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WO2007010579A1 - Dispositif pour administrer des fluides sous forme nebulisee - Google Patents

Dispositif pour administrer des fluides sous forme nebulisee Download PDF

Info

Publication number
WO2007010579A1
WO2007010579A1 PCT/IT2006/000523 IT2006000523W WO2007010579A1 WO 2007010579 A1 WO2007010579 A1 WO 2007010579A1 IT 2006000523 W IT2006000523 W IT 2006000523W WO 2007010579 A1 WO2007010579 A1 WO 2007010579A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
nozzle
cover
duct
order
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2006/000523
Other languages
English (en)
Inventor
Mariano Giaretta
Alberto Rivetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Markos Mefar SpA
Original Assignee
Markos Mefar SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Markos Mefar SpA filed Critical Markos Mefar SpA
Priority to EP06766381A priority Critical patent/EP1909967A1/fr
Publication of WO2007010579A1 publication Critical patent/WO2007010579A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0433—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of gas surrounded by an external conduit of liquid upstream the mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
    • B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle
    • B05B7/2424—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle the carried liquid and the main stream of atomising fluid being brought together downstream of the container before discharge

Definitions

  • the present invention relates to a device for administering fluids in nebulised form (aerosols) via nasal and/or oral channels.
  • nebuliser bulbs are also known in the field of aerosol appliances as "nebuliser bulbs”.
  • Currently known devices for the administration of fluids in nebulised or aerosol form comprise a first body adapted to contain the fluid to be administered, a nozzle adapted to nebulise the fluid by the Venturi effect, a second body or cover detachably engaged with the first body and forming, with the first body and the nozzle, an aerosol particle collection chamber.
  • the second body or cover bears a guide connection, communicating with the collection chamber, in order to convey the nebulised fluid into the user's nasal cavities and to enable a correct position of use.
  • the device configured in this way is connected to a compressor or a like generator of gas or pressurised air needed for the formation of the aerosol.
  • the end of the nozzle adapted to nebulise the fluid is inside the collection chamber in a coaxial position with respect to the connection borne by the cover and at an appropriate distance from the internal mouth of the connection in order to channel the finest particles of the aerosol jet into the nasal/oral cavities and to collect the coarser and peripheral particles on the inner walls of the cover.
  • peripheral particles spread irregularly over the inner walls of the cover or second body forming droplets which slide, under the effect of gravity, along the walls and collect at the base of the nebulisation nozzle and, as a result of the Venturi effect, are nebulised again; the inner walls of the collection chamber are appropriately shaped to promote the flow of fluid to the base of the nozzle.
  • Viscous drugs in practice show a high level of molecular adhesion and therefore tend to adhere more forcefully to the surfaces on which they are deposited; as this physical property facilitates adhesion to the mucous membranes inside the nose, increasing the length of time that it remains in situ and the gradual osmotic absorption of the drug, the administration of drugs in aerosol form is particularly advantageous.
  • higher adhesion levels have the drawback of reducing the quantity of the drug nebulised.
  • the particles of the aerosol jet which are spread on the inner walls of the bulb, in particular on the inner surfaces of the cover, tend to continue to adhere thereto and can slide again into the collection chamber only when large droplets are formed, thereby reducing the quantity of the drug actually administered.
  • a first object of the invention is to provide a device for administering a fluid in nebulised form, via nasal channels, able to maximise the quantity of fluid administered to the user and to reduce to a minimum the quantity of fluid which is not used.
  • a further object of the invention is to provide a device able efficiently to administer particularly viscous fluids.
  • a further object of the invention is to provide a device suited to embodiments of the "throwaway" or disposable type.
  • a further object of the invention is to provide a device which has a smaller number of components and which can be produced in an economically advantageous manner.
  • a further object of the invention is to provide a device having smaller dimensions which is readily portable.
  • Figs. 1 and 2 are perspective views of a first embodiment of the invention respectively prepared for sale and ready for use;
  • Figs. 3 and 4 are exploded views, respectively in elevation and in axial section, of the device of the preceding Figures;
  • Fig. 5 is a view in section of the device assembled for use
  • Figs. 6 and 7 are views in section of a first and a second variant respectively of the device of the invention
  • Fig. 8 is an exploded view in section of a third variant of the device;
  • Fig. 9 is a view in section of a fourth variant of the same device assembled.
  • a device for administering fluids in nebulised form is shown overall by 1 and comprises a bulb 2 in which a collection chamber 3 for the fluid to be nebulised is provided.
