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WO2007004300A1 - Produit cosmétique - Google Patents

Produit cosmétique Download PDF

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Publication number
WO2007004300A1
WO2007004300A1 PCT/JP2005/012479 JP2005012479W WO2007004300A1 WO 2007004300 A1 WO2007004300 A1 WO 2007004300A1 JP 2005012479 W JP2005012479 W JP 2005012479W WO 2007004300 A1 WO2007004300 A1 WO 2007004300A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
collagen
ceramide
hyaluronic acid
cosmetic product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/012479
Other languages
English (en)
Japanese (ja)
Inventor
Yoshinori Shirono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drci labo Co Ltd
Original Assignee
Drci labo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drci labo Co Ltd filed Critical Drci labo Co Ltd
Priority to JP2007523317A priority Critical patent/JPWO2007004300A1/ja
Priority to PCT/JP2005/012479 priority patent/WO2007004300A1/fr
Publication of WO2007004300A1 publication Critical patent/WO2007004300A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the present invention relates to a cosmetic product having an excellent moisturizing effect and capable of improving the moisture and tension of the skin.
  • the conventional gel-like basic cosmetics as described above are used to improve skin tension and moisture. Is also effective.
  • the present invention has been proposed to meet the above-described demand, and an object of the present invention is to provide a cosmetic product that can improve skin tension and moisture by being applied to the skin.
  • the cosmetic product of the present invention comprises a minute container (nanocapsule: trade name Nanosphere) made of hyaluronic acid, and contains the collagen and ceramide in the minute container, and the minute container containing the collagen and ceramide. Is contained in a gel-like basic cosmetic product in an amount of 0.1 to 5% by weight. It is characterized by.
  • the gel-like basic cosmetic product preferably contains ceramide, collagen, and hyaluronic acid.
  • the gel-like basic cosmetics contain vitamin C, laminaria taroroika extract (amber ocean), and pervetianacanalicurata extract.
  • the content of vitamin C is kept to a relatively small amount, and the content of laminaria taroroika extract (amber ocean) and Z or pervetia canariculata extract is 5% by weight or less.
  • a minute container (power capsule: nanocapsule) is composed of hyaluronic acid, and collagen and ceramide are incorporated in the minute container.
  • the inner capsule penetrates to the inner layer (for example, the dermis layer) of the skin surface (stratum corneum or epidermis layer).
  • a minute container (capsule) is formed! /
  • the peptide structure of hyaluronic acid is used as an enzyme in the body. More decomposed, decomposed hyaluronic acid, collagen and ceramide diffuse in the inner layer of the epidermis (for example, dermis layer) and exert an effect of moisturizing and moisturizing from the inside of skin (moisturizing effect or moisture effect) To do.
  • the gel-like basic cosmetic is composed of ceramide, collagen, hyaluronic acid, vitamin C, laminaria taroroleuca extract, pervetia canariculata extract, and ceramide, collagen, hyaluron If the blending ratio of the acid is made much higher than that of the conventional basic cosmetic (gel), the moisturizing property of the gel-type basic cosmetic itself is much higher than that of the conventional product.
  • a minute container or a capsule permeates the skin, and exerts an inner force moisture effect on the skin.
  • ceramide, collagen, and hyaluronic acid contained in gel-like basic cosmetics exert a moisturizing effect from the outside (skin side) of the skin.
  • the inside of the skin nanocapsules and their built-in components
  • the outside of the skin depending on the ingredients blended in the gel
  • it can exert an effect of moisturizing and moisturizing the skin (moisturizing effect or moisture effect).
  • moisturizing effect or moisture effect the so-called “double moisture effect” can be exhibited.
  • the cosmetic of the present invention can naturally moisturize from the inside of the skin.
  • the present invention is very effective for the purpose of imparting tension and moisture to “dry skin”.
