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WO2007011887A3 - Production d'alcaloides de morphinane et de derives de ceux-ci dans des plantes - Google Patents

Production d'alcaloides de morphinane et de derives de ceux-ci dans des plantes Download PDF

Info

Publication number
WO2007011887A3
WO2007011887A3 PCT/US2006/027731 US2006027731W WO2007011887A3 WO 2007011887 A3 WO2007011887 A3 WO 2007011887A3 US 2006027731 W US2006027731 W US 2006027731W WO 2007011887 A3 WO2007011887 A3 WO 2007011887A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
plants
production
morphinan alkaloids
morphinan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/027731
Other languages
English (en)
Other versions
WO2007011887A2 (fr
Inventor
Nestor Apuya
Steven Craig Bobzin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ceres Inc
Original Assignee
Ceres Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceres Inc filed Critical Ceres Inc
Publication of WO2007011887A2 publication Critical patent/WO2007011887A2/fr
Publication of WO2007011887A3 publication Critical patent/WO2007011887A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des compositions et des procédés destinés à produire des composés alcaloïdes, par exemple, des alcaloïdes de morphinane et des dérivés de ceux-ci, dans des plantes. Elle concerne par exemple, une cellule végétale exprimant une enzyme modifiant un alcaloïde de morphinane qui catalyse la synthèse d'un ou plusieurs alcaloïdes de morphinane ou dérivés de ceux-ci.
PCT/US2006/027731 2005-07-18 2006-07-18 Production d'alcaloides de morphinane et de derives de ceux-ci dans des plantes Ceased WO2007011887A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70055805P 2005-07-18 2005-07-18
US60/700,558 2005-07-18

Publications (2)

Publication Number Publication Date
WO2007011887A2 WO2007011887A2 (fr) 2007-01-25
WO2007011887A3 true WO2007011887A3 (fr) 2007-10-04

Family

ID=37669475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027731 Ceased WO2007011887A2 (fr) 2005-07-18 2006-07-18 Production d'alcaloides de morphinane et de derives de ceux-ci dans des plantes

Country Status (1)

Country Link
WO (1) WO2007011887A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598367B2 (en) 2005-06-30 2009-10-06 Ceres, Inc. Early light-induced protein promoters
US7655786B2 (en) 2006-03-15 2010-02-02 E.I. Du Pont De Nemours And Company Gene expression modulating element
CN103270947B (zh) * 2013-03-08 2014-09-03 浙江省农业科学院 一种司牛角组织培养的方法
GB201413899D0 (en) * 2014-08-06 2014-09-17 Johnson Matthey Plc Catalyst and use therof
KR102188926B1 (ko) 2016-07-18 2020-12-10 쌩-고벵 글래스 프랑스 방호 및 패닉방지(antipanic) 특성을 갖는 투명한 방화글레이징
CA3032373A1 (fr) 2016-08-03 2018-02-08 Saint-Gobain Glass France Vitrage transparent, sans eclats, anti-bombardement, dote de proprietes de protection contre l'incendie

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1270727A1 (fr) * 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-0-acétyltransférase et ses derivés
WO2005053382A1 (fr) * 2003-12-02 2005-06-16 Johnson & Johnson Research Pty Limited Modulation de l'activite de cytochrome p-450 reductase dans des plantes de pavot

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1270727A1 (fr) * 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-0-acétyltransférase et ses derivés
WO2005053382A1 (fr) * 2003-12-02 2005-06-16 Johnson & Johnson Research Pty Limited Modulation de l'activite de cytochrome p-450 reductase dans des plantes de pavot

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRUCE ET AL: "Engineering pathways for transformations of morphine alkaloids", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 13, no. 6, June 1995 (1995-06-01), pages 200 - 205, XP005030343, ISSN: 0167-7799 *
RITTER J K ET AL: "Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 265, no. 14, 15 May 1990 (1990-05-15), pages 7900 - 7906, XP002121919, ISSN: 0021-9258 *
WOO HO-HYUNG ET AL: "Altered life cycle in Arabidopsis plants expressing PsUGT1, a UDP-glucuronosyltransferase-encoding gene from pea.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 133, no. 2, October 2003 (2003-10-01), pages 538 - 548, XP002423855, ISSN: 0032-0889 *

Also Published As

Publication number Publication date
WO2007011887A2 (fr) 2007-01-25

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