  • a duct 4 having a first end 5 which may be connected, in use, to a compressor or like device supplying a flow of pressurised gas via tubing (not shown) extends through the bulb 2, passing through the chamber 3, with a section 6 of the duct projecting therebeyond by a non-negligible amount.
  • An end wall 8 comprising a through hole 9 coaxial with the duct 4 is provided at the end of the section 6.
  • a recess 10 extending up to the end wall 8 is provided at this same end, externally to the duct 4.
  • a cup formation 11 is provided unitary with the duct 4, the external shell 12 of this formation being threaded in order to engage the corresponding threaded inner shell 13 of a cover 14.
  • the cover and cup formation 11, 14 form the collection chamber 3 for the fluid to be nebulised.
  • the cover 14 is rigid with a tubular member 15 able to be fitted as a hood on the duct 4, coaxially thereto but radially spaced so that a space 16 is provided between the outer shell of the duct 4 and the inner shell of the tubular member 15 and extends up to the vicinity of the base 17 of the chamber 3 to form a riser 18 adapted to take up the fluid to be administered in aerosol form.
  • the tubular member is closed, in a similar manner to the duct 4, on the side opposite the base of the chamber 3 by an end wall 19 provided with a through hole 20 coaxial with the hole 9 of the duct 4.
  • the wall 19 is kept spaced from the wall 8 by ribs 19a. This provides a nebulisation nozzle shown overall by 21 and supplied via the riser 18 as a result of the Venturi effect in order to nebulise the treatment fluid in the patient's nasal (or oral) cavity.
  • the cover bears a tubular sleeve 23 extending coaxially to the tubular member 15 beyond the nozzle itself in order form a nasal supply guide.
  • This guide is brought to the nostril and may be partially inserted therein so that all the nebulised fluid is correctly conveyed into the nasal cavity.
  • this guide may be tightly inserted, i.e.
  • At least one passage 26 is provided between the tubular sleeve 23 and the tubular member 15 in order to balance the pressure generated in the nasal cavity with the pressure in the chamber 3 which is in turn balanced in the manner described below with external atmospheric pressure.
  • the nozzle 21 supplies nebulised fluid with a substantially conical configuration of angle A.
  • the geometry and extension of the tubular sleeve 23 and of the nozzle are selected such that the nebulisation cone of the nozzle is projected entirely externally to the nasal supply guide, directly into the patient's nasal cavity.
  • the cover 14 is lastly provided with a raised edge 24, concentric with the sleeve 23 externally thereto and provided with through openings 25. This helps to collect and return any nebulised fluid which may have dripped outside the sleeve 23 to the chamber 3 for further supply.
  • the return to the chamber 3 is facilitated by the depression generated as a result of the Venturi effect in this chamber by the nozzle, comprising a continuous inlet of air into the chamber 3 via the openings 25.
  • the latter are also adapted to balance the pressure in the chamber 3 in order to prevent overpressures in the user's nostril when the nasal guide is inserted tightly therein.
  • auxiliary cover shown by 30, adapted to be fitted on the cup formation 11 and on the duct 4 as a replacement for the cover 14 in order to close it until the bulb 2 needs to be used.
  • cover 30 is provided with a blind tubular section 31 which, by engaging the recess 10 of the duct 4, closes the chamber 3 in a leak-tight manner. In this way, the device 1 may be pre-packaged with appropriate doses of treatment fluid and sold in this way.
  • the variant IOOA differs from the first embodiment solely in that the tubular member 115 used in the formation of the nozzle 21 and its supply riser is formed separately from the cover 14 and is fitted on the duct 4 and kept spaced therefrom in order to form the space 16 by means of raised portions, spacers or ribs (not shown).
  • the variant IOOB is identical to the preceding variant except that the cover is not provided with a tubular sleeve adapted to act as a nasal supply guide.
  • the variant 200 differs from the first embodiment in that the cover 214 and the auxiliary cover 230 are snap on the cup formation 211 to close the chamber 3 by using a collar 201 provided with an annular recess 202 in a corresponding seat 203 provided with a corresponding annular relief 204.
  • the variant 300 differs from the embodiment 200 in that the nozzle
  • tubular sleeve 301 provided with radial apertures 302 adapted to balance the pressure to which the user's nostril is subject and the pressure in the chamber 3 in order to prevent undesirable overpressures.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif (1) pour administrer des fluides sous forme nébulisée. Ce dispositif comprend un élément formant ampoule (2) dans lequel un compartiment de recueillement (3) destiné au fluide à nébuliser est formé, et un conduit (4), une extrémité (5) pouvant être reliée à une source d'alimentation de gaz comprimé, s'étendant à travers l'élément formant ampoule (2) et portant, à son extrémité opposée, un ajutage de nébulisation alimenté par un tuyau ascendant (18) s'étendant dans le compartiment susmentionné. Le conduit s'étend sous le compartiment, l'ajutage étant disposé à une extrémité distale de celui-ci par rapport à la chambre.
PCT/IT2006/000523 2005-07-21 2006-07-10 Dispositif pour administrer des fluides sous forme nebulisee Ceased WO2007010579A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06766381A EP1909967A1 (fr) 2005-07-21 2006-07-10 Dispositif pour administrer des fluides sous forme nebulisee

