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WO2007009710A3 - Substituted pyrazoline compounds: methods for their preparation - Google Patents

Substituted pyrazoline compounds: methods for their preparation Download PDF

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Publication number
WO2007009710A3
WO2007009710A3 PCT/EP2006/006984 EP2006006984W WO2007009710A3 WO 2007009710 A3 WO2007009710 A3 WO 2007009710A3 EP 2006006984 W EP2006006984 W EP 2006006984W WO 2007009710 A3 WO2007009710 A3 WO 2007009710A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
methods
pyrazoline compounds
preparation
substituted pyrazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/006984
Other languages
French (fr)
Other versions
WO2007009710A2 (en
Inventor
Jover Antonio Torrens
Minguez Susana Yenes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05384007A external-priority patent/EP1760078A1/en
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of WO2007009710A2 publication Critical patent/WO2007009710A2/en
Publication of WO2007009710A3 publication Critical patent/WO2007009710A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Methods for obtaining the substituted pyrazoline compounds of general formula (Ia) as well as the intermediates of general formula (III) to this compound. Thus 5-(R10,R11,R12-phenyl)-1-(R13,R14,R15-phenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H- pyrazole-3-carboxamide (II) can be obtained by the reaction of an activated carbonyl compound derived from 5-(R10,R11,R12-phenyl)-1-(R13,R14,R15-phenyl)-4,5-dihydro- 1H-pyrazole-3-carboxylic acid (IIIa) with N-aminopiperidine in the presence or absence of an acid acceptor or suitable condensing agent.
PCT/EP2006/006984 2005-07-15 2006-07-16 Substituted pyrazoline compounds: methods for their preparation Ceased WO2007009710A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05384007.0 2005-07-15
EP05384007A EP1760078A1 (en) 2005-07-15 2005-07-15 Substituted pyrazoline compounds; methods for their preparation
US70547405P 2005-08-05 2005-08-05
US60/705,474 2005-08-05

Publications (2)

Publication Number Publication Date
WO2007009710A2 WO2007009710A2 (en) 2007-01-25
WO2007009710A3 true WO2007009710A3 (en) 2007-04-19

Family

ID=37038368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/006984 Ceased WO2007009710A2 (en) 2005-07-15 2006-07-16 Substituted pyrazoline compounds: methods for their preparation

Country Status (1)

Country Link
WO (1) WO2007009710A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947090A1 (en) * 2007-01-17 2008-07-23 Laboratorios del Dr. Esteve S.A. Method for preparing N-piperidino-1,5-diphenylpyrazole-3-carboxamide and derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005046A2 (en) * 1987-01-05 1988-07-14 E.I. Du Pont De Nemours And Company Insecticidal pyrazolines
EP1083171A1 (en) * 1998-05-29 2001-03-14 Laboratorios Del Dr. Esteve, S.A. Pyrazoline derivatives, their preparation and application as medicaments
EP1233944A2 (en) * 1999-11-21 2002-08-28 Morphochem AG Coupling condensation synthesis of heterocycles
WO2005077911A1 (en) * 2004-02-17 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005046A2 (en) * 1987-01-05 1988-07-14 E.I. Du Pont De Nemours And Company Insecticidal pyrazolines
EP1083171A1 (en) * 1998-05-29 2001-03-14 Laboratorios Del Dr. Esteve, S.A. Pyrazoline derivatives, their preparation and application as medicaments
EP1233944A2 (en) * 1999-11-21 2002-08-28 Morphochem AG Coupling condensation synthesis of heterocycles
WO2005077911A1 (en) * 2004-02-17 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BEN H. NICOLET: "The Addition of Mercaptans to Certain Double Bonds", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 57, 1935, pages 1098 - 1099, XP002358249 *
EMMA DIETZ STECHER, ANITA WALDMANN, DIANE FABINY: "Benzylidenepyruvic Avids. V. m-Nitrobenzylidenepyruvic Acid and its Enol-Lactone Tautomer", JOURNAL OF ORGANIC CHEMISTRY, vol. 30, 1965, pages 1800 - 1805, XP002358248 *
FEID-ALLAH H M: "TRISUBSTITUTED PYRAZOLES OF POSSIBLE ANTIDIABETIC AND ANTIBACTERIAL ACTIVITY TRISUBSTITUIERTE PYRAZOLE MIT POTENTIELLER ANTIDIABETISCHER UND ANTIBAKTERIELLER WIRKUNG", PHARMAZIE, DIE, GOVI VERLAG, ESCHBORN, DE, vol. 36, no. 11, 1981, pages 754 - 756, XP009000312, ISSN: 0031-7144 *
KOICHI TANAKA, RYUSUKE SHIRAISHI, FUMIO TODA: "A new method for the stereoselective bromination of stilbene and chalcone in a water suspension medium", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS I, 1999, pages 3069 - 3070, XP002358531 *
LOUIS H. P. MEIJER, UPENDRA K. PANDIT: "Chemoselective Metal Ion Catalyzed Reduction of alpha-Keto-beta,gamma-unsaturated Esters by 1,4-Dihydropyridine Derivatives", TETRAHEDRON, vol. 41, no. 2, 1985, pages 467 - 472, XP002358251 *
M. G. JOSHI, K. N. WADODKAR: "Action of Phenylhydrazine Hydrochloride on Chalkone Dibromides in Dimethylformamide", INDIAN JOURNAL OF CHEMISTRY, vol. 20B, 1981, pages 1090 - 1092, XP009058438 *
MARIE REIMER, ANNE L. MORRISON: "Addition Reactions of alpha-Ketonic Acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 63, 1941, pages 236 - 240, XP002358250 *
RAAFAT SOLIMAN, HASSAN M. FEID-ALLAH, SAMIR K. EL SADANY, HOSNY F. MOHAMED: "Preparation and Antidiabetic Activity of New substituted 3,5-Diarylpyrazolesulfonylurea Derivatives", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 70, no. 6, 1981, pages 606 - 610, XP009058748 *
THOMAS J. J. MÜLLER, MARKUS ANSORGE, DANIEL AKTAH: "An Unexpected Coupling-Isomerization Sequence as an Entry to Novel Three-Component-Pyrazoline Syntheses", ANGEWANDTE CHEMIE, vol. 39, no. 7, 2000, pages 1253 - 1256, XP002358515 *
WEI SHENG HUANG, CHENG YE YUAN: "A new and convenient one-pot synthesis of alpha,beta-unsaturated trifluoromethyl ketones", JOURNAL OF THE CHEMICAL SOCIETY PERKIN TRANSACTIONS 1, vol. 7, 1995, pages 741 - 742, XP009058449 *
ZIELINSKA-BLAJET M ET AL: "Ring-closure reactions through intramolecular substitution of thiophenoxide by oxygen and nitrogen nucleophiles: simple stereospecific synthesis of 4,5-dihydroisoxazoles and 4,5-dihydropyrazoles", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 22, 30 May 2005 (2005-05-30), pages 5235 - 5240, XP004881934, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
WO2007009710A2 (en) 2007-01-25

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