  • the gel-like basic cosmetic contains vitamin C, laminaria taroloika kiss (amber ocean), and pervetia canarikurata extract, these components are all Because of its so-called “whitening” effect, it has the effect of beautifying the skin.
  • Laminaria taroroika extract has the effect of rejuvenating the skin
  • Pervetianakana lyclata extract has the effect of activating fibroblasts.
  • 1 to 6 show one embodiment of the present invention functionally and schematically.
  • reference numeral 10 denotes a small container or capsule (a “nano” level size capsule: for example, a product manufactured and sold by Corety Power Company under the trade name “Nanosphere”).
  • the fine capsule 10 is composed of hyaluronic acid.
  • the minute capsule has a spherical shape, and its diameter is 300 ⁇ ! ⁇ 700nm.
  • the microcapsule 10 includes collagen 12 and ceramide 14.
  • collagen 12 and ceramide 14 are represented as a single sphere, but such representation is simplified for ease of understanding. A possible amount of collagen 12 and ceramide 14 is incorporated.
  • Hyaluronic acid microcapsules 10 incorporating collagen 12 and ceramide 14 are added to gel-like basic cosmetic product 20 (arrow D) and mixed uniformly as shown in FIG.
  • a conventionally known mixing technique can be applied to the mixing method.
  • the gel-like basic cosmetic 20 is also blended with collagen 22, ceramide 24, hyaluronic acid 26 power S, and it is blended with the gel-like basic cosmetic 20 (in other words, it is not a microcapsule).
  • the forms of collagen 22, ceramide 24, and hyaluronic acid 26 are shown in Figure 2 with the same crossed star!
  • the cosmetic 30 of the present invention is completed by mixing the microcapsules 10 into the gel-like basic cosmetic 20 (FIG. 3).
  • the cosmetic product 30 of the present invention is configured in a gel form, and as shown in FIG. 3, the microcapsules 10 made of hyaluronic acid containing collagen 12 and ceramide 14 (shown by small circles in FIGS. 3 and 4). ) And collagen 22, ceramide 24, and hyaluronic acid 26 (shown as crosses in FIGS. 3 and 4) that were previously included in the gel-like basic cosmetic 20 separately from the microcapsule 10. ing.
  • FIG. 4 is a partial cross-sectional view showing a state in which the cosmetic 30 according to the embodiment is applied to the skin.
  • the skin to which cosmetic 30 is applied is composed of stratum corneum A, epidermis layer B, and dermis layer C.
  • the dermis layer C shows only a part thereof.
  • the cosmetic 30 is pre-mixed with the gel basic cosmetic 20.
  • Collagen 22, ceramide 24, and hyaluronic acid 26 (cross star) (not microcapsules) remain on the surface of stratum corneum A (upper in Fig. 4).
  • microcapsules 10 (white small circles) permeate stratum corneum A and epidermis layer B and penetrate to dermis layer C.
  • the size (or particle size) of ⁇ 700 nm is selected as a size that can reach the dermis layer C through the stratum corneum A and the epidermis layer B.
  • the hyaluronic acid microcapsules 10 that have reached the dermis layer C have the peptide structure of hyaluronic acid shredded by the enzyme 40 present in the dermis layer, and the molecular weight is reduced. This is a relatively small state (indicated by reference numeral 10P).
  • the hyaluronic acid constituting the microcapsule 10 is shredded, so that the collagen 12 and the ceramide 14 incorporated in the capsule 10 jump out of the capsule 10 (see arrow E) and diffuse in the dermis layer C.
  • hyaluronic acid having a peptide structure is subdivided to such an extent that it can be incorporated in a nanocapsule, the effect of improving "moisture moisture” and “skin elasticity” can no longer be exhibited. . Therefore, microcapsules were produced with hyaluronic acid.
  • the molecular weight is smaller than in the nanocapsule state! /, But this improves the “moisturizing!” And “skin elasticity”. ! The molecular weight is large enough to exert the effect (the state indicated by 10P in FIGS. 5 and 6). In other words, if hyaluronic acid is not made into a microcapsule, the expected action (moisturation of skin, skin firmness) will not be achieved, and hyaluronic acid is expected for the first time by subdividing the microcapsule with an enzyme. To exert the effect.
