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WO2007011698A3 - Humanized antibody conjugates and related methods, assays, reagents, and kits - Google Patents

Humanized antibody conjugates and related methods, assays, reagents, and kits Download PDF

Info

Publication number
WO2007011698A3
WO2007011698A3 PCT/US2006/027312 US2006027312W WO2007011698A3 WO 2007011698 A3 WO2007011698 A3 WO 2007011698A3 US 2006027312 W US2006027312 W US 2006027312W WO 2007011698 A3 WO2007011698 A3 WO 2007011698A3
Authority
WO
WIPO (PCT)
Prior art keywords
humanized antibody
kits
reagents
antibody conjugates
related methods
Prior art date
Application number
PCT/US2006/027312
Other languages
French (fr)
Other versions
WO2007011698A2 (en
Inventor
Linda-Marie Anderson-Mauser
Mary Margaret Foltz
Robert John Dwyer
Original Assignee
Bayer Healthcare Llc
Linda-Marie Anderson-Mauser
Mary Margaret Foltz
Robert John Dwyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc, Linda-Marie Anderson-Mauser, Mary Margaret Foltz, Robert John Dwyer filed Critical Bayer Healthcare Llc
Priority to EP06787249A priority Critical patent/EP1922412A4/en
Publication of WO2007011698A2 publication Critical patent/WO2007011698A2/en
Publication of WO2007011698A3 publication Critical patent/WO2007011698A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides synthetically and recombinantly-derived humanized antibody conjugates and related methods, diagnostic assays, reagents, and kits. In one embodiment, the invention provides humanized antibody conjugates comprising a human immunoglobulin fragment which is bound by a cross-linking functional group to a non-human antibody fragment (e.g., a non-human monoclonal antibody fragment) comprising an antigen-binding amino acid sequence.
PCT/US2006/027312 2005-07-15 2006-07-14 Humanized antibody conjugates and related methods, assays, reagents, and kits WO2007011698A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06787249A EP1922412A4 (en) 2005-07-15 2006-07-14 HUMANIZED ANTIBODY CONJUGATES AND CORRESPONDING METHODS, TESTS, REAGENTS AND KITS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69961805P 2005-07-15 2005-07-15
US60/699,618 2005-07-15
US70836105P 2005-08-31 2005-08-31
US60/708,361 2005-08-31

Publications (2)

Publication Number Publication Date
WO2007011698A2 WO2007011698A2 (en) 2007-01-25
WO2007011698A3 true WO2007011698A3 (en) 2007-06-28

Family

ID=37669378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027312 WO2007011698A2 (en) 2005-07-15 2006-07-14 Humanized antibody conjugates and related methods, assays, reagents, and kits

Country Status (2)

Country Link
EP (1) EP1922412A4 (en)
WO (1) WO2007011698A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858752B2 (en) 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
EA200970834A1 (en) * 2007-03-06 2010-04-30 Рибовакс Байотекнолоджиз С.А. ANTIBODIES TO THE VIRUS VIRUS
CN103383393B (en) * 2013-06-28 2015-11-25 英科隆生物技术（杭州）有限公司 A kind of quality-control product of alternative patient's positive blood
CN108445224A (en) * 2018-02-26 2018-08-24 王贤俊 A kind of cardic fatty acid binding protein antibody fragment compounded latex particle and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929543A (en) * 1987-05-14 1990-05-29 Boehringer Mannheim Gmbh Process for the determination of an antibody in human body fluids
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6015662A (en) * 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls
US6207815B1 (en) * 1988-10-19 2001-03-27 The Dow Chemical Company Family of high affinity, modified antibodies for cancer treatment
US6303755B1 (en) * 1996-07-11 2001-10-16 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies
US6630292B2 (en) * 2000-04-25 2003-10-07 Fuji Photo Film B.V. Method for producing a silver halide photographic emulsion
US6849259B2 (en) * 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681566A (en) * 1988-10-24 1997-10-28 3I Research Exploitation Limited Antibody conjugates with two or more covalently linked FC regions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929543A (en) * 1987-05-14 1990-05-29 Boehringer Mannheim Gmbh Process for the determination of an antibody in human body fluids
US6207815B1 (en) * 1988-10-19 2001-03-27 The Dow Chemical Company Family of high affinity, modified antibodies for cancer treatment
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6015662A (en) * 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls
US6303755B1 (en) * 1996-07-11 2001-10-16 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies
US6630292B2 (en) * 2000-04-25 2003-10-07 Fuji Photo Film B.V. Method for producing a silver halide photographic emulsion
US6849259B2 (en) * 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1922412A4 *

Also Published As

Publication number Publication date
WO2007011698A2 (en) 2007-01-25
EP1922412A2 (en) 2008-05-21
EP1922412A4 (en) 2009-07-15

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