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBS20050089 ITBS20050089A1 (it) 2005-07-21 2005-07-21 Dispositivo per la somministrazione di liquidi in forma nebulizzata
ITBS2005A000089 2005-07-21

Publications (1)

Publication Number Publication Date
WO2007010579A1 true WO2007010579A1 (fr) 2007-01-25

Family

ID=37400860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2006/000523 Ceased WO2007010579A1 (fr) 2005-07-21 2006-07-10 Dispositif pour administrer des fluides sous forme nebulisee

Country Status (3)

Country Link
EP (1) EP1909967A1 (fr)
IT (1) ITBS20050089A1 (fr)
WO (1) WO2007010579A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2732881A1 (fr) * 2012-11-14 2014-05-21 Air Liquide Medical Systems S.p.A. Micro-nébuliseur pour le nettoyage ou le traitement du nez

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE399348A (fr) * 1932-12-13 1933-11-30 Charles Baldwin Millett Perfectionnements aux vaporisateurs et aux atomiseurs
FR1461679A (fr) * 1965-10-29 1966-02-25 Buse pour appareil de pulvérisation, en particulier pour la production d'aérosols
EP0732111A2 (fr) * 1995-03-14 1996-09-18 MEFAR S.p.A. Dispositif de douche micronisé pour le nettoyage du nez et des cavités voisines
USRE36070E (en) * 1993-11-09 1999-02-02 Mefar S.P.A. Micronized spray device
US5906198A (en) * 1996-07-16 1999-05-25 Flickinger; William J. Nasal nebulizer
EP1044699A1 (fr) * 1997-10-17 2000-10-18 MEFAR S.p.A. Apppareil pour nettoyer les cavités nasales
WO2003035270A1 (fr) * 2001-10-25 2003-05-01 Valois Sas Embout otologique et dispositif de distribution de produit fluide comportant un tel embout

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE399348A (fr) * 1932-12-13 1933-11-30 Charles Baldwin Millett Perfectionnements aux vaporisateurs et aux atomiseurs
FR1461679A (fr) * 1965-10-29 1966-02-25 Buse pour appareil de pulvérisation, en particulier pour la production d'aérosols
USRE36070E (en) * 1993-11-09 1999-02-02 Mefar S.P.A. Micronized spray device
EP0732111A2 (fr) * 1995-03-14 1996-09-18 MEFAR S.p.A. Dispositif de douche micronisé pour le nettoyage du nez et des cavités voisines
US5906198A (en) * 1996-07-16 1999-05-25 Flickinger; William J. Nasal nebulizer
EP1044699A1 (fr) * 1997-10-17 2000-10-18 MEFAR S.p.A. Apppareil pour nettoyer les cavités nasales
WO2003035270A1 (fr) * 2001-10-25 2003-05-01 Valois Sas Embout otologique et dispositif de distribution de produit fluide comportant un tel embout

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2732881A1 (fr) * 2012-11-14 2014-05-21 Air Liquide Medical Systems S.p.A. Micro-nébuliseur pour le nettoyage ou le traitement du nez

Also Published As

Publication number Publication date
ITBS20050089A1 (it) 2007-01-22
EP1909967A1 (fr) 2008-04-16

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