  • Hyaluronic acid 10P, collagen 12, and ceramide 14 moisturize the skin from the inner side of the skin (the dermis layer C side).
  • the cosmetic 30 As described above, in the skin to which the cosmetic 30 according to the illustrated embodiment is applied, it is preliminarily blended in the gel-like basic cosmetic 20 from the surface side of the skin (the stratum corneum A side).
  • Collagen 22, Ceramide 24, Hyaluronic Acid 26 (Cross Stars) provides a moisturizing and skin-strengthening effect (moisture effect), and the inner side of the skin (the dermis layer C side) has very little force
  • the hyaluronic acid 10P that constitutes the capsule and the collagen 12 and ceramide 14 incorporated in the microcapsule exert an effect of moisturizing and stretching the skin (moisture effect).
  • the skin is moisturized and stretched both from the surface side of the skin (the stratum corneum A side) and from the inside of the skin (the dermal layer C side).
  • the effect that brings about is demonstrated.
  • the cosmetic product 30 according to the illustrated embodiment has a much more moisturizing effect than a conventional cosmetic product (for example, a cosmetic product manufactured and sold by the applicant under the trade name "Sealab Aqua Collagen Gel”). Became a good cosmetic. In other words, the skin is much moisturized compared to conventional cosmetics.
  • a conventional cosmetic product for example, a cosmetic product manufactured and sold by the applicant under the trade name "Sealab Aqua Collagen Gel”
  • a time difference can be generated between the timing at which the moisture effect is exhibited in the skin surface layer portion and the timing at which the moisture effect is exhibited inside the skin. As a whole, the time during which the moisture effect is exerted can be lengthened.
  • Spherical microcapsules with a diameter of 300nm to 700nm are manufactured with hyaluronic acid and contain collagen and ceramide inside.
  • the diameter of the microcapsule when the diameter of the microcapsule is too large, it cannot penetrate the stratum corneum and the epidermis layer and reach the dermis layer. On the other hand, when the diameter of the microcapsule is too large, it becomes difficult to form the capsule and to accommodate the collagen and ceramide inside the capsule.
  • the amount or ratio of collagen and ceramide is not particularly limited as long as both can be accommodated in a single microcapsule.
  • Hyaluronic acid microcapsules containing collagen and ceramide are mixed and mixed.
  • the gel-like basic cosmetic product is not particularly limited as long as it is a “basic cosmetic product” in the ordinary sense.
  • the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic is 0.1% to 5% by weight.
  • Hyaluronic acid-containing microcapsules containing collagen and ceramide contain too little weight (less than 0.1% by weight) and penetrate into the stratum corneum and epidermis layer, from the dermis layer (skin The effect of moisturizing and stretching the skin (from the inside of the skin) (moisture effect) is not fully demonstrated.
  • the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic was determined to be in the range of 0.1 to 5% by weight.
  • the accurate threshold value was set at 0.1% by weight at which the improvement of skin moisture and tension was actually confirmed as the lower limit of force that was considered to be 0.08% to 0.1% by weight.
  • the coating amount of the hyaluronic acid microcapsules containing collagen and ceramide is increased from 3.5% by weight to 6.5% by weight every 0.5% by weight, and applied to the skin. Was checked.
  • the applicability to the skin was determined by whether or not 70% of the subjects felt discomfort (foreign material sensation) when subjects applied to the skin. That is, when 70% or more of the subjects felt uncomfortable or foreign object feeling during application, it was determined that “I felt a foreign object feeling” (X in Table 2). If it was less than%, it was determined that there was no “foreign object sensation” (circles in Table 2).
  • the gel-like basic cosmetic contains hyaluronic acid that does not constitute a microcapsule, collagen and ceramide that are not contained in the microcapsule.
