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WO2007010504A3 - Acid addition salts of isoindoles acting as adrenergic receptor antagonists - Google Patents

Acid addition salts of isoindoles acting as adrenergic receptor antagonists Download PDF

Info

Publication number
WO2007010504A3
WO2007010504A3 PCT/IB2006/052516 IB2006052516W WO2007010504A3 WO 2007010504 A3 WO2007010504 A3 WO 2007010504A3 IB 2006052516 W IB2006052516 W IB 2006052516W WO 2007010504 A3 WO2007010504 A3 WO 2007010504A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid addition
addition salts
isoindoles
acting
receptor antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/052516
Other languages
French (fr)
Other versions
WO2007010504A2 (en
Inventor
Pakala Kumara Savithru Sarma
Gyan Chand Yadav
Harish Niranjan Lal Dorwal
Praful Gupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2007010504A2 publication Critical patent/WO2007010504A2/en
Publication of WO2007010504A3 publication Critical patent/WO2007010504A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Provided herein are acid addition salts of compounds of Formula (I). The acid addition salts of Formula I described herein can be used to treat benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, these compounds can be used to treat lower urinary tract symptoms (LUTS) that may or may not be associated with BPH. Process for preparing the compounds described herein, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof and LUTS that may or may not be associated with BPH are also provided.
PCT/IB2006/052516 2005-07-22 2006-07-21 Acid addition salts of isoindoles acting as adrenergic receptor antagonists Ceased WO2007010504A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1940DE2005 2005-07-22
IN1940/DEL/2005 2005-07-22

Publications (2)

Publication Number Publication Date
WO2007010504A2 WO2007010504A2 (en) 2007-01-25
WO2007010504A3 true WO2007010504A3 (en) 2007-04-05

Family

ID=37517191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/052516 Ceased WO2007010504A2 (en) 2005-07-22 2006-07-21 Acid addition salts of isoindoles acting as adrenergic receptor antagonists

Country Status (1)

Country Link
WO (1) WO2007010504A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936661A (en) * 1982-08-26 1984-02-28 Eisai Co Ltd Carboxylic acid imide derivative, its preparation and drug containing the same
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers
WO2005037282A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2,5-dione derivatives as adrenergic receptor antagonists
WO2005118537A2 (en) * 2004-05-31 2005-12-15 Ranbaxy Laboratories Limited Arylpiperazine derivatives as adrenergic receptor antagonists
WO2006092710A1 (en) * 2005-03-02 2006-09-08 Ranbaxy Laboratories Limited Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936661A (en) * 1982-08-26 1984-02-28 Eisai Co Ltd Carboxylic acid imide derivative, its preparation and drug containing the same
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers
WO2005037282A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2,5-dione derivatives as adrenergic receptor antagonists
WO2005118537A2 (en) * 2004-05-31 2005-12-15 Ranbaxy Laboratories Limited Arylpiperazine derivatives as adrenergic receptor antagonists
WO2006092710A1 (en) * 2005-03-02 2006-09-08 Ranbaxy Laboratories Limited Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione

Also Published As

Publication number Publication date
WO2007010504A2 (en) 2007-01-25

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