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WO2007005249A3 - Nanoparticles and dendritic-polymer-based hydrogels comprising them - Google Patents

Nanoparticles and dendritic-polymer-based hydrogels comprising them Download PDF

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Publication number
WO2007005249A3
WO2007005249A3 PCT/US2006/023723 US2006023723W WO2007005249A3 WO 2007005249 A3 WO2007005249 A3 WO 2007005249A3 US 2006023723 W US2006023723 W US 2006023723W WO 2007005249 A3 WO2007005249 A3 WO 2007005249A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
lens
relates
another aspect
ceramic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/023723
Other languages
French (fr)
Other versions
WO2007005249A2 (en
Inventor
Michael A Carnahan
Jeffrey A Clark
Mark W Grinstaff
Kenneth E Stockman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperbranch Medical Technology Inc
Original Assignee
Hyperbranch Medical Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology Inc filed Critical Hyperbranch Medical Technology Inc
Publication of WO2007005249A2 publication Critical patent/WO2007005249A2/en
Anticipated expiration legal-status Critical
Publication of WO2007005249A3 publication Critical patent/WO2007005249A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

One aspect of the present invention relates to compositions comprising polymers and nanoparticles that form hydrogels useful as lens replacement materials, lens substitute materials, corneal inlays, and intraocular lenses. The hydrogels of the invention can be formed using a polyacrylate, silicone, or dendritic macromolecule. In certain instances, the hydrogels of the invention comprise nanoparticles ranging in diameter from about 0.1 nm to about 100 nm. The nanoparticles are generally dispersed throughout the hydrogel and may be covalently or noncovalently crosslinked. The nanoparticles may be made of a metal, metal oxide, or ceramic. In certain instances, the nanoparticles comprise a ceramic core coated with a layer of silica. Another aspect of the present invention relates to a method of forming a lens composition comprising treating a mixture of a polymerizable dendrimeric compound and nanoparticles with a polymerization agent. Another aspect of the present invention relates to a nanoparticle comprising a core coated with a layer of silica. In certain instances, the core is made of a metal, metal oxide, or ceramic. Another aspect of the invention relates to a kit for forming a lens comprising a polymerizable dendrimeric compound, nanoparticles, and a system for delivering the dendrimeric compound and nanoparticles to the lens bag of a patient.
PCT/US2006/023723 2005-06-29 2006-06-19 Nanoparticles and dendritic-polymer-based hydrogels comprising them Ceased WO2007005249A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69494405P 2005-06-29 2005-06-29
US60/694,944 2005-06-29

Publications (2)

Publication Number Publication Date
WO2007005249A2 WO2007005249A2 (en) 2007-01-11
WO2007005249A3 true WO2007005249A3 (en) 2009-04-16

Family

ID=37604937

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/023723 Ceased WO2007005249A2 (en) 2005-06-29 2006-06-19 Nanoparticles and dendritic-polymer-based hydrogels comprising them

Country Status (1)

Country Link
WO (1) WO2007005249A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
CN109912816B (en) * 2019-03-05 2021-05-28 中原工学院 A kind of preparation method of polypyrrole/polyurethane composite conductive hydrogel

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1996243B1 (en) 2006-01-11 2014-04-23 HyperBranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
EP2502628B1 (en) 2006-06-23 2016-12-14 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
US8262608B2 (en) 2007-01-25 2012-09-11 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP2362908A4 (en) 2008-11-03 2013-09-18 Alethia Biotherapeutics Inc ANTIBODIES FOR THE SPECIFIC BLOCKING OF THE BIOLOGICAL ACTIVITY OF A TUMORANT
EP2396070B1 (en) 2009-02-12 2024-12-04 Incept Llc Drug delivery through hydrogel plugs
US20100249273A1 (en) * 2009-03-31 2010-09-30 Scales Charles W Polymeric articles comprising oxygen permeability enhancing particles
CA2760704C (en) 2009-05-04 2017-10-03 Incept, Llc Biomaterials for track and puncture closure
CN102844054B (en) 2009-12-15 2016-04-20 因赛普特有限责任公司 Implant and the biodegradable fiducial marker of energy
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP3173427B1 (en) 2011-03-31 2019-06-19 ADC Therapeutics SA Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US20170174753A1 (en) 2012-01-09 2017-06-22 Alethia Biotherapeutics Inc. Method for treating breast cancer
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
US20160166504A1 (en) 2014-12-10 2016-06-16 Incept, Llc Hydrogel drug delivery implants
JP2018515529A (en) 2015-05-12 2018-06-14 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ Drug delivery from hydrogels
CN108601725B (en) 2015-11-25 2024-03-08 因赛普特有限责任公司 Shape-changing drug delivery device and method
US12171869B2 (en) 2016-09-23 2024-12-24 Incept, Llc Intracameral drug delivery depots
KR20220148869A (en) * 2020-03-04 2022-11-07 다나-파버 캔서 인스티튜트 인크. Structurally stabilized antiviral SARS-CoV-2 peptides and uses thereof
BR112023018676A2 (en) 2021-03-18 2023-10-10 Seagen Inc ANTIBODY-DRUG CONJUGATE, PHARMACEUTICAL COMPOSITION, METHODS OF TREATMENT OF A DISEASE OR CONDITION AND A CANCER, AND, LINDER-DRUG CONJUGATE COMPOSITION
CN114321939B (en) * 2021-12-27 2023-04-14 北京北控绿海能环保有限公司 Waste incineration treatment process
CN115322628B (en) * 2022-06-30 2023-04-11 安徽登王化工有限公司 High-wear-resistance fluorocarbon powder coating and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086479A1 (en) * 2001-02-26 2004-05-06 Duke University Novel dendritic polymers, crosslinked gels, and their biomedical uses
US20040096477A1 (en) * 2002-06-05 2004-05-20 Anuj Chauhan Ophthalmic drug delivery system
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US20040155312A1 (en) * 2001-06-20 2004-08-12 Wolfgang Muller-Lierheim Optical element, especially an eye implant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086479A1 (en) * 2001-02-26 2004-05-06 Duke University Novel dendritic polymers, crosslinked gels, and their biomedical uses
US20040155312A1 (en) * 2001-06-20 2004-08-12 Wolfgang Muller-Lierheim Optical element, especially an eye implant
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US20040096477A1 (en) * 2002-06-05 2004-05-20 Anuj Chauhan Ophthalmic drug delivery system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
CN109912816B (en) * 2019-03-05 2021-05-28 中原工学院 A kind of preparation method of polypyrrole/polyurethane composite conductive hydrogel

Also Published As

Publication number Publication date
WO2007005249A2 (en) 2007-01-11

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