  • the content is about 1.2 to 1.8 times that of conventional cosmetics (for example, the cosmetic product “Sealab Aqua Collagen Gel” manufactured and sold by the applicant).
  • the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetic is low, the moisture effect from the front side (skin layer side) of the skin may not be sufficiently exhibited.
  • conventional cosmetics for example, the brand name “Shi Lab Aqua Aqua” manufactured and sold by the applicant.
  • the gel-like basic cosmetic product itself becomes hard and uncomfortable for the user when placed on the skin. End up.
  • the sticky feeling increases.
  • the amount of collagen and hyaluronic acid is large, the basic cosmetic product becomes hard, and the amount of oil, ceramide, increases and the feeling of stickiness increases.
  • the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetics is the same as that of conventional cosmetics (for example, the cosmetic product “Sealab Aquacollagen Gel” manufactured and sold by the applicant). ) Must be less than twice.
  • the collagen contained in the microcapsule is a collagen tripeptide having a molecular weight of about 280, and the collagen contained in the gel basic cosmetic product has a molecular weight of 5000.
  • Collagen tripeptides with a low molecular weight penetrate well into tissues inside the skin, whereas collagen with a high molecular weight (including microcollagen in addition to normal collagen) This is because the effect of covering and preventing drying is exhibited satisfactorily. That is, a collagen tripeptide having a small molecular weight (with a molecular weight of about 280) is incorporated in a microcapsule made of hyaluronic acid and is suitable for penetrating the inside of the skin. On the other hand, collagen having a large molecular weight (ordinary collagen and microcollagen) is suitable for being previously contained in a gel-like basic cosmetic product.
  • the gel-like basic cosmetic further contains vitamin C, laminaria taroloica extract (amber ocean), which is an extract from seaweed, and Pervetianacari crata extract, which is also a seaweed extract.
  • Vitamin C has a so-called “whitening” effect. However, since it oxidizes, the content must be kept to a very small amount.
  • Laminaria taro leuca extract Amber Ocean
  • Pervetiana canary crata extract which are seaweed extracts, are whitening ingredients comparable to bioantage.
  • the Laminaria taroroika extract is a seaweed extract, but has the same action as DHEA (Anchoring Ginsing Hormone), that is, the action of rejuvenating the skin.
  • Pervetianacaricrata extract has the effect of activating fibroblasts. The applicant applied a sample with a pervetia canarikurata extract content of 2% to 3% by weight, and the experiment showed that the activity of the fibroblasts increased from 0% to 115%. It has gained.
  • Laminaria taro leuca extract (Amber Ocean) and Pervetianacana crata extract are seaweed extracts, and if the content is too large, the entire cosmetic product becomes brown and gives off a strange odor.
  • Experiment 3 described below, when the total content of Laminaria taroroika extract (Amber Ocean) and Pervetianacana crutta echex exceeds 5% by weight, a bad odor is detected. I was able to do it.
  • Spherical microcapsules with a diameter of 300 nm to 700 nm are manufactured with hyaluronic acid, and collagen and ceramide are accommodated inside. Then, 3.0% by weight of capsules (microcapsules made of hyaluronic acid containing collagen and ceramide) is added to the gel-like basic cosmetics.
  • the hyaluronic acid that does not make up the product, collagen that is not contained in the microcapsules, and ceramide are 1.5 times the amount of conventional cosmetics (the cosmetics that are manufactured and sold by the applicant, the product name “Sealab Aqua Collagen Gel”). Contains the amount.
  • a cosmetic test having such a composition was compared with a conventional cosmetic product (a cosmetic product manufactured and sold by the applicant under the name “Sealab Aqua Collagen Gel”).
  • FIG. 1 is a schematic diagram of a microcapsule that is a main component of an embodiment of the present invention.
  • FIG. 2 is a schematic diagram of a process of mixing the microcapsules of FIG. 1 with basic cosmetics.
