driving means.
  • fluid delivery device 300 operates by using the master piston 320 to push slave pistons 330 and 340 downstream of the master piston, rather than to pull them alongside the master piston, as in previously disclosed embodiments.
  • each of the piston chambers in fluid delivery device 300 is configured to hold and deliver a fluid into a catheter.
  • catheter 350 is in fluid communication with chamber 322 and is configured to receive a fluid delivered from chamber 322.
  • catheters 360 and 370 are in fluid communication with, and are configured to receive a fluid delivered from, chambers 332 and 342, respectively.
  • Each of the chambers are also independently fluidly sealed.
  • piston rods 321 , 331 , and 341 are able to pass through their respective chambers — chambers 322, 332, and 342 — due to sealing glands 326, 336, and 346, respectively.
  • chamber 342 (and piston 340) has a greater cross-sectional area than that of chamber 332 (and piston 330).
  • the fluid delivered from chamber 342 will therefore be delivered at a greater rate than that of the fluid from chamber 332.
  • the delivery rates may be further adjusted without constructing a new device by, for example, adjusting the flow of electrons through a circuit associated with the fluid power source.
  • one way of adjusting the flow of electrons through a circuit associated with the fluid power source would be to adjust the resistance between two electrodes in an electroosmotic pump.
  • FIG. 5 depicts a fluid delivery device 400.
  • Fluid delivery device 400 has many of the same components as that of FIG. 2, which are labeled accordingly.
  • fluid delivery device 400 also includes three remote fluid chambers, each of which is hydraulically coupled to one of chambers 122 and 132.
  • Each of the remote chambers is accompanied by a displaceable member and each is also configured to deliver a fluid.
  • Each of the various fluid delivery components is driven by master piston 120 via fluid power source 110.
  • the fluid from one or more of the proximate chambers may be transmitted through tubing to one or more remote fluid containing chambers, such as chambers 442, 452, and 462.
  • Each of chambers 442, 452, and 462 has an associated displaceable member — displaceable members 440, 450, and 460, respectively.
  • These chamber/displaceable member configurations may comprise a cylinder and piston or may comprise a collapsible bag, flexible diaphragm, or the like.
  • displaceable members 440 and 450 both comprise pistons
  • displaceable member 460 comprises a collapsible bag.
  • fluid power source 110 forces piston 120, fluid from chamber 122 is forced into tube 140 via port 123. That fluid is then used to drive remote piston 440, which, in turn, drives another fluid out of chamber 442 and into catheter 448.
  • fluid power source 110 also simultaneously drives slave piston 130. Piston 130 may be used to drive a fluid into tube 160 via port 138 and simultaneously drives a fluid into tube 150 via port 133. As the fluid from chamber 132 enters chamber 462 from tube 160, it causes collapsible bag 460 to collapse and the fluid inside collapsible bag 460 to exit through catheter 468.
  • the fluid from chamber 132 As the fluid from chamber 132 enters chamber 452 from tube 150, it drives remote piston 450, which, in turn, drives another fluid out of chamber 452 and into catheter 458.
  • Several fluid delivery components may thereby be provided with varying delivery rates and/or mechanisms as desired.
  • the delivery rate of the fluid inside chamber 452 from piston 450 will be less than the delivery rate of the fluid inside chamber 442 from piston 440, due to the fact that there are two remote delivery components coupled with chamber 132 and only one with chamber 122.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Reciprocating Pumps (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne des modes de réalisation de systèmes, d'appareils et de procédés destinés à administrer un fluide. Dans un mode de réalisation caractéristique, un dispositif d'administration de fluide (100) comprend un piston maître (120) couplé à au moins un piston esclave (130) en vue de se déplacer à l'unisson avec le piston maître (120). Une source d'énergie fluidique (110), notamment une pompe électro-osmotique, est également fournie, laquelle est configurée de manière à entraîner le piston maître (120). Les divers pistons peuvent être dimensionnés différemment de manière à fournir des taux d'administration qui varient proportionnellement à la différence de taille entre les pistons. Dans certains modes de réalisation, le dispositif d'administration de fluide (100) peut fournir à la fois une force d'entraînement et une force d'aspiration, de sorte qu'un premier fluide puisse être délivré hors d'une chambre (122) alors qu'un second fluide est délivré dans cette chambre (122) ou dans une chambre séparée (132).
PCT/US2006/027800 2005-07-15 2006-07-17 Dispositif d'administration de fluide Ceased WO2007011923A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008521713A JP2009501574A (ja) 2005-07-15 2006-07-17 流体送出装置
EP06787673A EP1904746A2 (fr) 2005-07-15 2006-07-17 Dispositif d'administration de fluide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69970305P 2005-07-15 2005-07-15
US60/699,703 2005-07-15

Publications (2)

Publication Number Publication Date
WO2007011923A2 true WO2007011923A2 (fr) 2007-01-25
WO2007011923A3 WO2007011923A3 (fr) 2007-11-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027800 Ceased WO2007011923A2 (fr) 2005-07-15 2006-07-17 Dispositif d'administration de fluide

Country Status (4)

Country Link
US (1) US20070025869A1 (fr)
EP (1) EP1904746A2 (fr)
JP (1) JP2009501574A (fr)
WO (1) WO2007011923A2 (fr)

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Also Published As

Publication number Publication date
JP2009501574A (ja) 2009-01-22
US20070025869A1 (en) 2007-02-01
WO2007011923A3 (fr) 2007-11-22
EP1904746A2 (fr) 2008-04-02

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