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WO2007010240A3 - Method for high-throughput screening - Google Patents

Method for high-throughput screening Download PDF

Info

Publication number
WO2007010240A3
WO2007010240A3 PCT/GB2006/002664 GB2006002664W WO2007010240A3 WO 2007010240 A3 WO2007010240 A3 WO 2007010240A3 GB 2006002664 W GB2006002664 W GB 2006002664W WO 2007010240 A3 WO2007010240 A3 WO 2007010240A3
Authority
WO
WIPO (PCT)
Prior art keywords
platelets
platelet
activation
screen
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/002664
Other languages
French (fr)
Other versions
WO2007010240A2 (en
Inventor
Hans Deckmyn
Isabelle Salles
Alexandre Fontayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION
EUROP CARDIOVASCULAR GENETICS
Original Assignee
EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION
EUROP CARDIOVASCULAR GENETICS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION, EUROP CARDIOVASCULAR GENETICS filed Critical EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION
Publication of WO2007010240A2 publication Critical patent/WO2007010240A2/en
Publication of WO2007010240A3 publication Critical patent/WO2007010240A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/7056—Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
    • G01N2333/70564—Selectins, e.g. CD62
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/222—Platelet disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to methods for assessing platelet activation. Such methods can be used to diagnose whether a subject has an increased risk of bleeding or thrombosis, to screen for compounds that are agonists or antagonists of platelet activation, or to screen for defective platelets. The invention provides a method for assessing platelet activation, which comprises: stimulating platelets in a platelet sample to cause activation of the platelets; capturing activated platelets from the platelet sample in preference to resting platelets; and detecting the captured activated platelets.
PCT/GB2006/002664 2005-07-18 2006-07-18 Method for high-throughput screening Ceased WO2007010240A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0514678A GB0514678D0 (en) 2005-07-18 2005-07-18 Method for high-throughput screening
GB0514678.2 2005-07-18

Publications (2)

Publication Number Publication Date
WO2007010240A2 WO2007010240A2 (en) 2007-01-25
WO2007010240A3 true WO2007010240A3 (en) 2007-05-03

Family

ID=34897368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002664 Ceased WO2007010240A2 (en) 2005-07-18 2006-07-18 Method for high-throughput screening

Country Status (2)

Country Link
GB (1) GB0514678D0 (en)
WO (1) WO2007010240A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790410B2 (en) 2008-04-25 2010-09-07 General Electric Company Method and apparatus for determining hemocompatibility
CN103728450B (en) * 2013-11-08 2015-12-30 洛阳莱普生信息科技有限公司 A kind of detection clenobuterol hydrochloride chemiluminescence detection kit
CN103675273B (en) * 2013-11-12 2015-12-09 洛阳莱普生信息科技有限公司 A kind of CDV antigen chemiluminescence detection kit
CN103645320B (en) * 2013-11-19 2015-12-02 洛阳莱普生信息科技有限公司 A kind of AMOZ chemiluminescent enzyme-linked immunosorbent immunity quick detection kit
CN103675287B (en) * 2013-12-12 2015-11-25 洛阳莱普生信息科技有限公司 A kind of ivermectin chemiluminescent enzyme-linked immunosorbent immunity quick detection kit
CN103645322B (en) * 2013-12-12 2015-12-30 洛阳莱普生信息科技有限公司 A kind of chemical luminescence ELISA detection kit of streptomysin
CN103675286B (en) * 2013-12-12 2015-11-25 洛阳莱普生信息科技有限公司 A kind of lincomycin chemiluminescent enzyme-linked immunosorbent immunity quick detection kit
FR3109999B1 (en) * 2020-05-05 2024-06-14 Francais Du Sang Ets METHOD FOR DETECTING PLATELET ACTIVATION LINKED TO INFLAMMATION
CN115737814B (en) * 2022-10-26 2024-06-21 中国科学院大学 Antiplatelet drug and preparation method, antiplatelet drug capture agent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013307A1 (en) * 1992-12-11 1994-06-23 Steritech, Inc. Platelet activation and function
WO2000043793A1 (en) * 1999-01-26 2000-07-27 Du Pont Pharmaceuticals Company A FACS METHOD FOR DETECTION OF GPIIb/IIIa INHIBITOR DEPENDENT ACTIVATORS IN PLASMA SAMPLES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013307A1 (en) * 1992-12-11 1994-06-23 Steritech, Inc. Platelet activation and function
WO2000043793A1 (en) * 1999-01-26 2000-07-27 Du Pont Pharmaceuticals Company A FACS METHOD FOR DETECTION OF GPIIb/IIIa INHIBITOR DEPENDENT ACTIVATORS IN PLASMA SAMPLES

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAZUOKI OSUMI ET AL: "Development and Assessment of Enzyme Immunoassay for Platelet-derived Microparticles", THROMBOSIS AND HAEMOSTASIS, STUTTGART, DE, vol. 85, 2001, pages 326 - 330, XP002979230, ISSN: 0340-6245 *

Also Published As

Publication number Publication date
GB0514678D0 (en) 2005-08-24
WO2007010240A2 (en) 2007-01-25

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