  • FIG. 3 is a schematic diagram of a cosmetic product according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram showing the action when the cosmetic of FIG. 3 is applied to the skin.
  • FIG. 5 is a schematic diagram showing the action when the microcapsules of FIG. 1 reach the dermis layer.
  • FIG. 6 is a schematic diagram showing the action of the cosmetic product according to the embodiment of the present invention.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention a pour objet un produit cosmétique qui peut améliorer la bonne condition de la peau et l'hydratation de la peau en l'appliquant sur la peau. Pour réaliser l'objet, le produit cosmétique de l'invention est caractérisé en ce qu'on forme un micro-récipient ou une microcapsule avec de l'acide hyaluronique, on encapsule du collagène et un céramide dans la microcapsule et on incorpore la microcapsule, dans laquelle sont encapsulés le collagène et le céramide, dans un produit cosmétique gélifié de base en quantité de 0,1 à 5 % en poids. Ici, le produit cosmétique gélifié de base contient de préférence un céramide, du collagène, de l'acide hyaluronique, de la vitamine C, de l'extrait de Laminaria ochroleuca et de l'extrait de Pelvetia canaliculata. Avec le produit cosmétique de l'invention, la microcapsule elle-même pénètre dans la peau et exerce un effet hydratant à partir de l'intérieur de la peau. D'un autre côté, le céramide, le collagène et l'acide hyaluronique contenus dans le produit cosmétique gélifié de base exercent un effet hydratant à partir de l'extérieur de la peau. A savoir que selon l'invention, un effet hydratant est exercé à partir de l'extérieur et à partir de l'intérieur de la peau.
PCT/JP2005/012479 2005-07-06 2005-07-06 Produit cosmétique Ceased WO2007004300A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007523317A JPWO2007004300A1 (ja) 2005-07-06 2005-07-06 化粧品
PCT/JP2005/012479 WO2007004300A1 (fr) 2005-07-06 2005-07-06 Produit cosmétique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2005/012479 WO2007004300A1 (fr) 2005-07-06 2005-07-06 Produit cosmétique

Publications (1)

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WO2007004300A1 true WO2007004300A1 (fr) 2007-01-11

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096140A2 (fr) 2003-04-25 2004-11-11 The Penn State Research Foundation Methode et systeme de liberation systemique de composes bioactifs derives de lipides, d'arret de croissance
JP2009161458A (ja) * 2007-12-28 2009-07-23 Rohto Pharmaceut Co Ltd 細胞のアスコルビン酸類の取り込み促進剤
WO2009136651A1 (fr) * 2008-05-09 2009-11-12 Fujifilm Corporation Composition topique pour une utilisation externe et son procédé de fabrication
EP2317981A4 (fr) * 2008-07-24 2012-08-08 Amorepacific Corp Granulé lamellaire multicouches et composition pour application externe sur la peau le contenant
JP2014051464A (ja) * 2012-09-07 2014-03-20 Panasonic Corp 生体活性分子封入粒子、生体活性用薬剤、生体活性分子封入粒子の生体内への浸透方法、並びに生体活性分子封入粒子放散装置及び空気清浄装置
JP2014129314A (ja) * 2012-12-30 2014-07-10 Shinshu Univ シート状パック基材、シート状パック及びシート状パック基材の製造方法
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
AU2013203710B2 (en) * 2007-11-30 2016-09-29 Allergan Industrie, Sas Polysaccharide gel formulation
US9737633B2 (en) 2011-06-03 2017-08-22 Allergan, Inc. Dermal filler compositions including antioxidants
US11083684B2 (en) 2011-06-03 2021-08-10 Allergan Industrie, Sas Dermal filler compositions
WO2023161415A1 (fr) * 2022-02-28 2023-08-31 Merck Patent Gmbh Utilisation cosmétique d'une composition comprenant un extrait d'algue aqueux de pelvetia canaliculata pour augmenter le brillant de la peau

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